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Vascular autorescaling of fMRI (VasA fMRI) improves sensitivity of population studies: A pilot study.

The blood oxygenation level-dependent (BOLD) signal is widely used for functional magnetic resonance imaging (fMRI) of brain function in health and disease. The statistical power of fMRI group studies is significantly hampered by high inter-subject variance due to differences in baseline vascular ph... Full description

Journal Title: NeuroImage January 1, 2016, Vol.124, pp.794-805
Main Author: Kazan, Samira M
Other Authors: Mohammadi, Siawoosh , Callaghan, Martina F , Flandin, Guillaume , Huber, Laurentius , Leech, Robert , Kennerley, Aneurin , Windischberger, Christian , Weiskopf, Nikolaus
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1095-9572 ; DOI: 10.1016/j.neuroimage.2015.09.033
Link: http://search.proquest.com/docview/1735906483/?pq-origsite=primo
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title: Vascular autorescaling of fMRI (VasA fMRI) improves sensitivity of population studies: A pilot study.
format: Article
creator:
  • Kazan, Samira M
  • Mohammadi, Siawoosh
  • Callaghan, Martina F
  • Flandin, Guillaume
  • Huber, Laurentius
  • Leech, Robert
  • Kennerley, Aneurin
  • Windischberger, Christian
  • Weiskopf, Nikolaus
subjects:
  • Algorithms–Blood
  • Brain Mapping–Physiology
  • Carbon Dioxide–Pathology
  • Cerebrovascular Circulation–Methods
  • False Positive Reactions–Methods
  • Female–Blood
  • Healthy Volunteers–Blood Supply
  • Humans–Physiology
  • Hypercapnia–Blood Supply
  • Image Processing, Computer-Assisted–Blood Supply
  • Magnetic Resonance Imaging–Blood Supply
  • Male–Blood Supply
  • Oxygen–Blood Supply
  • Pilot Projects–Blood Supply
  • Prefrontal Cortex–Blood Supply
  • Respiratory Mechanics–Blood Supply
  • Visual Cortex–Blood Supply
  • Young Adult–Blood Supply
  • Carbon Dioxide
  • Oxygen
  • Alff
  • Autorescaling
  • Bold Fmri
  • Group Analysis
  • Vascularization Differences
ispartof: NeuroImage, January 1, 2016, Vol.124, pp.794-805
description: The blood oxygenation level-dependent (BOLD) signal is widely used for functional magnetic resonance imaging (fMRI) of brain function in health and disease. The statistical power of fMRI group studies is significantly hampered by high inter-subject variance due to differences in baseline vascular physiology. Several methods have been proposed to account for physiological vascularization differences between subjects and hence improve the sensitivity in group studies. However, these methods require the acquisition of additional reference scans (such as a full resting-state fMRI session or ASL-based calibrated BOLD). We present a vascular autorescaling (VasA) method, which does not require any additional reference scans. VasA is based on the observation that slow oscillations (
language: eng
source:
identifier: E-ISSN: 1095-9572 ; DOI: 10.1016/j.neuroimage.2015.09.033
fulltext: fulltext
issn:
  • 10959572
  • 1095-9572
url: Link


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titleVascular autorescaling of fMRI (VasA fMRI) improves sensitivity of population studies: A pilot study.
creatorKazan, Samira M ; Mohammadi, Siawoosh ; Callaghan, Martina F ; Flandin, Guillaume ; Huber, Laurentius ; Leech, Robert ; Kennerley, Aneurin ; Windischberger, Christian ; Weiskopf, Nikolaus
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ispartofNeuroImage, January 1, 2016, Vol.124, pp.794-805
identifierE-ISSN: 1095-9572 ; DOI: 10.1016/j.neuroimage.2015.09.033
subjectAlgorithms–Blood ; Brain Mapping–Physiology ; Carbon Dioxide–Pathology ; Cerebrovascular Circulation–Methods ; False Positive Reactions–Methods ; Female–Blood ; Healthy Volunteers–Blood Supply ; Humans–Physiology ; Hypercapnia–Blood Supply ; Image Processing, Computer-Assisted–Blood Supply ; Magnetic Resonance Imaging–Blood Supply ; Male–Blood Supply ; Oxygen–Blood Supply ; Pilot Projects–Blood Supply ; Prefrontal Cortex–Blood Supply ; Respiratory Mechanics–Blood Supply ; Visual Cortex–Blood Supply ; Young Adult–Blood Supply ; Carbon Dioxide ; Oxygen ; Alff ; Autorescaling ; Bold Fmri ; Group Analysis ; Vascularization Differences
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descriptionThe blood oxygenation level-dependent (BOLD) signal is widely used for functional magnetic resonance imaging (fMRI) of brain function in health and disease. The statistical power of fMRI group studies is significantly hampered by high inter-subject variance due to differences in baseline vascular physiology. Several methods have been proposed to account for physiological vascularization differences between subjects and hence improve the sensitivity in group studies. However, these methods require the acquisition of additional reference scans (such as a full resting-state fMRI session or ASL-based calibrated BOLD). We present a vascular autorescaling (VasA) method, which does not require any additional reference scans. VasA is based on the observation that slow oscillations (<0.1Hz) in arterial blood CO2 levels occur naturally due to changes in respiration patterns. These oscillations yield fMRI signal changes whose amplitudes reflect the blood oxygenation levels and underlying local vascularization and vascular responsivity. VasA estimates proxies of the amplitude of these CO2-driven oscillations directly from the residuals of task-related fMRI data without the need for reference scans. The estimates are used to scale the amplitude of task-related fMRI responses, to account for vascular differences. The VasA maps compared well to cerebrovascular reactivity (CVR) maps and cerebral blood volume maps based on vascular space occupancy (VASO) measurements in four volunteers, speaking to the physiological vascular basis of VasA. VasA was validated in a wide variety of tasks in 138 volunteers. VasA increased t-scores by up to 30% in specific brain areas such as the visual cortex. The number of activated voxels was increased by up to 200% in brain areas such as the orbital frontal cortex while still controlling the nominal false-positive rate. VasA fMRI outperformed previously proposed rescaling approaches based on resting-state fMRI data and can be readily applied to any task-related fMRI data set, even retrospectively. •We present a vascular autocalibration method (VasA) for fMRI studies.•VasA fMRI accounts for physiological vascularization differences between subjects.•VasA fMRI significantly increases functional sensitivity in group analyses.•VasA does not require additional reference scans or other complicated procedures.•VasA can be readily applied to any task-related fMRI data set, even retrospectively.
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7Windischberger, Christian
8Weiskopf, Nikolaus
titleVascular autorescaling of fMRI (VasA fMRI) improves sensitivity of population studies: A pilot study.
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titleVascular autorescaling of fMRI (VasA fMRI) improves sensitivity of population studies: A pilot study.
authorKazan, Samira M ; Mohammadi, Siawoosh ; Callaghan, Martina F ; Flandin, Guillaume ; Huber, Laurentius ; Leech, Robert ; Kennerley, Aneurin ; Windischberger, Christian ; Weiskopf, Nikolaus
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