schliessen

Filtern

 

Bibliotheken

Reduced grid-cell-like representations in adults at genetic risk for Alzheimer's disease.

Early signs of dementiaThere is currently no cure for Alzheimer's disease. One of the reasons could be that interventions start too late, when there is already irreversible damage to the brain. Developing a biomarker that would help to effectively start therapy at very early stages of the disease is... Full description

Journal Title: Science (New York N.Y.), October 23, 2015, Vol.350(6259), pp.430-433
Main Author: Kunz, Lukas
Other Authors: Schröder, Tobias Navarro , Lee, Hweeling , Montag, Christian , Lachmann, Bernd , Sariyska, Rayna , Reuter, Martin , Stirnberg, Rüdiger , Stöcker, Tony , Messing-Floeter, Paul Christian , Fell, Juergen , Doeller, Christian F , Axmacher, Nikolai
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1095-9203 ; DOI: 10.1126/science.aac8128
Link: http://search.proquest.com/docview/1727439501/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1727439501
title: Reduced grid-cell-like representations in adults at genetic risk for Alzheimer's disease.
format: Article
creator:
  • Kunz, Lukas
  • Schröder, Tobias Navarro
  • Lee, Hweeling
  • Montag, Christian
  • Lachmann, Bernd
  • Sariyska, Rayna
  • Reuter, Martin
  • Stirnberg, Rüdiger
  • Stöcker, Tony
  • Messing-Floeter, Paul Christian
  • Fell, Juergen
  • Doeller, Christian F
  • Axmacher, Nikolai
subjects:
  • Adult–Genetics
  • Age of Onset–Pathology
  • Alzheimer Disease–Psychology
  • Apolipoprotein E4–Genetics
  • Entorhinal Cortex–Pathology
  • Female–Physiopathology
  • Heterozygote–Physiopathology
  • Hippocampus–Physiopathology
  • Humans–Physiopathology
  • Magnetic Resonance Imaging–Physiopathology
  • Male–Physiopathology
  • Risk Factors–Physiopathology
  • Spatial Memory–Physiopathology
  • Spatial Navigation–Physiopathology
  • Young Adult–Physiopathology
  • Apolipoprotein E4
ispartof: Science (New York, N.Y.), October 23, 2015, Vol.350(6259), pp.430-433
description: Early signs of dementiaThere is currently no cure for Alzheimer's disease. One of the reasons could be that interventions start too late, when there is already irreversible damage to the brain. Developing a biomarker that would help to effectively start therapy at very early stages of the disease is thus of high interest. Kunz et al. studied neural correlates of spatial navigation in the entorhinal cortex in control study participants and individuals at risk of developing Alzheimer's. The at-risk group showed a different brain signal many decades before the onset of the disease, and they navigated differently in a virtual environment.Science, this issue p. 430 Alzheimer's disease (AD) manifests with memory loss and spatial disorientation. AD pathology starts in the entorhinal cortex, making it likely that local neural correlates of spatial navigation, particularly grid cells, are impaired. Grid-cell-like representations in humans can be measured using functional magnetic resonance imaging. We found that young adults at genetic risk for AD (APOE- epsilon 4 carriers) exhibit reduced grid-cell-like representations and altered navigational behavior in a virtual arena. Both changes were associated with impaired spatial memory performance. Reduced grid-cell-like representations were also related to increased hippocampal activity, potentially reflecting compensatory mechanisms that prevent overt spatial memory impairment in APOE- epsilon 4 carriers. Our results provide evidence of behaviorally relevant entorhinal dysfunction in humans at genetic risk for AD, decades before potential disease onset.
language: eng
source:
identifier: E-ISSN: 1095-9203 ; DOI: 10.1126/science.aac8128
fulltext: no_fulltext
issn:
  • 10959203
  • 1095-9203
url: Link


