schliessen

Filtern

 

Bibliotheken

Mediterranean Diet, Retinopathy, Nephropathy, and Microvascular Diabetes Complications: A Post Hoc Analysis of a Randomized Trial.

OBJECTIVETo date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephrop... Full description

Journal Title: Diabetes care November 2015, Vol.38(11), pp.2134-2141
Main Author: Díaz-López, Andrés
Other Authors: Babio, Nancy , Martínez-González, Miguel A , Corella, Dolores , Amor, Antonio J , Fitó, Montse , Estruch, Ramon , Arós, Fernando , Gómez-Gracia, Enrique , Fiol, Miquel , Lapetra, José , Serra-Majem, Lluís , Basora, Josep , Basterra-Gortari, F Javier , Zanon-Moreno, Vicente , Muñoz, Miguel Ángel , Salas-Salvadó, Jordi , Díaz-López, Andrés
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1935-5548 ; DOI: 1935-5548 ; DOI: 10.2337/dc15-1117
Link: http://search.proquest.com/docview/1727435708/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1727435708
title: Mediterranean Diet, Retinopathy, Nephropathy, and Microvascular Diabetes Complications: A Post Hoc Analysis of a Randomized Trial.
format: Article
creator:
  • Díaz-López, Andrés
  • Babio, Nancy
  • Martínez-González, Miguel A
  • Corella, Dolores
  • Amor, Antonio J
  • Fitó, Montse
  • Estruch, Ramon
  • Arós, Fernando
  • Gómez-Gracia, Enrique
  • Fiol, Miquel
  • Lapetra, José
  • Serra-Majem, Lluís
  • Basora, Josep
  • Basterra-Gortari, F Javier
  • Zanon-Moreno, Vicente
  • Muñoz, Miguel Ángel
  • Salas-Salvadó, Jordi
  • Díaz-López, Andrés
subjects:
  • Aged–Diet Therapy
  • Aged, 80 and Over–Epidemiology
  • Cardiovascular Diseases–Diet Therapy
  • Diabetes Mellitus, Type 2–Epidemiology
  • Diabetic Angiopathies–Diet Therapy
  • Diabetic Nephropathies–Epidemiology
  • Diabetic Retinopathy–Diet Therapy
  • Diet, Mediterranean–Epidemiology
  • Female–Diet Therapy
  • Humans–Epidemiology
  • Incidence–Epidemiology
  • Male–Epidemiology
  • Microvessels–Epidemiology
  • Middle Aged–Epidemiology
  • Nuts–Epidemiology
  • Risk Factors–Epidemiology
ispartof: Diabetes care, November 2015, Vol.38(11), pp.2134-2141
description: OBJECTIVETo date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephropathy than a low-fat control diet. RESEARCH DESIGN AND METHODSThis was a post hoc analysis of a cohort of patients with type 2 diabetes participating in the PREvención con DIeta MEDiterránea (PREDIMED) study, a multicenter randomized nutritional intervention trial conducted in a population at high cardiovascular risk. Individuals with type 2 diabetes who were free of microvascular complications at enrollment (n = 3,614, aged 55-80 years) were randomly assigned to one of three dietary interventions: MedDiet supplemented with extravirgin olive oil (MedDiet+EVOO), MedDiet supplemented with mixed nuts (MedDiet+Nuts), or a low-fat control diet. Two independent outcomes were considered: new onset of diabetic retinopathy and nephropathy. Hazard ratios (HRs) were calculated using multivariable-adjusted Cox regression. RESULTSDuring a median follow-up of 6.0 years, we identified 74 new cases of retinopathy and 168 of nephropathy. Compared with the control diet, multivariable-adjusted HRs for diabetic retinopathy were 0.56 (95% CI 0.32-0.97) for the MedDiet+EVOO and 0.63 (0.35-1.11) for the MedDiet+Nuts. No between-group differences were found for nephropathy. When the yearly updated information on adherence to the MedDiet was considered, the HR for retinopathy in the highest versus the lowest quintile was 0.34 (0.13-0.89; P = 0.001 for trend). No significant associations were found for nephropathy. CONCLUSIONSA MedDiet enriched with EVOO may protect against diabetic retinopathy but not diabetic nephropathy.
