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A biosensor for the detection of single base mismatches in microRNA

Graphene oxide quenches fluorescence corresponding to only a mismatched target due to selective denaturing of the thermo-unstable duplex composed of probe peptide nucleic acid and single base mismatched target RNA and thus, the fluorescence signal only from perfectly matched target RNA is measured.

Journal Title: Chemical Communications: Chem Comm September 2015, Vol.51(78), pp.14597-14600
Main Author: Lee, Jieon
Other Authors: Park, Ginam , Min, Dal-Hee
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c5cc04706d
Link: http://search.proquest.com/docview/1753508991/?pq-origsite=primo
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recordid: proquest1753508991
title: A biosensor for the detection of single base mismatches in microRNA
format: Article
creator:
  • Lee, Jieon
  • Park, Ginam
  • Min, Dal-Hee
subjects:
  • Biosensors
  • Fluorescence
  • Graphene
  • Ribonucleic Acids
  • Peptides
  • Oxides
  • Nucleic Acids
  • Miscellaneous Sciences (So)
  • Chemical and Electrochemical Properties (MD)
  • Chemical and Electrochemical Properties (Ep)
  • Chemical and Electrochemical Properties (Ed)
  • Chemical and Electrochemical Properties (EC)
ispartof: Chemical Communications: Chem Comm, September 2015, Vol.51(78), pp.14597-14600
description: Graphene oxide quenches fluorescence corresponding to only a mismatched target due to selective denaturing of the thermo-unstable duplex composed of probe peptide nucleic acid and single base mismatched target RNA and thus, the fluorescence signal only from perfectly matched target RNA is measured.
language: eng
source:
identifier: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c5cc04706d
fulltext: fulltext
issn:
  • 13597345
  • 1359-7345
  • 1364548X
  • 1364-548X
url: Link


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descriptionGraphene oxide quenches fluorescence corresponding to only a mismatched target due to selective denaturing of the thermo-unstable duplex composed of probe peptide nucleic acid and single base mismatched target RNA and thus, the fluorescence signal only from perfectly matched target RNA is measured.
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abstractGraphene oxide quenches fluorescence corresponding to only a mismatched target due to selective denaturing of the thermo-unstable duplex composed of probe peptide nucleic acid and single base mismatched target RNA and thus, the fluorescence signal only from perfectly matched target RNA is measured.
doi10.1039/c5cc04706d
urlhttp://search.proquest.com/docview/1753508991/
date2015-09-01