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Differential Regulation of Gene and Protein Expression by Zinc Oxide Nanoparticles in Hen's Ovarian Granulosa Cells: Specific Roles of Nanoparticles: e0140499

Annually, tons and tons of zinc oxide nanoparticles (ZnO NPs) are produced in the world. And they are applied in almost all aspects of our life. Their release from the products into environment may pose issue for human health. Although many studies have reported the adverse effects of ZnO NPs on org... Full description

Journal Title: PLoS ONE Oct 2015, Vol.10(10)
Main Author: Zhao, Yong
Other Authors: Li, Lan , Zhang, Peng-Fei , Shen, Wei , Liu, Jing , Yang, Fen-Fang , Liu, Hong-Bo , Hao, Zhi-Hui
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0140499
Link: http://search.proquest.com/docview/1732806823/?pq-origsite=primo
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title: Differential Regulation of Gene and Protein Expression by Zinc Oxide Nanoparticles in Hen's Ovarian Granulosa Cells: Specific Roles of Nanoparticles: e0140499
format: Article
creator:
  • Zhao, Yong
  • Li, Lan
  • Zhang, Peng-Fei
  • Shen, Wei
  • Liu, Jing
  • Yang, Fen-Fang
  • Liu, Hong-Bo
  • Hao, Zhi-Hui
subjects:
  • Zinc Oxide -- Research
  • Nanoparticles -- Research
  • Nanoparticles -- Physiological Aspects
  • Gene Expression -- Research
ispartof: PLoS ONE, Oct 2015, Vol.10(10)
description: Annually, tons and tons of zinc oxide nanoparticles (ZnO NPs) are produced in the world. And they are applied in almost all aspects of our life. Their release from the products into environment may pose issue for human health. Although many studies have reported the adverse effects of ZnO NPs on organisms, little is known about the effects on female reproductive systems or the related mechanisms. Quantitative proteomics have not been applied although quantitative transcriptomics have been used in zinc oxide nanoparticles (ZnO NPs) research. Genes are very important players however proteins are the real actors in the biological systems. By using hen's ovarian granulosa cells, it was found that ZnO-NP-5Mg/ml and ZnSO4-10Mg/ml treatments produced the same amount of intracellular Zn and resulted in similar cell growth inhibition. And NPs were found in the treated cells. However, ZnO-NP-5Mg/ml specifically regulated the expression of genes and proteins compared with...
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0140499
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleDifferential Regulation of Gene and Protein Expression by Zinc Oxide Nanoparticles in Hen's Ovarian Granulosa Cells: Specific Roles of Nanoparticles: e0140499
creatorZhao, Yong ; Li, Lan ; Zhang, Peng-Fei ; Shen, Wei ; Liu, Jing ; Yang, Fen-Fang ; Liu, Hong-Bo ; Hao, Zhi-Hui
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identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0140499
descriptionAnnually, tons and tons of zinc oxide nanoparticles (ZnO NPs) are produced in the world. And they are applied in almost all aspects of our life. Their release from the products into environment may pose issue for human health. Although many studies have reported the adverse effects of ZnO NPs on organisms, little is known about the effects on female reproductive systems or the related mechanisms. Quantitative proteomics have not been applied although quantitative transcriptomics have been used in zinc oxide nanoparticles (ZnO NPs) research. Genes are very important players however proteins are the real actors in the biological systems. By using hen's ovarian granulosa cells, it was found that ZnO-NP-5Mg/ml and ZnSO4-10Mg/ml treatments produced the same amount of intracellular Zn and resulted in similar cell growth inhibition. And NPs were found in the treated cells. However, ZnO-NP-5Mg/ml specifically regulated the expression of genes and proteins compared with...
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titleDifferential Regulation of Gene and Protein Expression by Zinc Oxide Nanoparticles in Hen's Ovarian Granulosa Cells: Specific Roles of Nanoparticles: e0140499
descriptionAnnually, tons and tons of zinc oxide nanoparticles (ZnO NPs) are produced in the world. And they are applied in almost all aspects of our life. Their release from the products into environment may pose issue for human health. Although many studies have reported the adverse effects of ZnO NPs on organisms, little is known about the effects on female reproductive systems or the related mechanisms. Quantitative proteomics have not been applied although quantitative transcriptomics have been used in zinc oxide nanoparticles (ZnO NPs) research. Genes are very important players however proteins are the real actors in the biological systems. By using hen's ovarian granulosa cells, it was found that ZnO-NP-5Mg/ml and ZnSO4-10Mg/ml treatments produced the same amount of intracellular Zn and resulted in similar cell growth inhibition. And NPs were found in the treated cells. However, ZnO-NP-5Mg/ml specifically regulated the expression of genes and proteins compared with...
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abstractAnnually, tons and tons of zinc oxide nanoparticles (ZnO NPs) are produced in the world. And they are applied in almost all aspects of our life. Their release from the products into environment may pose issue for human health. Although many studies have reported the adverse effects of ZnO NPs on organisms, little is known about the effects on female reproductive systems or the related mechanisms. Quantitative proteomics have not been applied although quantitative transcriptomics have been used in zinc oxide nanoparticles (ZnO NPs) research. Genes are very important players however proteins are the real actors in the biological systems. By using hen's ovarian granulosa cells, it was found that ZnO-NP-5Mg/ml and ZnSO4-10Mg/ml treatments produced the same amount of intracellular Zn and resulted in similar cell growth inhibition. And NPs were found in the treated cells. However, ZnO-NP-5Mg/ml specifically regulated the expression of genes and proteins compared with...
doi10.1371/journal.pone.0140499
urlhttp://search.proquest.com/docview/1732806823/
pagese0140499
date2015-10-01