language: eng
source:
identifier: E-ISSN: 1935-5548 ; DOI: 1935-5548 ; DOI: 10.2337/dc15-1117
fulltext: fulltext
issn:
  • 19355548
  • 1935-5548
url: Link


@attributes
ID1377364251
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1727435708
sourceidproquest
recordidTN_proquest1727435708
sourcesystemOther
pqid1727435708
galeid434880713
display
typearticle
titleMediterranean Diet, Retinopathy, Nephropathy, and Microvascular Diabetes Complications: A Post Hoc Analysis of a Randomized Trial.
creatorDíaz-López, Andrés ; Babio, Nancy ; Martínez-González, Miguel A ; Corella, Dolores ; Amor, Antonio J ; Fitó, Montse ; Estruch, Ramon ; Arós, Fernando ; Gómez-Gracia, Enrique ; Fiol, Miquel ; Lapetra, José ; Serra-Majem, Lluís ; Basora, Josep ; Basterra-Gortari, F Javier ; Zanon-Moreno, Vicente ; Muñoz, Miguel Ángel ; Salas-Salvadó, Jordi ; Díaz-López, Andrés
contributorToledo, E (correspondence author) ; Ruiz-Canela, M (record owner) ; Sanjulian, B ; Sánchez-Tainta, A ; Eguaras, S ; Marti, A ; Buil-Cosiales, P ; Serrano-Martínez, M ; Diez-Espino, J ; García-Arellano, A ; Martínez-Lapiscina, E H ; Goñi, E ; Vázquez, Z ; Berrade, N ; Extremera-Urabayen, V ; Arroyo-Azpa, C ; García-Perez, L ; Villanueva Telleria, J ; Cortes Ugalde, F ; Sagredo Arce, T ; García de La Noceda Montoy, M D ; Vigata López, M D ; Arceiz Campo, M T ; Urtasun Samper, A ; Gueto Rubio, M V ; Churio Beraza, B ; Serra, M ; Perez-Heras, A ; Vinas, C ; Casas, R ; de Santamaria, L ; Romero, S ; Baena, J M ; García, M ; Oller, M ; Amat, J ; Duaso, I ; García, Y ; Iglesias, C ; Simon, C ; Quinzavos, Ll ; Parra, Ll ; Liroz, M ; Benavent, J ; Clos, J ; Pla, I ; Amoros, M ; Bonet, M T ; Martin, M T ; Sanchez, M S ; Altirruba, J ; Manzano, E ; Altes, A ; Cofan, M ; Valls-Pedret, C ; Sala-Vila, A ; Domenech, M ; Bullo, M ; González, R ; Molina, C ; Márquez, F ; Martínez, P ; Ibarrola, N ; Sorli, M ; García Roselló, J ; Castro, A ; Martin, F ; Tort, N ; Isach, A ; Guasch-Ferre, M ; Becerra-Tomás, N ; Cabre, J J ; Mestres, G ; Paris, F ; Llauradó, M ; Pedret, R ; Basells, J ; Vizcaino, J ; Segarra, R ; Romero-Aroca, P ; Fernández-Ballart, J ; Tello, S ; Vila, J ; de La Torre, R ; Munoz-Aguayo, D ; Elosua, R ; Marrugat, J ; Schröder, H ; Molina, N ; Maestre, E ; Rovira, A ; Castañer, O ; Ferrer, M ; Carrasco, P ; Ortega-Azorín, C ; Asensio, E M ; Osma, R ; Barragán, R ; Francés, F ; Guillén, M ; González, J I ; Saiz, C ; Portolés, O ; Giménez, F J ; Coltell, O ; Guillem-Saiz, P ; Quiles, L ; Pascual, V ; Riera, C ; Pages, M A ; Godoy, D ; Carratalá-Calvo, A ; Martín-Rillo, M J ; Llopis-Osorio, E ; Ruiz-Baixauli, J ; Bertolín-Muñoz, A ; Salaverria, I ; Del Hierro, T ; Algorta, J ; Francisco, S ; Alonso-Gómez, A ; Sanz, E ; Rekondo, J ; Belló, M C ; Loma-Osorio, A ; Gómez-Gracia, E ; Wärnberg, J ; Benitez Pont, R ; Bianchi Alba, M ; Gomez-Huelgas, R ; Martínez-González, J ; Velasco García, V ; de Diego Salas, J ; Baca Osorio, A ; Gil Zarzosa, J ; Sánchez Luque, J J ; Vargas López, E ; Sánchez Perona, J ; Montero Romero, E ; García-García, M ; Jurado-Ruiz, E ; García-Valdueza, M ; Moñino, M ; Proenza, A ; Prieto, R ; Frontera, G ; Ginard, M ; Fiol, F ; Jover, A ; Romaguera, D ; García, J ; Lapetra, J ; Leal, M ; Martínez, E ; Ortega-Calvo, M ; Roman, P ; Jose García, F ; Iglesias, P ; Corchado, Y ; Mayoral, E ; Mellado, L ; Miró, L ; Lozano, J M ; Lama, C ; López-Sabater, M C ; Castellote-Bargallo, A I ; Medina-Remon, A ; Tresserra-Rimbau, A ; Alvarez-Perez, J ; Diez Benitez, E ; Bautista Castaño, I ; Maldonado Diaz, I ; Sanchez-Villegas, A ; Férnandez-Rodríguez, M J ; Sarmiendo de La Fe, F ; Simon García, C ; Falcon Sanabria, I ; Macias Gutierrez, B ; Santana Santana, A J ; de La Cruz, E ; Galera, A ; Soler, Y ; Trias, F ; Sarasa, I ; Padres, E ; Corbella, E ; Cabezas, C ; Vinyoles, E ; Rovira, M A ; García, L ; Flores, G ; Verdu, J M ; Baby, P ; Ramos, A ; Mengual, L ; Roura, P ; Yuste, M C ; Guarner, A ; Rovira, A ; Santamaria, M I ; Mata, M ; de Juan, C ; Brau, A ; Tur, J A ; Portillo, M P ; Saez, G ; Arós, F ; Aldamiz, M ; Alonso, A ; Berjón, J ; Forga, L ; Gállego, J ; García-Layana, A ; Larrauri, A ; Portu, J ; Timiraus, J ; Serrano-Martínez, M ; Serrano-Martínez, M ; Serrano-Martínez, M
ispartofDiabetes care, November 2015, Vol.38(11), pp.2134-2141
identifier
subjectAged–Diet Therapy ; Aged, 80 and Over–Epidemiology ; Cardiovascular Diseases–Diet Therapy ; Diabetes Mellitus, Type 2–Epidemiology ; Diabetic Angiopathies–Diet Therapy ; Diabetic Nephropathies–Epidemiology ; Diabetic Retinopathy–Diet Therapy ; Diet, Mediterranean–Epidemiology ; Female–Diet Therapy ; Humans–Epidemiology ; Incidence–Epidemiology ; Male–Epidemiology ; Microvessels–Epidemiology ; Middle Aged–Epidemiology ; Nuts–Epidemiology ; Risk Factors–Epidemiology
descriptionOBJECTIVETo date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephropathy than a low-fat control diet. RESEARCH DESIGN AND METHODSThis was a post hoc analysis of a cohort of patients with type 2 diabetes participating in the PREvención con DIeta MEDiterránea (PREDIMED) study, a multicenter randomized nutritional intervention trial conducted in a population at high cardiovascular risk. Individuals with type 2 diabetes who were free of microvascular complications at enrollment (n = 3,614, aged 55-80 years) were randomly assigned to one of three dietary interventions: MedDiet supplemented with extravirgin olive oil (MedDiet+EVOO), MedDiet supplemented with mixed nuts (MedDiet+Nuts), or a low-fat control diet. Two independent outcomes were considered: new onset of diabetic retinopathy and nephropathy. Hazard ratios (HRs) were calculated using multivariable-adjusted Cox regression. RESULTSDuring a median follow-up of 6.0 years, we identified 74 new cases of retinopathy and 168 of nephropathy. Compared with the control diet, multivariable-adjusted HRs for diabetic retinopathy were 0.56 (95% CI 0.32-0.97) for the MedDiet+EVOO and 0.63 (0.35-1.11) for the MedDiet+Nuts. No between-group differences were found for nephropathy. When the yearly updated information on adherence to the MedDiet was considered, the HR for retinopathy in the highest versus the lowest quintile was 0.34 (0.13-0.89; P = 0.001 for trend). No significant associations were found for nephropathy. CONCLUSIONSA MedDiet enriched with EVOO may protect against diabetic retinopathy but not diabetic nephropathy.
