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T cell immunity to glatiramer acetate ameliorates cognitive deficits induced by chronic cerebral hypoperfusion by modulating the microenvironment.

Vascular dementia (VaD) is a progressive and highly prevalent disorder. However, in a very large majority of cases, a milieu of cellular and molecular events common for multiple neurodegenerative diseases is involved. Our work focused on whether the immunomodulating effect of glatiramer acetate (GA)... Full description

Journal Title: Scientific reports September 22, 2015, Vol.5, p.14308
Main Author: Chen, Li
Other Authors: Yao, Yang , Wei, Changjuan , Sun, Yanan , Ma, Xiaofeng , Zhang, Rongxin , Xu, Xiaolin , Hao, Junwei
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 2045-2322 ; DOI: 10.1038/srep14308
Link: http://search.proquest.com/docview/1717482908/?pq-origsite=primo
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title: T cell immunity to glatiramer acetate ameliorates cognitive deficits induced by chronic cerebral hypoperfusion by modulating the microenvironment.
format: Article
creator:
  • Chen, Li
  • Yao, Yang
  • Wei, Changjuan
  • Sun, Yanan
  • Ma, Xiaofeng
  • Zhang, Rongxin
  • Xu, Xiaolin
  • Hao, Junwei
subjects:
  • Animals–Drug Effects
  • Behavior, Animal–Complications
  • Brain Ischemia–Immunology
  • Brain-Derived Neurotrophic Factor–Metabolism
  • Calcium-Binding Proteins–Pathology
  • Cognition Disorders–Metabolism
  • Cytokines–Genetics
  • Dementia, Vascular–Metabolism
  • Disease Models, Animal–Etiology
  • Glatiramer Acetate–Metabolism
  • Glial Fibrillary Acidic Protein–Metabolism
  • Hippocampus–Etiology
  • Long-Term Potentiation–Immunology
  • Male–Pharmacology
  • Maze Learning–Genetics
  • Microfilament Proteins–Metabolism
  • Rats–Metabolism
  • T-Lymphocytes–Drug Effects
  • T-Lymphocytes–Drug Effects
  • T-Lymphocytes
ispartof: Scientific reports, September 22, 2015, Vol.5, p.14308
description: Vascular dementia (VaD) is a progressive and highly prevalent disorder. However, in a very large majority of cases, a milieu of cellular and molecular events common for multiple neurodegenerative diseases is involved. Our work focused on whether the immunomodulating effect of glatiramer acetate (GA) could restore normalcy to the microenvironment and ameliorate cognitive decline induced by chronic cerebral hypoperfusion. We assessed cognitive function by rats' performance in a Morris water maze (MWM), electrophysiological recordings and by pathologic changes. The results suggest that GA reduced cognitive deficits by reestablishing an optimal microenvironment such as increasing expression of the brain-derived neurotrophic factor (BDNF) and modulating the Th1/Th2 cytokine balance in the hippocampus. When microenvironmental homeostasis is restored, cholinergic activity becomes involved in ameliorating cellular damage. Since vaccination with GA can boost "protective autoimmunity" in this way, a similar strategy may have therapeutic potential for alleviating VaD disease.
language: eng
source:
identifier: E-ISSN: 2045-2322 ; DOI: 10.1038/srep14308
fulltext: fulltext
issn:
  • 20452322
  • 2045-2322
url: Link


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titleT cell immunity to glatiramer acetate ameliorates cognitive deficits induced by chronic cerebral hypoperfusion by modulating the microenvironment.
creatorChen, Li ; Yao, Yang ; Wei, Changjuan ; Sun, Yanan ; Ma, Xiaofeng ; Zhang, Rongxin ; Xu, Xiaolin ; Hao, Junwei
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ispartofScientific reports, September 22, 2015, Vol.5, p.14308
identifierE-ISSN: 2045-2322 ; DOI: 10.1038/srep14308
subjectAnimals–Drug Effects ; Behavior, Animal–Complications ; Brain Ischemia–Immunology ; Brain-Derived Neurotrophic Factor–Metabolism ; Calcium-Binding Proteins–Pathology ; Cognition Disorders–Metabolism ; Cytokines–Genetics ; Dementia, Vascular–Metabolism ; Disease Models, Animal–Etiology ; Glatiramer Acetate–Metabolism ; Glial Fibrillary Acidic Protein–Metabolism ; Hippocampus–Etiology ; Long-Term Potentiation–Immunology ; Male–Pharmacology ; Maze Learning–Genetics ; Microfilament Proteins–Metabolism ; Rats–Metabolism ; T-Lymphocytes–Drug Effects ; T-Lymphocytes–Drug Effects ; T-Lymphocytes
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descriptionVascular dementia (VaD) is a progressive and highly prevalent disorder. However, in a very large majority of cases, a milieu of cellular and molecular events common for multiple neurodegenerative diseases is involved. Our work focused on whether the immunomodulating effect of glatiramer acetate (GA) could restore normalcy to the microenvironment and ameliorate cognitive decline induced by chronic cerebral hypoperfusion. We assessed cognitive function by rats' performance in a Morris water maze (MWM), electrophysiological recordings and by pathologic changes. The results suggest that GA reduced cognitive deficits by reestablishing an optimal microenvironment such as increasing expression of the brain-derived neurotrophic factor (BDNF) and modulating the Th1/Th2 cytokine balance in the hippocampus. When microenvironmental homeostasis is restored, cholinergic activity becomes involved in ameliorating cellular damage. Since vaccination with GA can boost "protective autoimmunity" in this way, a similar strategy may have therapeutic potential for alleviating VaD disease.
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titleT cell immunity to glatiramer acetate ameliorates cognitive deficits induced by chronic cerebral hypoperfusion by modulating the microenvironment.
authorChen, Li ; Yao, Yang ; Wei, Changjuan ; Sun, Yanan ; Ma, Xiaofeng ; Zhang, Rongxin ; Xu, Xiaolin ; Hao, Junwei
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