@attributes
ID124865829
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1727439501
sourceidproquest
recordidTN_proquest1727439501
sourcesystemPC
pqid1727439501
galeid433685095
display
typearticle
titleReduced grid-cell-like representations in adults at genetic risk for Alzheimer's disease.
creatorKunz, Lukas ; Schröder, Tobias Navarro ; Lee, Hweeling ; Montag, Christian ; Lachmann, Bernd ; Sariyska, Rayna ; Reuter, Martin ; Stirnberg, Rüdiger ; Stöcker, Tony ; Messing-Floeter, Paul Christian ; Fell, Juergen ; Doeller, Christian F ; Axmacher, Nikolai
contributorKunz, Lukas (correspondence author) ; Kunz, Lukas (record owner)
ispartofScience (New York, N.Y.), October 23, 2015, Vol.350(6259), pp.430-433
identifierE-ISSN: 1095-9203 ; DOI: 10.1126/science.aac8128
subjectAdult–Genetics ; Age of Onset–Pathology ; Alzheimer Disease–Psychology ; Apolipoprotein E4–Genetics ; Entorhinal Cortex–Pathology ; Female–Physiopathology ; Heterozygote–Physiopathology ; Hippocampus–Physiopathology ; Humans–Physiopathology ; Magnetic Resonance Imaging–Physiopathology ; Male–Physiopathology ; Risk Factors–Physiopathology ; Spatial Memory–Physiopathology ; Spatial Navigation–Physiopathology ; Young Adult–Physiopathology ; Apolipoprotein E4
languageeng
source
descriptionEarly signs of dementiaThere is currently no cure for Alzheimer's disease. One of the reasons could be that interventions start too late, when there is already irreversible damage to the brain. Developing a biomarker that would help to effectively start therapy at very early stages of the disease is thus of high interest. Kunz et al. studied neural correlates of spatial navigation in the entorhinal cortex in control study participants and individuals at risk of developing Alzheimer's. The at-risk group showed a different brain signal many decades before the onset of the disease, and they navigated differently in a virtual environment.Science, this issue p. 430 Alzheimer's disease (AD) manifests with memory loss and spatial disorientation. AD pathology starts in the entorhinal cortex, making it likely that local neural correlates of spatial navigation, particularly grid cells, are impaired. Grid-cell-like representations in humans can be measured using functional magnetic resonance imaging. We found that young adults at genetic risk for AD (APOE- epsilon 4 carriers) exhibit reduced grid-cell-like representations and altered navigational behavior in a virtual arena. Both changes were associated with impaired spatial memory performance. Reduced grid-cell-like representations were also related to increased hippocampal activity, potentially reflecting compensatory mechanisms that prevent overt spatial memory impairment in APOE- epsilon 4 carriers. Our results provide evidence of behaviorally relevant entorhinal dysfunction in humans at genetic risk for AD, decades before potential disease onset.
version9
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1727439501/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Kunz, Lukas
1Schröder, Tobias Navarro
2Lee, Hweeling
3Montag, Christian
4Lachmann, Bernd
5Sariyska, Rayna
6Reuter, Martin
7Stirnberg, Rüdiger
8Stöcker, Tony
9Messing-Floeter, Paul Christian
10Fell, Juergen
11Doeller, Christian F
12Axmacher, Nikolai
titleReduced grid-cell-like representations in adults at genetic risk for Alzheimer's disease.
subject
0Adult–Genetics
1Age of Onset–Pathology
2Alzheimer Disease–Psychology
3Apolipoprotein E4–Genetics
4Entorhinal Cortex–Pathology
5Female–Physiopathology