languageeng
source
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1727435708/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Díaz-López, Andrés
1Babio, Nancy
2Martínez-González, Miguel A
3Corella, Dolores
4Amor, Antonio J
5Fitó, Montse
6Estruch, Ramon
7Arós, Fernando
8Gómez-Gracia, Enrique
9Fiol, Miquel
10Lapetra, José
11Serra-Majem, Lluís
12Basora, Josep
13Basterra-Gortari, F Javier
14Zanon-Moreno, Vicente
15Muñoz, Miguel Ángel
16Salas-Salvadó, Jordi
titleMediterranean Diet, Retinopathy, Nephropathy, and Microvascular Diabetes Complications: A Post Hoc Analysis of a Randomized Trial.
descriptionOBJECTIVETo date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephropathy than a low-fat control diet. RESEARCH DESIGN AND METHODSThis was a post hoc analysis of a cohort of patients with type 2 diabetes participating in the PREvención con DIeta MEDiterránea (PREDIMED) study, a multicenter randomized nutritional intervention trial conducted in a population at high cardiovascular risk. Individuals with type 2 diabetes who were free of microvascular complications at enrollment (n = 3,614, aged 55-80 years) were randomly assigned to one of three dietary interventions: MedDiet supplemented with extravirgin olive oil (MedDiet+EVOO), MedDiet supplemented with mixed nuts (MedDiet+Nuts), or a low-fat control diet. Two independent outcomes were considered: new onset of diabetic retinopathy and nephropathy. Hazard ratios (HRs) were calculated using multivariable-adjusted Cox regression. RESULTSDuring a median follow-up of 6.0 years, we identified 74 new cases of retinopathy and 168 of nephropathy. Compared with the control diet, multivariable-adjusted HRs for diabetic retinopathy were 0.56 (95% CI 0.32-0.97) for the MedDiet+EVOO and 0.63 (0.35-1.11) for the MedDiet+Nuts. No between-group differences were found for nephropathy. When the yearly updated information on adherence to the MedDiet was considered, the HR for retinopathy in the highest versus the lowest quintile was 0.34 (0.13-0.89; P = 0.001 for trend). No significant associations were found for nephropathy. CONCLUSIONSA MedDiet enriched with EVOO may protect against diabetic retinopathy but not diabetic nephropathy.
subject
0Aged–Diet Therapy
1Aged, 80 and Over–Epidemiology
2Cardiovascular Diseases–Diet Therapy
3Diabetes Mellitus, Type 2–Epidemiology
4Diabetic Angiopathies–Diet Therapy
5Diabetic Nephropathies–Epidemiology
6Diabetic Retinopathy–Diet Therapy
7Diet, Mediterranean–Epidemiology
8Female–Diet Therapy
9Humans–Epidemiology
10Incidence–Epidemiology
11Male–Epidemiology
12Microvessels–Epidemiology
13Middle Aged–Epidemiology
14Nuts–Epidemiology
15Risk Factors–Epidemiology
16ISRCTN35739639
17ISRCTN
general
0English
11935-5548
210.2337/dc15-1117
3MEDLINE (ProQuest)
4ProQuest Biological Science Collection
5ProQuest Natural Science Collection
6ProQuest SciTech Collection
7Biological Science Database
8Natural Science Collection
9SciTech Premium Collection
10Health Research Premium Collection
11Health Research Premium Collection (Alumni edition)
sourceidproquest
recordidproquest1727435708
issn
019355548
11935-5548
