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LYAR promotes colorectal cancer cell mobility by activating galectin-1 expression.

Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. However, the molecular mechanisms of CRC pathogenesis are not fully understood. In this study, we report the characterization of LYAR (Ly-1 antibody reactive clone) as a key regulator of the migration and invasio... Full description

Journal Title: Oncotarget October 20, 2015, Vol.6(32), pp.32890-32901
Main Author: Wu, Yupeng
Other Authors: Liu, Ming , Li, Zhuchen , Wu, Xiao-Bin , Wang, Ying , Wang, Yadong , Nie, Min , Huang, Feifei , Ju, Junyi , Ma, Chi , Tan, Renxiang , Zen, Ke , Zhang, Chen-Yu , Fu, Keqin , Chen, Yu-Gen , Wang, Ming-Rong , Zhao, Quan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.5335
Link: http://search.proquest.com/docview/1728669753/?pq-origsite=primo
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recordid: proquest1728669753
title: LYAR promotes colorectal cancer cell mobility by activating galectin-1 expression.
format: Article
creator:
  • Wu, Yupeng
  • Liu, Ming
  • Li, Zhuchen
  • Wu, Xiao-Bin
  • Wang, Ying
  • Wang, Yadong
  • Nie, Min
  • Huang, Feifei
  • Ju, Junyi
  • Ma, Chi
  • Tan, Renxiang
  • Zen, Ke
  • Zhang, Chen-Yu
  • Fu, Keqin
  • Chen, Yu-Gen
  • Wang, Ming-Rong
  • Zhao, Quan
subjects:
  • Binding Sites–Genetics
  • Cell Movement–Metabolism
  • Chromatin Immunoprecipitation–Pathology
  • Colorectal Neoplasms–Genetics
  • DNA-Binding Proteins–Metabolism
  • Galectin 1–Genetics
  • Gene Expression Profiling–Metabolism
  • Gene Expression Regulation, Neoplastic–Genetics
  • Genes, Reporter–Metabolism
  • Hct116 Cells–Metabolism
  • Humans–Metabolism
  • Immunohistochemistry–Metabolism
  • Neoplasm Invasiveness–Metabolism
  • Nuclear Proteins–Metabolism
  • Promoter Regions, Genetic–Metabolism
  • RNA Interference–Metabolism
  • Transfection–Metabolism
  • Up-Regulation–Metabolism
  • DNA-Binding Proteins
  • Galectin 1
ispartof: Oncotarget, October 20, 2015, Vol.6(32), pp.32890-32901
description: Colorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. However, the molecular mechanisms of CRC pathogenesis are not fully understood. In this study, we report the characterization of LYAR (Ly-1 antibody reactive clone) as a key regulator of the migration and invasion of human CRC cells. Immunohistochemistry analysis demonstrated that LYAR is expressed at a higher level in metastatic CRC tissues. We found that LYAR promoted the migratory and invasive capabilities of CRC cells. Gene expression profile analysis of CRC cells showed that LGALS1, which encodes the galectin-1 protein, was a potential target of LYAR. The ChIP assay and gene reporter assays indicated that LYAR directly bound to the LGALS1 promoter. The ectopic expression of galectin-1 partially restored the mobile potential of LYAR knocked-down cells, which suggests that galectin-1 contributed to the LYAR-promoted cell migration and invasion of CRC cells. Thus, this study revealed a novel mechanism...
language: eng
source:
identifier: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.5335
fulltext: fulltext
issn:
  • 19492553
  • 1949-2553
url: Link


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titleLYAR promotes colorectal cancer cell mobility by activating galectin-1 expression.
creatorWu, Yupeng ; Liu, Ming ; Li, Zhuchen ; Wu, Xiao-Bin ; Wang, Ying ; Wang, Yadong ; Nie, Min ; Huang, Feifei ; Ju, Junyi ; Ma, Chi ; Tan, Renxiang ; Zen, Ke ; Zhang, Chen-Yu ; Fu, Keqin ; Chen, Yu-Gen ; Wang, Ming-Rong ; Zhao, Quan
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ispartofOncotarget, October 20, 2015, Vol.6(32), pp.32890-32901
identifierE-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.5335
subjectBinding Sites–Genetics ; Cell Movement–Metabolism ; Chromatin Immunoprecipitation–Pathology ; Colorectal Neoplasms–Genetics ; DNA-Binding Proteins–Metabolism ; Galectin 1–Genetics ; Gene Expression Profiling–Metabolism ; Gene Expression Regulation, Neoplastic–Genetics ; Genes, Reporter–Metabolism ; Hct116 Cells–Metabolism ; Humans–Metabolism ; Immunohistochemistry–Metabolism ; Neoplasm Invasiveness–Metabolism ; Nuclear Proteins–Metabolism ; Promoter Regions, Genetic–Metabolism ; RNA Interference–Metabolism ; Transfection–Metabolism ; Up-Regulation–Metabolism ; DNA-Binding Proteins ; Galectin 1
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descriptionColorectal cancer (CRC) is one of the leading causes of cancer-related death worldwide. However, the molecular mechanisms of CRC pathogenesis are not fully understood. In this study, we report the characterization of LYAR (Ly-1 antibody reactive clone) as a key regulator of the migration and invasion of human CRC cells. Immunohistochemistry analysis demonstrated that LYAR is expressed at a higher level in metastatic CRC tissues. We found that LYAR promoted the migratory and invasive capabilities of CRC cells. Gene expression profile analysis of CRC cells showed that LGALS1, which encodes the galectin-1 protein, was a potential target of LYAR. The ChIP assay and gene reporter assays indicated that LYAR directly bound to the LGALS1 promoter. The ectopic expression of galectin-1 partially restored the mobile potential of LYAR knocked-down cells, which suggests that galectin-1 contributed to the LYAR-promoted cell migration and invasion of CRC cells. Thus, this study revealed a novel mechanism...
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titleLYAR promotes colorectal cancer cell mobility by activating galectin-1 expression.
authorWu, Yupeng ; Liu, Ming ; Li, Zhuchen ; Wu, Xiao-Bin ; Wang, Ying ; Wang, Yadong ; Nie, Min ; Huang, Feifei ; Ju, Junyi ; Ma, Chi ; Tan, Renxiang ; Zen, Ke ; Zhang, Chen-Yu ; Fu, Keqin ; Chen, Yu-Gen ; Wang, Ming-Rong ; Zhao, Quan
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