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miR-149 represses metastasis of hepatocellular carcinoma by targeting actin-regulatory proteins PPM1F.

microRNAs have been implicated in hepatocellular carcinoma (HCC) metastasis, which is predominant cause of high mortality in these patients. Although an increasing body of evidence indicates that miR-149 plays an important role in the growth and metastasis of multiple types of cancers, its role in t... Full description

Journal Title: Oncotarget November 10, 2015, Vol.6(35), pp.37808-37823
Main Author: Luo, Gang
Other Authors: Chao, Ya-Ling , Tang, Bo , Li, Bo-Sheng , Xiao, Yu-Feng , Xie, Rui , Wang, Shu-Ming , Wu, Yu-Yun , Dong, Hui , Liu, Xiang D , Yang, Shi-Ming
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.5676
Link: http://search.proquest.com/docview/1737478401/?pq-origsite=primo
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title: miR-149 represses metastasis of hepatocellular carcinoma by targeting actin-regulatory proteins PPM1F.
format: Article
creator:
  • Luo, Gang
  • Chao, Ya-Ling
  • Tang, Bo
  • Li, Bo-Sheng
  • Xiao, Yu-Feng
  • Xie, Rui
  • Wang, Shu-Ming
  • Wu, Yu-Yun
  • Dong, Hui
  • Liu, Xiang D
  • Yang, Shi-Ming
subjects:
  • Animals–Genetics
  • Apoptosis–Metabolism
  • Biomarkers, Tumor–Genetics
  • Blotting, Western–Mortality
  • Carcinoma, Hepatocellular–Prevention & Control
  • Cell Movement–Secondary
  • Cell Proliferation–Genetics
  • Female–Mortality
  • Fluorescent Antibody Technique–Pathology
  • Follow-Up Studies–Prevention & Control
  • Gene Expression Regulation, Neoplastic–Genetics
  • Humans–Antagonists & Inhibitors
  • Immunoenzyme Techniques–Genetics
  • In Situ Hybridization, Fluorescence–Metabolism
  • Liver Neoplasms–Genetics
  • Lymphatic Metastasis–Genetics
  • Male–Genetics
  • Mice–Genetics
  • Mice, Inbred Balb C–Genetics
  • Mice, Nude–Genetics
  • Micrornas–Genetics
  • Middle Aged–Genetics
  • Neoplasm Grading–Genetics
  • Neoplasm Invasiveness–Genetics
  • Neoplasm Staging–Genetics
  • Phosphoprotein Phosphatases–Genetics
  • Prognosis–Genetics
  • RNA, Messenger–Genetics
  • Real-Time Polymerase Chain Reaction–Genetics
  • Reverse Transcriptase Polymerase Chain Reaction–Genetics
  • Survival Rate–Genetics
  • Tumor Cells, Cultured–Genetics
  • Wound Healing–Genetics
  • Xenograft Model Antitumor Assays–Genetics
  • Biomarkers, Tumor
  • Mirn149 Microrna, Human
  • Micrornas
  • RNA, Messenger
  • Ppm1f Protein, Human
  • Phosphoprotein Phosphatases
  • Ppm1f
  • Hepatocellular Carcinoma
  • Metastasis
  • Mir-149
  • Microrna
ispartof: Oncotarget, November 10, 2015, Vol.6(35), pp.37808-37823
description: microRNAs have been implicated in hepatocellular carcinoma (HCC) metastasis, which is predominant cause of high mortality in these patients. Although an increasing body of evidence indicates that miR-149 plays an important role in the growth and metastasis of multiple types of cancers, its role in the progression of HCC remains unknown. Here, we demonstrated that miR-149 was significantly down-regulated in HCC, which was correlated with distant metastasis and TNM stage with statistical significance. A survival analysis showed that decreased miR-149 expression was correlated with a poor prognosis of HCC as well. We found that over-expression of miR-149 suppressed migration and invasion of HCC cells in vitro. In addition, we identified PPM1F (protein phosphatase, Mg(2+)/Mn(2+)-dependent, 1F) as a direct target of miR-149 whose expression was negatively correlated with the expression of miR-149 in HCC tissues. The re-expression of PPM1F rescued the miR-149-mediated inhibition of cell migration...
language: eng
source:
identifier: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.5676
fulltext: fulltext
issn:
  • 19492553
  • 1949-2553
url: Link