rsrctypearticle
creationdate2015
addtitleDiabetes care
searchscope
01007527
11007944
210000004
310000038
410000050
510000120
610000159
710000238
810000253
910000260
1010000270
1110000271
1210000302
13proquest
scope
01007527
11007944
210000004
310000038
410000050
510000120
610000159
710000238
810000253
910000260
1010000270
1110000271
1210000302
13proquest
lsr43
01007527false
11007944false
210000004false
310000038false
410000050false
510000120false
610000159false
710000238false
810000253false
910000260false
1010000270false
1110000271false
1210000302false
contributor
0Toledo, E
1Ruiz-Canela, M
2Sanjulian, B
3Sánchez-Tainta, A
4Eguaras, S
5Marti, A
6Buil-Cosiales, P
7Serrano-Martínez, M
8Diez-Espino, J
9García-Arellano, A
10Martínez-Lapiscina, E H
11Goñi, E
12Vázquez, Z
13Berrade, N
14Extremera-Urabayen, V
15Arroyo-Azpa, C
16García-Perez, L
17Villanueva Telleria, J
18Cortes Ugalde, F
19Sagredo Arce, T
20García de La Noceda Montoy, M D
21Vigata López, M D
22Arceiz Campo, M T
23Urtasun Samper, A
24Gueto Rubio, M V
25Churio Beraza, B
26Serra, M
27Perez-Heras, A
28Vinas, C
29Casas, R
30de Santamaria, L
31Romero, S
32Baena, J M
33García, M
34Oller, M
35Amat, J
36Duaso, I
37García, Y
38Iglesias, C
39Simon, C
40Quinzavos, Ll
41Parra, Ll
42Liroz, M
43Benavent, J
44Clos, J
45Pla, I
46Amoros, M
47Bonet, M T
48Martin, M T
49Sanchez, M S
50Altirruba, J
51Manzano, E
52Altes, A
53Cofan, M
54Valls-Pedret, C
55Sala-Vila, A
56Domenech, M
57Bullo, M
58González, R
59Molina, C
60Márquez, F
61Martínez, P
62Ibarrola, N
63Sorli, M
64García Roselló, J
65Castro, A
66Martin, F
67Tort, N
68Isach, A
69Guasch-Ferre, M
70Becerra-Tomás, N
71Cabre, J J
72Mestres, G
73Paris, F
74Llauradó, M
75Pedret, R
76Basells, J
77Vizcaino, J
78Segarra, R
79Romero-Aroca, P
80Fernández-Ballart, J
81Tello, S
82Vila, J
83de La Torre, R
84Munoz-Aguayo, D
85Elosua, R
86Marrugat, J
87Schröder, H
88Molina, N
89Maestre, E
90Rovira, A
91Castañer, O
92Ferrer, M
93Carrasco, P
94Ortega-Azorín, C
95Asensio, E M
96Osma, R
97Barragán, R
98Francés, F
99Guillén, M
100...
startdate20151101
enddate20151101
citationpf 2134 pt 2141 vol 38 issue 11
lsr30VSR-Enriched:[pqid, galeid, issn]
sort
titleMediterranean Diet, Retinopathy, Nephropathy, and Microvascular Diabetes Complications: A Post Hoc Analysis of a Randomized Trial.
authorDíaz-López, Andrés ; Babio, Nancy ; Martínez-González, Miguel A ; Corella, Dolores ; Amor, Antonio J ; Fitó, Montse ; Estruch, Ramon ; Arós, Fernando ; Gómez-Gracia, Enrique ; Fiol, Miquel ; Lapetra, José ; Serra-Majem, Lluís ; Basora, Josep ; Basterra-Gortari, F Javier ; Zanon-Moreno, Vicente ; Muñoz, Miguel Ángel ; Salas-Salvadó, Jordi ; Díaz-López, Andrés
creationdate20151101
lso0120151101
facets
frbrgroupid8543109076762963915
frbrtype5
newrecords20181218
languageeng
creationdate2015
topic
0Aged–Diet Therapy
1Aged, 80 and Over–Epidemiology
2Cardiovascular Diseases–Diet Therapy
3Diabetes Mellitus, Type 2–Epidemiology
4Diabetic Angiopathies–Diet Therapy
5Diabetic Nephropathies–Epidemiology
6Diabetic Retinopathy–Diet Therapy
7Diet, Mediterranean–Epidemiology
8Female–Diet Therapy
9Humans–Epidemiology
10Incidence–Epidemiology
