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The diagnostic and prognostic value of MRP8/MRP14 in intrahepatic cholangiocarcinoma.

Myeloid-related protein 8 (MRP8) and 14 (MRP14) are abundantly expressed in several kinds of benign and malignant tumors. However, little is known about their clinicopathological significance in intrahepatic cholangiocarcinoma (ICC), biliary intraepithelial neoplasia (BilIN), intraductal papillary n... Full description

Journal Title: Oncotarget November 17, 2015, Vol.6(36), pp.39357-39364
Main Author: Jin, Guang-Zhi
Other Authors: Dong, Wei , Dong, Hui , Yu, Hua , Chen, Jia , Yu, Wen-Long , Li, Ai-Jun , Cong, Wen-Ming , Wu, Meng-Chao
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.5329
Link: http://search.proquest.com/docview/1738817959/?pq-origsite=primo
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title: The diagnostic and prognostic value of MRP8/MRP14 in intrahepatic cholangiocarcinoma.
format: Article
creator:
  • Jin, Guang-Zhi
  • Dong, Wei
  • Dong, Hui
  • Yu, Hua
  • Chen, Jia
  • Yu, Wen-Long
  • Li, Ai-Jun
  • Cong, Wen-Ming
  • Wu, Meng-Chao
subjects:
  • ATP-Binding Cassette Transporters–Biosynthesis
  • Bile Duct Neoplasms–Diagnosis
  • Calgranulin B–Drug Therapy
  • Cholangiocarcinoma–Metabolism
  • Female–Pathology
  • Humans–Biosynthesis
  • Immunohistochemistry–Diagnosis
  • Male–Metabolism
  • Middle Aged–Pathology
  • Prognosis–Pathology
  • Tissue Array Analysis–Pathology
  • Abcc11 Protein, Human
  • ATP-Binding Cassette Transporters
  • Calgranulin B
  • Intrahepatic Cholangiocarcinoma
  • Myeloid-Related Protein 14
  • Myeloid-Related Protein 8
  • Prognosis
  • Tumor-Infiltrating Immune Cell
ispartof: Oncotarget, November 17, 2015, Vol.6(36), pp.39357-39364
description: Myeloid-related protein 8 (MRP8) and 14 (MRP14) are abundantly expressed in several kinds of benign and malignant tumors. However, little is known about their clinicopathological significance in intrahepatic cholangiocarcinoma (ICC), biliary intraepithelial neoplasia (BilIN), intraductal papillary neoplasm of bile duct (IPNB), or inflammatory hepatic biliary ducts epithelium (IHBD). This study aimed to investigate the diagnostic and prognostic values of MRP8 and MRP14 as new biomarkers for ICC. We examined MRP8 and MRP14 expression levels by immunohistochemistry in IHBD (n = 15), BilIN (BilIN1 = 24, BilIN2 = 9, BilIN3 = 5), IPNB (n = 18) and ICC (n = 416). The differential diagnostic and prognosis values were also evaluated. The results showed that the ratio of tumor-infiltrating MRP8 and MRP14 positive immune cells, relative to biliary epithelial cells, was significantly increased in ICC tissues compared with nonmalignant tissues, including IHBD, BilIN1, BilIN2, BilIN3, and IPNB (P value...
language: eng
source:
identifier: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.5329
fulltext: fulltext
issn:
  • 19492553
  • 1949-2553
url: Link


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titleThe diagnostic and prognostic value of MRP8/MRP14 in intrahepatic cholangiocarcinoma.
creatorJin, Guang-Zhi ; Dong, Wei ; Dong, Hui ; Yu, Hua ; Chen, Jia ; Yu, Wen-Long ; Li, Ai-Jun ; Cong, Wen-Ming ; Wu, Meng-Chao
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ispartofOncotarget, November 17, 2015, Vol.6(36), pp.39357-39364
identifierE-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.5329
subjectATP-Binding Cassette Transporters–Biosynthesis ; Bile Duct Neoplasms–Diagnosis ; Calgranulin B–Drug Therapy ; Cholangiocarcinoma–Metabolism ; Female–Pathology ; Humans–Biosynthesis ; Immunohistochemistry–Diagnosis ; Male–Metabolism ; Middle Aged–Pathology ; Prognosis–Pathology ; Tissue Array Analysis–Pathology ; Abcc11 Protein, Human ; ATP-Binding Cassette Transporters ; Calgranulin B ; Intrahepatic Cholangiocarcinoma ; Myeloid-Related Protein 14 ; Myeloid-Related Protein 8 ; Prognosis ; Tumor-Infiltrating Immune Cell
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descriptionMyeloid-related protein 8 (MRP8) and 14 (MRP14) are abundantly expressed in several kinds of benign and malignant tumors. However, little is known about their clinicopathological significance in intrahepatic cholangiocarcinoma (ICC), biliary intraepithelial neoplasia (BilIN), intraductal papillary neoplasm of bile duct (IPNB), or inflammatory hepatic biliary ducts epithelium (IHBD). This study aimed to investigate the diagnostic and prognostic values of MRP8 and MRP14 as new biomarkers for ICC. We examined MRP8 and MRP14 expression levels by immunohistochemistry in IHBD (n = 15), BilIN (BilIN1 = 24, BilIN2 = 9, BilIN3 = 5), IPNB (n = 18) and ICC (n = 416). The differential diagnostic and prognosis values were also evaluated. The results showed that the ratio of tumor-infiltrating MRP8 and MRP14 positive immune cells, relative to biliary epithelial cells, was significantly increased in ICC tissues compared with nonmalignant tissues, including IHBD, BilIN1, BilIN2, BilIN3, and IPNB (P value...
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titleThe diagnostic and prognostic value of MRP8/MRP14 in intrahepatic cholangiocarcinoma.
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