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titlemiR-149 represses metastasis of hepatocellular carcinoma by targeting actin-regulatory proteins PPM1F.
creatorLuo, Gang ; Chao, Ya-Ling ; Tang, Bo ; Li, Bo-Sheng ; Xiao, Yu-Feng ; Xie, Rui ; Wang, Shu-Ming ; Wu, Yu-Yun ; Dong, Hui ; Liu, Xiang D ; Yang, Shi-Ming
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ispartofOncotarget, November 10, 2015, Vol.6(35), pp.37808-37823
identifierE-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.5676
subjectAnimals–Genetics ; Apoptosis–Metabolism ; Biomarkers, Tumor–Genetics ; Blotting, Western–Mortality ; Carcinoma, Hepatocellular–Prevention & Control ; Cell Movement–Secondary ; Cell Proliferation–Genetics ; Female–Mortality ; Fluorescent Antibody Technique–Pathology ; Follow-Up Studies–Prevention & Control ; Gene Expression Regulation, Neoplastic–Genetics ; Humans–Antagonists & Inhibitors ; Immunoenzyme Techniques–Genetics ; In Situ Hybridization, Fluorescence–Metabolism ; Liver Neoplasms–Genetics ; Lymphatic Metastasis–Genetics ; Male–Genetics ; Mice–Genetics ; Mice, Inbred Balb C–Genetics ; Mice, Nude–Genetics ; Micrornas–Genetics ; Middle Aged–Genetics ; Neoplasm Grading–Genetics ; Neoplasm Invasiveness–Genetics ; Neoplasm Staging–Genetics ; Phosphoprotein Phosphatases–Genetics ; Prognosis–Genetics ; RNA, Messenger–Genetics ; Real-Time Polymerase Chain Reaction–Genetics ; Reverse Transcriptase Polymerase Chain Reaction–Genetics ; Survival Rate–Genetics ; Tumor Cells, Cultured–Genetics ; Wound Healing–Genetics ; Xenograft Model Antitumor Assays–Genetics ; Biomarkers, Tumor ; Mirn149 Microrna, Human ; Micrornas ; RNA, Messenger ; Ppm1f Protein, Human ; Phosphoprotein Phosphatases ; Ppm1f ; Hepatocellular Carcinoma ; Metastasis ; Mir-149 ; Microrna
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descriptionmicroRNAs have been implicated in hepatocellular carcinoma (HCC) metastasis, which is predominant cause of high mortality in these patients. Although an increasing body of evidence indicates that miR-149 plays an important role in the growth and metastasis of multiple types of cancers, its role in the progression of HCC remains unknown. Here, we demonstrated that miR-149 was significantly down-regulated in HCC, which was correlated with distant metastasis and TNM stage with statistical significance. A survival analysis showed that decreased miR-149 expression was correlated with a poor prognosis of HCC as well. We found that over-expression of miR-149 suppressed migration and invasion of HCC cells in vitro. In addition, we identified PPM1F (protein phosphatase, Mg(2+)/Mn(2+)-dependent, 1F) as a direct target of miR-149 whose expression was negatively correlated with the expression of miR-149 in HCC tissues. The re-expression of PPM1F rescued the miR-149-mediated inhibition of cell migration...
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titlemiR-149 represses metastasis of hepatocellular carcinoma by targeting actin-regulatory proteins PPM1F.
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0Animals–Genetics
1Apoptosis–Metabolism
2Biomarkers, Tumor–Genetics
3Blotting, Western–Mortality
4Carcinoma, Hepatocellular–Prevention & Control
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6Cell Proliferation–Genetics
7Female–Mortality
8Fluorescent Antibody Technique–Pathology
9Follow-Up Studies–Prevention & Control
10Gene Expression Regulation, Neoplastic–Genetics
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12Immunoenzyme Techniques–Genetics
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15Lymphatic Metastasis–Genetics
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titlemiR-149 represses metastasis of hepatocellular carcinoma by targeting actin-regulatory proteins PPM1F.
authorLuo, Gang ; Chao, Ya-Ling ; Tang, Bo ; Li, Bo-Sheng ; Xiao, Yu-Feng ; Xie, Rui ; Wang, Shu-Ming ; Wu, Yu-Yun ; Dong, Hui ; Liu, Xiang D ; Yang, Shi-Ming
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3Blotting, Western–Mortality
4Carcinoma, Hepatocellular–Prevention & Control
5Cell Movement–Secondary
6Cell Proliferation–Genetics
7Female–Mortality
8Fluorescent Antibody Technique–Pathology
9Follow-Up Studies–Prevention & Control
10Gene Expression Regulation, Neoplastic–Genetics
11Humans–Antagonists & Inhibitors
12Immunoenzyme Techniques–Genetics
13In Situ Hybridization, Fluorescence–Metabolism
14Liver Neoplasms–Genetics
15Lymphatic Metastasis–Genetics
16Male–Genetics
17Mice–Genetics
18Mice, Inbred Balb C–Genetics
19Mice, Nude–Genetics
20Micrornas–Genetics
21Middle Aged–Genetics
22Neoplasm Grading–Genetics
23Neoplasm Invasiveness–Genetics
24Neoplasm Staging–Genetics
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27RNA, Messenger–Genetics
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30Survival Rate–Genetics
31Tumor Cells, Cultured–Genetics
32Wound Healing–Genetics
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date2015-11-10