11Male–Epidemiology
12Microvessels–Epidemiology
13Middle Aged–Epidemiology
14Nuts–Epidemiology
15Risk Factors–Epidemiology
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
prefilterarticles
rsrctypearticles
creatorcontrib
0Díaz-López, Andrés
1Babio, Nancy
2Martínez-González, Miguel A
3Corella, Dolores
4Amor, Antonio J
5Fitó, Montse
6Estruch, Ramon
7Arós, Fernando
8Gómez-Gracia, Enrique
9Fiol, Miquel
10Lapetra, José
11Serra-Majem, Lluís
12Basora, Josep
13Basterra-Gortari, F Javier
14Zanon-Moreno, Vicente
15Muñoz, Miguel Ángel
16Salas-Salvadó, Jordi
17Toledo, E
18Ruiz-Canela, M
19Sanjulian, B
20Sánchez-Tainta, A
21Eguaras, S
22Marti, A
23Buil-Cosiales, P
24Serrano-Martínez, M
25Diez-Espino, J
26García-Arellano, A
27Martínez-Lapiscina, E H
28Goñi, E
29Vázquez, Z
30Berrade, N
31Extremera-Urabayen, V
32Arroyo-Azpa, C
33García-Perez, L
34Villanueva Telleria, J
35Cortes Ugalde, F
36Sagredo Arce, T
37García de La Noceda Montoy, M D
38Vigata López, M D
39Arceiz Campo, M T
40Urtasun Samper, A
41Gueto Rubio, M V
42Churio Beraza, B
43Serra, M
44Perez-Heras, A
45Vinas, C
46Casas, R
47de Santamaria, L
48Romero, S
49Baena, J M
50García, M
51Oller, M
52Amat, J
53Duaso, I
54García, Y
55Iglesias, C
56Simon, C
57Quinzavos, Ll
58Parra, Ll
59Liroz, M
60Benavent, J
61Clos, J
62Pla, I
63Amoros, M
64Bonet, M T
65Martin, M T
66Sanchez, M S
67Altirruba, J
68Manzano, E
69Altes, A
70Cofan, M
71Valls-Pedret, C
72Sala-Vila, A
73Domenech, M
74Bullo, M
75González, R
76Molina, C
77Márquez, F
78Martínez, P
79Ibarrola, N
80Sorli, M
81García Roselló, J
82Castro, A
83Martin, F
84Tort, N
85Isach, A
86Guasch-Ferre, M
87Becerra-Tomás, N
88Cabre, J J
89Mestres, G
90Paris, F
91Llauradó, M
92Pedret, R
93Basells, J
94Vizcaino, J
95Segarra, R
96Romero-Aroca, P
97Fernández-Ballart, J
98Tello, S
99Vila, J
100...
jtitleDiabetes care
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Díaz-López
1Babio
2Martínez-González
3Corella
4Amor
5Fitó
6Estruch
7Arós
8Gómez-Gracia
9Fiol
10Lapetra
11Serra-Majem
12Basora
13Basterra-Gortari
14Zanon-Moreno
15Muñoz
16Salas-Salvadó
aufirst
0Andrés
1Nancy
2Miguel A
3Dolores
4Antonio J
5Montse
6Ramon
7Fernando
8Enrique
9Miquel
10José
11Lluís
12Josep
13F Javier
14Vicente
15Miguel Ángel
16Jordi
au
0Díaz-López, Andrés
1Babio, Nancy
2Martínez-González, Miguel A
3Corella, Dolores
4Amor, Antonio J
5Fitó, Montse
6Estruch, Ramon
7Arós, Fernando
8Gómez-Gracia, Enrique
9Fiol, Miquel
10Lapetra, José
11Serra-Majem, Lluís
12Basora, Josep
13Basterra-Gortari, F Javier
14Zanon-Moreno, Vicente
15Muñoz, Miguel Ángel
16Salas-Salvadó, Jordi
addau
0Toledo, E
1Ruiz-Canela, M
2Sanjulian, B
3Sánchez-Tainta, A
4Eguaras, S
5Marti, A
6Buil-Cosiales, P
7Serrano-Martínez, M
8Diez-Espino, J
9García-Arellano, A
10Martínez-Lapiscina, E H
11Goñi, E
12Vázquez, Z
13Berrade, N
14Extremera-Urabayen, V
15Arroyo-Azpa, C
16García-Perez, L
17Villanueva Telleria, J
18Cortes Ugalde, F
19Sagredo Arce, T
20García de la Noceda Montoy, M D
21Vigata López, M D
22Arceiz Campo, M T
23Urtasun Samper, A
24Gueto Rubio, M V
25Churio Beraza, B
26Serra, M
27Perez-Heras, A
28Vinas, C
29Casas, R
30de Santamaria, L
31Romero, S
