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Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial.

IMPORTANCEBreast cancer is the leading cause of female cancer burden, and its incidence has increased by more than 20% worldwide since 2008. Some observational studies have suggested that the Mediterranean diet may reduce the risk of breast cancer. OBJECTIVETo evaluate the effect of 2 interventions... Full description

Journal Title: JAMA internal medicine November 2015, Vol.175(11), pp.1752-1760
Main Author: Toledo, Estefanía
Other Authors: Salas-Salvadó, Jordi , Donat-Vargas, Carolina , Buil-Cosiales, Pilar , Estruch, Ramón , Ros, Emilio , Corella, Dolores , Fitó, Montserrat , Hu, Frank B , Arós, Fernando , Gómez-Gracia, Enrique , Romaguera, Dora , Ortega-Calvo, Manuel , Serra-Majem
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 2168-6114 ; DOI: 10.1001/jamainternmed.2015.4838
Link: http://search.proquest.com/docview/1730020714/?pq-origsite=primo
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title: Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial.
format: Article
creator:
  • Toledo, Estefanía
  • Salas-Salvadó, Jordi
  • Donat-Vargas, Carolina
  • Buil-Cosiales, Pilar
  • Estruch, Ramón
  • Ros, Emilio
  • Corella, Dolores
  • Fitó, Montserrat
  • Hu, Frank B
  • Arós, Fernando
  • Gómez-Gracia, Enrique
  • Romaguera, Dora
  • Ortega-Calvo, Manuel
  • Serra-Majem
subjects:
  • Aged–Diet Therapy
  • Breast Neoplasms–Epidemiology
  • Cardiovascular Diseases–Prevention & Control
  • Diet, Mediterranean–Epidemiology
  • Dietary Fats–Prevention & Control
  • Female–Psychology
  • Follow-Up Studies–Statistics & Numerical Data
  • Humans–Methods
  • Incidence–Statistics & Numerical Data
  • Middle Aged–Statistics & Numerical Data
  • Nuts–Statistics & Numerical Data
  • Olive Oil–Statistics & Numerical Data
  • Primary Prevention
ispartof: JAMA internal medicine, November 2015, Vol.175(11), pp.1752-1760
description: IMPORTANCEBreast cancer is the leading cause of female cancer burden, and its incidence has increased by more than 20% worldwide since 2008. Some observational studies have suggested that the Mediterranean diet may reduce the risk of breast cancer. OBJECTIVETo evaluate the effect of 2 interventions with Mediterranean diet vs the advice to follow a low-fat diet (control) on breast cancer incidence. DESIGN, SETTING, AND PARTICIPANTSThe PREDIMED study is a 1:1:1 randomized, single-blind, controlled field trial conducted at primary health care centers in Spain. From 2003 to 2009, 4282 women aged 60 to 80 years and at high cardiovascular disease risk were recruited after invitation by their primary care physicians. INTERVENTIONSParticipants were randomly allocated to a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat). MAIN OUTCOMES AND MEASURESBreast cancer incidence was a prespecified...
language: eng
source:
identifier: E-ISSN: 2168-6114 ; DOI: 10.1001/jamainternmed.2015.4838
fulltext: fulltext
issn:
  • 21686114
  • 2168-6114
url: Link


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titleMediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial.
creatorToledo, Estefanía ; Salas-Salvadó, Jordi ; Donat-Vargas, Carolina ; Buil-Cosiales, Pilar ; Estruch, Ramón ; Ros, Emilio ; Corella, Dolores ; Fitó, Montserrat ; Hu, Frank B ; Arós, Fernando ; Gómez-Gracia, Enrique ; Romaguera, Dora ; Ortega-Calvo, Manuel ; Serra-Majem
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identifierE-ISSN: 2168-6114 ; DOI: 10.1001/jamainternmed.2015.4838
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descriptionIMPORTANCEBreast cancer is the leading cause of female cancer burden, and its incidence has increased by more than 20% worldwide since 2008. Some observational studies have suggested that the Mediterranean diet may reduce the risk of breast cancer. OBJECTIVETo evaluate the effect of 2 interventions with Mediterranean diet vs the advice to follow a low-fat diet (control) on breast cancer incidence. DESIGN, SETTING, AND PARTICIPANTSThe PREDIMED study is a 1:1:1 randomized, single-blind, controlled field trial conducted at primary health care centers in Spain. From 2003 to 2009, 4282 women aged 60 to 80 years and at high cardiovascular disease risk were recruited after invitation by their primary care physicians. INTERVENTIONSParticipants were randomly allocated to a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat). MAIN OUTCOMES AND MEASURESBreast cancer incidence was a prespecified...
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titleMediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial.
descriptionIMPORTANCEBreast cancer is the leading cause of female cancer burden, and its incidence has increased by more than 20% worldwide since 2008. Some observational studies have suggested that the Mediterranean diet may reduce the risk of breast cancer. OBJECTIVETo evaluate the effect of 2 interventions with Mediterranean diet vs the advice to follow a low-fat diet (control) on breast cancer incidence. DESIGN, SETTING, AND PARTICIPANTSThe PREDIMED study is a 1:1:1 randomized, single-blind, controlled field trial conducted at primary health care centers in Spain. From 2003 to 2009, 4282 women aged 60 to 80 years and at high cardiovascular disease risk were recruited after invitation by their primary care physicians. INTERVENTIONSParticipants were randomly allocated to a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat). MAIN OUTCOMES AND MEASURESBreast cancer incidence was a prespecified...
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titleMediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial.
authorToledo, Estefanía ; Salas-Salvadó, Jordi ; Donat-Vargas, Carolina ; Buil-Cosiales, Pilar ; Estruch, Ramón ; Ros, Emilio ; Corella, Dolores ; Fitó, Montserrat ; Hu, Frank B ; Arós, Fernando ; Gómez-Gracia, Enrique ; Romaguera, Dora ; Ortega-Calvo, Manuel ; Serra-Majem
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abstractIMPORTANCEBreast cancer is the leading cause of female cancer burden, and its incidence has increased by more than 20% worldwide since 2008. Some observational studies have suggested that the Mediterranean diet may reduce the risk of breast cancer. OBJECTIVETo evaluate the effect of 2 interventions with Mediterranean diet vs the advice to follow a low-fat diet (control) on breast cancer incidence. DESIGN, SETTING, AND PARTICIPANTSThe PREDIMED study is a 1:1:1 randomized, single-blind, controlled field trial conducted at primary health care centers in Spain. From 2003 to 2009, 4282 women aged 60 to 80 years and at high cardiovascular disease risk were recruited after invitation by their primary care physicians. INTERVENTIONSParticipants were randomly allocated to a Mediterranean diet supplemented with extra-virgin olive oil, a Mediterranean diet supplemented with mixed nuts, or a control diet (advice to reduce dietary fat). MAIN OUTCOMES AND MEASURESBreast cancer incidence was a prespecified...
doi10.1001/jamainternmed.2015.4838
urlhttp://search.proquest.com/docview/1730020714/
issn21686106
date2015-11-01