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Processing of frequency and location in human subcortical auditory structures.

To date it remains largely unknown how fundamental aspects of natural sounds, such as their spectral content and location in space, are processed in human subcortical structures. Here we exploited the high sensitivity and specificity of high field fMRI (7 Tesla) to examine the human inferior collicu... Full description

Journal Title: Scientific reports November 24, 2015, Vol.5, p.17048
Main Author: Moerel, Michelle
Other Authors: De Martino, Federico , Uğurbil, Kâmil , Yacoub, Essa , Formisano, Elia
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 2045-2322 ; DOI: 10.1038/srep17048
Link: http://search.proquest.com/docview/1736415699/?pq-origsite=primo
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title: Processing of frequency and location in human subcortical auditory structures.
format: Article
creator:
  • Moerel, Michelle
  • De Martino, Federico
  • Uğurbil, Kâmil
  • Yacoub, Essa
  • Formisano, Elia
subjects:
  • Acoustic Stimulation–Physiology
  • Adult–Physiology
  • Auditory Cortex–Physiology
  • Auditory Perception–Physiology
  • Female–Physiology
  • Humans–Physiology
  • Magnetic Resonance Imaging–Physiology
  • Male–Physiology
  • Sensitivity and Specificity–Physiology
  • Young Adult–Physiology
ispartof: Scientific reports, November 24, 2015, Vol.5, p.17048
description: To date it remains largely unknown how fundamental aspects of natural sounds, such as their spectral content and location in space, are processed in human subcortical structures. Here we exploited the high sensitivity and specificity of high field fMRI (7 Tesla) to examine the human inferior colliculus (IC) and medial geniculate body (MGB). Subcortical responses to natural sounds were well explained by an encoding model of sound processing that represented frequency and location jointly. Frequency tuning was organized in one tonotopic gradient in the IC, whereas two tonotopic maps characterized the MGB reflecting two MGB subdivisions. In contrast, no topographic pattern of preferred location was detected, beyond an overall preference for peripheral (as opposed to central) and contralateral locations. Our findings suggest the functional organization of frequency and location processing in human subcortical auditory structures, and pave the way for studying the subcortical to cortical interaction required to create coherent auditory percepts.
language: eng
source:
identifier: E-ISSN: 2045-2322 ; DOI: 10.1038/srep17048
fulltext: fulltext
issn:
  • 20452322
  • 2045-2322
url: Link


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titleProcessing of frequency and location in human subcortical auditory structures.
creatorMoerel, Michelle ; De Martino, Federico ; Uğurbil, Kâmil ; Yacoub, Essa ; Formisano, Elia
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identifierE-ISSN: 2045-2322 ; DOI: 10.1038/srep17048
subjectAcoustic Stimulation–Physiology ; Adult–Physiology ; Auditory Cortex–Physiology ; Auditory Perception–Physiology ; Female–Physiology ; Humans–Physiology ; Magnetic Resonance Imaging–Physiology ; Male–Physiology ; Sensitivity and Specificity–Physiology ; Young Adult–Physiology
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descriptionTo date it remains largely unknown how fundamental aspects of natural sounds, such as their spectral content and location in space, are processed in human subcortical structures. Here we exploited the high sensitivity and specificity of high field fMRI (7 Tesla) to examine the human inferior colliculus (IC) and medial geniculate body (MGB). Subcortical responses to natural sounds were well explained by an encoding model of sound processing that represented frequency and location jointly. Frequency tuning was organized in one tonotopic gradient in the IC, whereas two tonotopic maps characterized the MGB reflecting two MGB subdivisions. In contrast, no topographic pattern of preferred location was detected, beyond an overall preference for peripheral (as opposed to central) and contralateral locations. Our findings suggest the functional organization of frequency and location processing in human subcortical auditory structures, and pave the way for studying the subcortical to cortical interaction required to create coherent auditory percepts.
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