6Heterozygote–Physiopathology
7Hippocampus–Physiopathology
8Humans–Physiopathology
9Magnetic Resonance Imaging–Physiopathology
10Male–Physiopathology
11Risk Factors–Physiopathology
12Spatial Memory–Physiopathology
13Spatial Navigation–Physiopathology
14Young Adult–Physiopathology
15Apolipoprotein E4
general
0English
110.1126/science.aac8128
2MEDLINE (ProQuest)
3ProQuest Biological Science Collection
4ProQuest Natural Science Collection
5ProQuest SciTech Collection
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
11Biological Science Index (ProQuest)
sourceidproquest
recordidproquest1727439501
issn
010959203
11095-9203
rsrctypearticle
creationdate2015
addtitleScience (New York, N.Y.)
searchscope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
scope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
lsr43
01007527false
11007944false
21009130false
310000004false
410000038false
510000050false
610000120false
710000159false
810000238false
910000253false
1010000260false
1110000270false
1210000271false
1310000302false
1410000350false
contributorKunz, Lukas
startdate20151023
enddate20151023
citationpf 430 pt 433 vol 350 issue 6259
lsr30VSR-Enriched:[description, issn, galeid, pqid]
sort
titleReduced grid-cell-like representations in adults at genetic risk for Alzheimer's disease.
authorKunz, Lukas ; Schröder, Tobias Navarro ; Lee, Hweeling ; Montag, Christian ; Lachmann, Bernd ; Sariyska, Rayna ; Reuter, Martin ; Stirnberg, Rüdiger ; Stöcker, Tony ; Messing-Floeter, Paul Christian ; Fell, Juergen ; Doeller, Christian F ; Axmacher, Nikolai
creationdate20151023
lso0120151023
facets
frbrgroupid8309092441381588039
frbrtype5
newrecords20181218
languageeng
creationdate2015
topic
0Adult–Genetics
1Age of Onset–Pathology
2Alzheimer Disease–Psychology
3Apolipoprotein E4–Genetics
4Entorhinal Cortex–Pathology
5Female–Physiopathology
6Heterozygote–Physiopathology
7Hippocampus–Physiopathology
8Humans–Physiopathology
9Magnetic Resonance Imaging–Physiopathology
10Male–Physiopathology
11Risk Factors–Physiopathology
12Spatial Memory–Physiopathology
13Spatial Navigation–Physiopathology
14Young Adult–Physiopathology
15Apolipoprotein E4
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
9Biological Science Index (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0Kunz, Lukas
1Schröder, Tobias Navarro
2Lee, Hweeling
3Montag, Christian
4Lachmann, Bernd
5Sariyska, Rayna
6Reuter, Martin
7Stirnberg, Rüdiger
8Stöcker, Tony
9Messing-Floeter, Paul Christian
10Fell, Juergen
11Doeller, Christian F
12Axmacher, Nikolai
jtitleScience (New York, N.Y.)
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
aulast
0Kunz
1Schröder
2Lee
3Montag
4Lachmann
5Sariyska
6Reuter
7Stirnberg
8Stöcker
9Messing-Floeter
10Fell
11Doeller
12Axmacher
aufirst
0Lukas
1Tobias Navarro
2Hweeling
3Christian
4Bernd
5Rayna
6Martin
7Rüdiger
8Tony
9Paul Christian
10Juergen
11Christian F
12Nikolai
au
0Kunz, Lukas
1Schröder, Tobias Navarro
2Lee, Hweeling
3Montag, Christian
4Lachmann, Bernd
5Sariyska, Rayna
6Reuter, Martin
7Stirnberg, Rüdiger
8Stöcker, Tony
9Messing-Floeter, Paul Christian
10Fell, Juergen
11Doeller, Christian F
12Axmacher, Nikolai
addauKunz, Lukas
atitleReduced grid-cell-like representations in adults at genetic risk for Alzheimer's disease.
jtitleScience (New York, N.Y.)
risdate20151023
volume350
issue6259
spage430
epage433
pages430-433
eissn1095-9203
formatjournal
genrearticle
ristypeJOUR
doi10.1126/science.aac8128
urlhttp://search.proquest.com/docview/1727439501/
issn00368075
date2015-10-23