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Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair

Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ~70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopaus... Full description

Journal Title: Nature Genetics Nov 2015, Vol.47(11), pp.1294-1303B
Main Author: Day, Felix
Other Authors: Ruth, Katherine , Thompson, Deborah , Lunetta, Kathryn , Pervjakova, Natalia , Chasman, Daniel , Stolk, Lisette , Finucane, Hilary , Sulem, Patrick , Bulik-Sullivan, Brendan , Hamann, Ute , Henderson, Brian , Hocking, Lynne , Hofman, Albert , Homuth, Georg , Hooning, Maartje , Hopper, John , Hu, Frank , Huang, Jinyan , Humphreys
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 10614036 ; E-ISSN: 15461718
Link: http://search.proquest.com/docview/1730676155/?pq-origsite=primo
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title: Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
format: Article
creator:
  • Day, Felix
  • Ruth, Katherine
  • Thompson, Deborah
  • Lunetta, Kathryn
  • Pervjakova, Natalia
  • Chasman, Daniel
  • Stolk, Lisette
  • Finucane, Hilary
  • Sulem, Patrick
  • Bulik-Sullivan, Brendan
  • Hamann, Ute
  • Henderson, Brian
  • Hocking, Lynne
  • Hofman, Albert
  • Homuth, Georg
  • Hooning, Maartje
  • Hopper, John
  • Hu, Frank
  • Huang, Jinyan
  • Humphreys
subjects:
  • Womens Health
  • Studies
  • Genealogy
  • Deoxyribonucleic Acid–DNA
  • Genomes
  • Consortia
  • Meta-Analysis
ispartof: Nature Genetics, Nov 2015, Vol.47(11), pp.1294-1303B
description: Menopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ~70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause...
language: eng
source:
identifier: ISSN: 10614036 ; E-ISSN: 15461718
fulltext: fulltext
issn:
  • 10614036
  • 1061-4036
  • 15461718
  • 1546-1718
url: Link


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titleLarge-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
creatorDay, Felix ; Ruth, Katherine ; Thompson, Deborah ; Lunetta, Kathryn ; Pervjakova, Natalia ; Chasman, Daniel ; Stolk, Lisette ; Finucane, Hilary ; Sulem, Patrick ; Bulik-Sullivan, Brendan ; Hamann, Ute ; Henderson, Brian ; Hocking, Lynne ; Hofman, Albert ; Homuth, Georg ; Hooning, Maartje ; Hopper, John ; Hu, Frank ; Huang, Jinyan ; Humphreys
ispartofNature Genetics, Nov 2015, Vol.47(11), pp.1294-1303B
identifierISSN: 10614036 ; E-ISSN: 15461718
subjectWomens Health ; Studies ; Genealogy ; Deoxyribonucleic Acid–DNA ; Genomes ; Consortia ; Meta-Analysis
descriptionMenopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ~70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause...
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titleLarge-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
authorDay, Felix ; Ruth, Katherine ; Thompson, Deborah ; Lunetta, Kathryn ; Pervjakova, Natalia ; Chasman, Daniel ; Stolk, Lisette ; Finucane, Hilary ; Sulem, Patrick ; Bulik-Sullivan, Brendan ; Hamann, Ute ; Henderson, Brian ; Hocking, Lynne ; Hofman, Albert ; Homuth, Georg ; Hooning, Maartje ; Hopper, John...
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56Nalls, Michael
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76Psaty, Bruce
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79Raffel, Leslie
80Rivadeneira, Fernando
81Rudan, Igor
82Rudolph, Anja
83Ruggiero, Daniela
84Sala, Cinzia
85Sanna, Serena
86Brody, Jennifer
87Sawyer, Elinor
88Schlessinger, David
89Schmidt, Marjanka
90Schmidt, Frank
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94Seynaeve, Caroline
95Simard, Jacques
96Sorice, Rossella
97Franke, Lude
98Southey, Melissa
99Stöckl, Doris
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atitleLarge-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
jtitleNature Genetics
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abstractMenopause timing has a substantial impact on infertility and risk of disease, including breast cancer, but the underlying mechanisms are poorly understood. We report a dual strategy in ~70,000 women to identify common and low-frequency protein-coding variation associated with age at natural menopause...
copNew York
pubNature Publishing Group
urlhttp://search.proquest.com/docview/1730676155/
doi10.1038/ng.3412
date2015-11-01