32Baena, J M
33García, M
34Oller, M
35Amat, J
36Duaso, I
37García, Y
38Iglesias, C
39Simon, C
40Quinzavos, Ll
41Parra, Ll
42Liroz, M
43Benavent, J
44Clos, J
45Pla, I
46Amoros, M
47Bonet, M T
48Martin, M T
49Sanchez, M S
50Altirruba, J
51Manzano, E
52Altes, A
53Cofan, M
54Valls-Pedret, C
55Sala-Vila, A
56Domenech, M
57Bullo, M
58González, R
59Molina, C
60Márquez, F
61Martínez, P
62Ibarrola, N
63Sorli, M
64García Roselló, J
65Castro, A
66Martin, F
67Tort, N
68Isach, A
69Guasch-Ferre, M
70Becerra-Tomás, N
71Cabre, J J
72Mestres, G
73Paris, F
74Llauradó, M
75Pedret, R
76Basells, J
77Vizcaino, J
78Segarra, R
79Romero-Aroca, P
80Fernández-Ballart, J
81Tello, S
82Vila, J
83de la Torre, R
84Munoz-Aguayo, D
85Elosua, R
86Marrugat, J
87Schröder, H
88Molina, N
89maestre, E
90Rovira, A
91Castañer, O
92Ferrer, M
93Carrasco, P
94Ortega-Azorín, C
95Asensio, E M
96Osma, R
97Barragán, R
98Francés, F
99Guillén, M
100...
atitleMediterranean Diet, Retinopathy, Nephropathy, and Microvascular Diabetes Complications: A Post Hoc Analysis of a Randomized Trial.
jtitleDiabetes care
risdate20151101
volume38
issue11
spage2134
epage2141
pages2134-2141
eissn1935-5548
formatjournal
genrearticle
ristypeJOUR
abstractOBJECTIVETo date no clinical trials have evaluated the role of dietary patterns on the incidence of microvascular diabetes complications. We hypothesized that a nutritional intervention based on the Mediterranean diet (MedDiet) would have greater protective effect on diabetic retinopathy and nephropathy than a low-fat control diet. RESEARCH DESIGN AND METHODSThis was a post hoc analysis of a cohort of patients with type 2 diabetes participating in the PREvención con DIeta MEDiterránea (PREDIMED) study, a multicenter randomized nutritional intervention trial conducted in a population at high cardiovascular risk. Individuals with type 2 diabetes who were free of microvascular complications at enrollment (n = 3,614, aged 55-80 years) were randomly assigned to one of three dietary interventions: MedDiet supplemented with extravirgin olive oil (MedDiet+EVOO), MedDiet supplemented with mixed nuts (MedDiet+Nuts), or a low-fat control diet. Two independent outcomes were considered: new onset of diabetic retinopathy and nephropathy. Hazard ratios (HRs) were calculated using multivariable-adjusted Cox regression. RESULTSDuring a median follow-up of 6.0 years, we identified 74 new cases of retinopathy and 168 of nephropathy. Compared with the control diet, multivariable-adjusted HRs for diabetic retinopathy were 0.56 (95% CI 0.32-0.97) for the MedDiet+EVOO and 0.63 (0.35-1.11) for the MedDiet+Nuts. No between-group differences were found for nephropathy. When the yearly updated information on adherence to the MedDiet was considered, the HR for retinopathy in the highest versus the lowest quintile was 0.34 (0.13-0.89; P = 0.001 for trend). No significant associations were found for nephropathy. CONCLUSIONSA MedDiet enriched with EVOO may protect against diabetic retinopathy but not diabetic nephropathy.
doi10.2337/dc15-1117
urlhttp://search.proquest.com/docview/1727435708/
issn01495992
date2015-11-01