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MiR-26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2.

BACKGROUND/AIMSMiR-26a has been identified as a tumor suppressor in various tumors, but the relationship between miR-26a and the sensitivity of gastric cancer to chemotherapies has not been established. The present study was performed to investigate the effect of miR-26a on drug sensitivity in gastr... Full description

Journal Title: Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association 2015 Sep-Oct, Vol.21(5), pp.313-319
Main Author: Wen, Lan
Other Authors: Cheng, Fangzhi , Zhou, Yanyan , Yin, Chunhua
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1998-4049 ; DOI: 10.4103/1319-3767.166206
Link: http://search.proquest.com/docview/1722185589/?pq-origsite=primo
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recordid: proquest1722185589
title: MiR-26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2.
format: Article
creator:
  • Wen, Lan
  • Cheng, Fangzhi
  • Zhou, Yanyan
  • Yin, Chunhua
subjects:
  • Antineoplastic Agents–Pharmacology
  • Apoptosis–Drug Effects
  • Cell Line, Tumor–Genetics
  • Cisplatin–Pharmacology
  • Combined Modality Therapy–Genetics
  • Down-Regulation–Genetics
  • Drug Resistance, Neoplasm–Metabolism
  • E2f2 Transcription Factor–Genetics
  • Gtp Phosphohydrolases–Metabolism
  • Gene Knockdown Techniques–Genetics
  • Hek293 Cells–Metabolism
  • Humans–Administration & Dosage
  • Membrane Proteins–Genetics
  • Micrornas–Drug Therapy
  • Mutagenesis, Site-Directed–Genetics
  • Sensitivity and Specificity–Pathology
  • Stomach Neoplasms–Therapy
  • Antineoplastic Agents
  • E2f2 Transcription Factor
  • E2f2 Protein, Human
  • Mirn26a Microrna, Human
  • Membrane Proteins
  • Micrornas
  • Gtp Phosphohydrolases
  • Nras Protein, Human
  • Cisplatin
ispartof: Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association, 2015 Sep-Oct, Vol.21(5), pp.313-319
description: BACKGROUND/AIMSMiR-26a has been identified as a tumor suppressor in various tumors, but the relationship between miR-26a and the sensitivity of gastric cancer to chemotherapies has not been established. The present study was performed to investigate the effect of miR-26a on drug sensitivity in gastric...
language: eng
source:
identifier: E-ISSN: 1998-4049 ; DOI: 10.4103/1319-3767.166206
fulltext: fulltext
issn:
  • 19984049
  • 1998-4049
url: Link


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titleMiR-26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2.
creatorWen, Lan ; Cheng, Fangzhi ; Zhou, Yanyan ; Yin, Chunhua
contributorWen, Lan (correspondence author) ; Wen, Lan (record owner)
ispartofSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association, 2015 Sep-Oct, Vol.21(5), pp.313-319
identifierE-ISSN: 1998-4049 ; DOI: 10.4103/1319-3767.166206
subjectAntineoplastic Agents–Pharmacology ; Apoptosis–Drug Effects ; Cell Line, Tumor–Genetics ; Cisplatin–Pharmacology ; Combined Modality Therapy–Genetics ; Down-Regulation–Genetics ; Drug Resistance, Neoplasm–Metabolism ; E2f2 Transcription Factor–Genetics ; Gtp Phosphohydrolases–Metabolism ; Gene Knockdown Techniques–Genetics ; Hek293 Cells–Metabolism ; Humans–Administration & Dosage ; Membrane Proteins–Genetics ; Micrornas–Drug Therapy ; Mutagenesis, Site-Directed–Genetics ; Sensitivity and Specificity–Pathology ; Stomach Neoplasms–Therapy ; Antineoplastic Agents ; E2f2 Transcription Factor ; E2f2 Protein, Human ; Mirn26a Microrna, Human ; Membrane Proteins ; Micrornas ; Gtp Phosphohydrolases ; Nras Protein, Human ; Cisplatin
descriptionBACKGROUND/AIMSMiR-26a has been identified as a tumor suppressor in various tumors, but the relationship between miR-26a and the sensitivity of gastric cancer to chemotherapies has not been established. The present study was performed to investigate the effect of miR-26a on drug sensitivity in gastric...
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titleMiR-26a enhances the sensitivity of gastric cancer cells to cisplatin by targeting NRAS and E2F2.
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6Drug Resistance, Neoplasm–Metabolism
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abstractBACKGROUND/AIMSMiR-26a has been identified as a tumor suppressor in various tumors, but the relationship between miR-26a and the sensitivity of gastric cancer to chemotherapies has not been established. The present study was performed to investigate the effect of miR-26a on drug sensitivity in gastric...
doi10.4103/1319-3767.166206
urlhttp://search.proquest.com/docview/1722185589/
issn13193767
date2015-09-01