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Suppression of Inflammatory Mediators by the Ethanol Extract of Crotalaria verrucosa L. leaf - in vivo and in vitro Analysis

  Objective: The present study demonstrated the potential of Crotalaria verrucosa L., a widely used medicinal plant of Bangladesh, ethanolic leaf extract in inhibiting the cascades of inflammation. Methods: Carrageenan induced rat paw edema and xylene induced mice ear edema tests were performed as i... Full description

Journal Title: European Journal of Medicinal Plants 2016, Vol.11(3)
Main Author: Nawrin, Kashfia
Other Authors: Billah, Mohammad , Jabed, Mohammed , Khalil, Mohammad , Uddin, Md. , Islam, Md.,
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 22310894
Link: http://search.proquest.com/docview/1733141983/?pq-origsite=primo
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title: Suppression of Inflammatory Mediators by the Ethanol Extract of Crotalaria verrucosa L. leaf - in vivo and in vitro Analysis
format: Article
creator:
  • Nawrin, Kashfia
  • Billah, Mohammad
  • Jabed, Mohammed
  • Khalil, Mohammad
  • Uddin, Md.
  • Islam, Md.
subjects:
  • Inflammation
  • Herbal Medicine
  • Phytochemicals
  • Flowers & Plants
ispartof: European Journal of Medicinal Plants, 2016, Vol.11(3)
description:   Objective: The present study demonstrated the potential of Crotalaria verrucosa L., a widely used medicinal plant of Bangladesh, ethanolic leaf extract in inhibiting the cascades of inflammation. Methods: Carrageenan induced rat paw edema and xylene induced mice ear edema tests were performed as in vivo assessment of anti-inflammatory activity. Moreover, these methods were supported by the in vitro heat induced protein denaturation and haemolysis tests. Results: In all experiments CVE extract shows moderate to significant efficacy. CVE 600 mg/kg significantly suppressed the biological response (edema) in comparison to both steroidal and non-steroidal anti-inflammatory drugs. Moreover in vitro study suggested that the leaf extract at doses of 300, 400 and 500 µg/ml possess moderate to high inhibition capacity for auto antigen production which exerts extract's potential against Type III hypersensitivity. Conclusion: All these data support the safe use of this plant traditionally. However, the extract is yet to be explored for responsible compounds and specific mechanisms.
language: eng
source:
identifier: E-ISSN: 22310894
fulltext: no_fulltext
issn:
  • 22310894
  • 2231-0894
url: Link


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titleSuppression of Inflammatory Mediators by the Ethanol Extract of Crotalaria verrucosa L. leaf - in vivo and in vitro Analysis
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identifierE-ISSN: 22310894
subjectInflammation ; Herbal Medicine ; Phytochemicals ; Flowers & Plants
description  Objective: The present study demonstrated the potential of Crotalaria verrucosa L., a widely used medicinal plant of Bangladesh, ethanolic leaf extract in inhibiting the cascades of inflammation. Methods: Carrageenan induced rat paw edema and xylene induced mice ear edema tests were performed as in vivo assessment of anti-inflammatory activity. Moreover, these methods were supported by the in vitro heat induced protein denaturation and haemolysis tests. Results: In all experiments CVE extract shows moderate to significant efficacy. CVE 600 mg/kg significantly suppressed the biological response (edema) in comparison to both steroidal and non-steroidal anti-inflammatory drugs. Moreover in vitro study suggested that the leaf extract at doses of 300, 400 and 500 µg/ml possess moderate to high inhibition capacity for auto antigen production which exerts extract's potential against Type III hypersensitivity. Conclusion: All these data support the safe use of this plant traditionally. However, the extract is yet to be explored for responsible compounds and specific mechanisms.
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titleSuppression of Inflammatory Mediators by the Ethanol Extract of Crotalaria verrucosa L. leaf - in vivo and in vitro Analysis
description  Objective: The present study demonstrated the potential of Crotalaria verrucosa L., a widely used medicinal plant of Bangladesh, ethanolic leaf extract in inhibiting the cascades of inflammation. Methods: Carrageenan induced rat paw edema and xylene induced mice ear edema tests were performed as in vivo assessment of anti-inflammatory activity. Moreover, these methods were supported by the in vitro heat induced protein denaturation and haemolysis tests. Results: In all experiments CVE extract shows moderate to significant efficacy. CVE 600 mg/kg significantly suppressed the biological response (edema) in comparison to both steroidal and non-steroidal anti-inflammatory drugs. Moreover in vitro study suggested that the leaf extract at doses of 300, 400 and 500 µg/ml possess moderate to high inhibition capacity for auto antigen production which exerts extract's potential against Type III hypersensitivity. Conclusion: All these data support the safe use of this plant traditionally. However, the extract is yet to be explored for responsible compounds and specific mechanisms.
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titleSuppression of Inflammatory Mediators by the Ethanol Extract of Crotalaria verrucosa L. leaf - in vivo and in vitro Analysis
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abstract  Objective: The present study demonstrated the potential of Crotalaria verrucosa L., a widely used medicinal plant of Bangladesh, ethanolic leaf extract in inhibiting the cascades of inflammation. Methods: Carrageenan induced rat paw edema and xylene induced mice ear edema tests were performed as in vivo assessment of anti-inflammatory activity. Moreover, these methods were supported by the in vitro heat induced protein denaturation and haemolysis tests. Results: In all experiments CVE extract shows moderate to significant efficacy. CVE 600 mg/kg significantly suppressed the biological response (edema) in comparison to both steroidal and non-steroidal anti-inflammatory drugs. Moreover in vitro study suggested that the leaf extract at doses of 300, 400 and 500 µg/ml possess moderate to high inhibition capacity for auto antigen production which exerts extract's potential against Type III hypersensitivity. Conclusion: All these data support the safe use of this plant traditionally. However, the extract is yet to be explored for responsible compounds and specific mechanisms.
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pubSCIENCEDOMAIN International
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doi10.9734/EJMP/2016/21894
issnEuropean Journal of Medicinal Plants
date2016-01-01