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Chronic Exposure to Diquat Causes Reproductive Toxicity in Female Mice.

Diquat is a bipyridyl herbicide that has been widely used as a model chemical for in vivo studies of oxidative stress due to its generation of superoxide anions, and cytotoxic effects. There is little information regarding the toxic effects of diquat on the female reproductive system, particularly o... Full description

Journal Title: PloS one 2016, Vol.11(1), p.e0147075
Main Author: Zhang, Jia-Qing
Other Authors: Gao, Bin-Wen , Wang, Jing , Wang, Xian-Wei , Ren, Qiao-Ling , Chen, Jun-Feng , Ma, Qiang , Xing, Bao-Song
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0147075
Link: http://search.proquest.com/docview/1760888856/?pq-origsite=primo
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title: Chronic Exposure to Diquat Causes Reproductive Toxicity in Female Mice.
format: Article
creator:
  • Zhang, Jia-Qing
  • Gao, Bin-Wen
  • Wang, Jing
  • Wang, Xian-Wei
  • Ren, Qiao-Ling
  • Chen, Jun-Feng
  • Ma, Qiang
  • Xing, Bao-Song
subjects:
  • Animals–Drug Effects
  • Apoptosis–Toxicity
  • Diquat–Drug Effects
  • Female–Metabolism
  • Gene Expression Regulation–Pathology
  • Granulosa Cells–Metabolism
  • Mice–Pathology
  • Mice, Inbred Icr–Metabolism
  • Polar Bodies–Drug Effects
  • Reactive Oxygen Species–Drug Effects
  • Reproduction–Drug Effects
  • Reactive Oxygen Species
  • Diquat
ispartof: PloS one, 2016, Vol.11(1), p.e0147075
description: Diquat is a bipyridyl herbicide that has been widely used as a model chemical for in vivo studies of oxidative stress due to its generation of superoxide anions, and cytotoxic effects. There is little information regarding the toxic effects of diquat on the female reproductive system, particularly ovarian function. Thus, we investigated the reproductive toxic effects of diquat on female mice. Chronic exposure to diquat reduced ovary weights, induced ovarian oxidative stress, resulted in granulosa cell apoptosis, and disrupted oocyte developmental competence, as shown by reactive oxygen species (ROS) accumulation, decreased polar body extrusion rates and increased apoptosis-related genes expression. Additionally, after diquat treatment, the numbers of fetal mice and litter sizes were significantly reduced compared to those of control mice. Thus, our results indicated that chronic exposure to diquat induced reproductive toxicity in female mice by promoting the ROS production of gruanousa cells and ooctyes, impairing follicle development, inducing apoptosis, and reducing oocyte quality. In conclusion, our findings indicate that diquat can be used as a potent and efficient chemical for in vivo studies of female reproductive toxicity induced by oxidative stress. Moreover, the findings from this study will further enlarge imitative research investigating the effect of ovarian damage induced by oxidative stress on reproductive performance and possible mechanisms of action in large domestic animals.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0147075
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleChronic Exposure to Diquat Causes Reproductive Toxicity in Female Mice.
creatorZhang, Jia-Qing ; Gao, Bin-Wen ; Wang, Jing ; Wang, Xian-Wei ; Ren, Qiao-Ling ; Chen, Jun-Feng ; Ma, Qiang ; Xing, Bao-Song
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identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0147075
subjectAnimals–Drug Effects ; Apoptosis–Toxicity ; Diquat–Drug Effects ; Female–Metabolism ; Gene Expression Regulation–Pathology ; Granulosa Cells–Metabolism ; Mice–Pathology ; Mice, Inbred Icr–Metabolism ; Polar Bodies–Drug Effects ; Reactive Oxygen Species–Drug Effects ; Reproduction–Drug Effects ; Reactive Oxygen Species ; Diquat
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descriptionDiquat is a bipyridyl herbicide that has been widely used as a model chemical for in vivo studies of oxidative stress due to its generation of superoxide anions, and cytotoxic effects. There is little information regarding the toxic effects of diquat on the female reproductive system, particularly ovarian function. Thus, we investigated the reproductive toxic effects of diquat on female mice. Chronic exposure to diquat reduced ovary weights, induced ovarian oxidative stress, resulted in granulosa cell apoptosis, and disrupted oocyte developmental competence, as shown by reactive oxygen species (ROS) accumulation, decreased polar body extrusion rates and increased apoptosis-related genes expression. Additionally, after diquat treatment, the numbers of fetal mice and litter sizes were significantly reduced compared to those of control mice. Thus, our results indicated that chronic exposure to diquat induced reproductive toxicity in female mice by promoting the ROS production of gruanousa cells and ooctyes, impairing follicle development, inducing apoptosis, and reducing oocyte quality. In conclusion, our findings indicate that diquat can be used as a potent and efficient chemical for in vivo studies of female reproductive toxicity induced by oxidative stress. Moreover, the findings from this study will further enlarge imitative research investigating the effect of ovarian damage induced by oxidative stress on reproductive performance and possible mechanisms of action in large domestic animals.
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titleChronic Exposure to Diquat Causes Reproductive Toxicity in Female Mice.
authorZhang, Jia-Qing ; Gao, Bin-Wen ; Wang, Jing ; Wang, Xian-Wei ; Ren, Qiao-Ling ; Chen, Jun-Feng ; Ma, Qiang ; Xing, Bao-Song
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