schliessen

Filtern

 

Bibliotheken

Periventricular hyperintensities are associated with elevated cerebral amyloid.

OBJECTIVETo investigate the association between periventricular white mater hyperintensities (PVWMH) and biomarkers of elevated cerebral β-amyloid (Aβ) in the Alzheimer's Disease Neuroimaging Initiative, a large prospective multicenter observational study. METHODSThe burden of frontal, parietal, and... Full description

Journal Title: Neurology February 9, 2016, Vol.86(6), pp.535-543
Main Author: Marnane, Michael
Other Authors: Al-Jawadi, Osama O , Mortazavi, Shervin , Pogorzelec, Kathleen J , Wang, Bing Wei , Feldman, Howard H , Hsiung, Ging-Yuek R , Marnane, Michael
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1526-632X ; DOI: 10.1212/WNL.0000000000002352
Link: http://search.proquest.com/docview/1764341188/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1764341188
title: Periventricular hyperintensities are associated with elevated cerebral amyloid.
format: Article
creator:
  • Marnane, Michael
  • Al-Jawadi, Osama O
  • Mortazavi, Shervin
  • Pogorzelec, Kathleen J
  • Wang, Bing Wei
  • Feldman, Howard H
  • Hsiung, Ging-Yuek R
  • Marnane, Michael
subjects:
  • Adult–Cerebrospinal Fluid
  • Aged–Cerebrospinal Fluid
  • Aged, 80 and Over–Pathology
  • Amyloid Beta-Peptides–Cerebrospinal Fluid
  • Biomarkers–Diagnosis
  • Cerebral Ventricles–Pathology
  • Cognitive Dysfunction–Methods
  • Female–Methods
  • Humans–Methods
  • Magnetic Resonance Imaging–Methods
  • Male–Methods
  • Middle Aged–Methods
  • Positron-Emission Tomography–Methods
  • Prospective Studies–Methods
  • Abridged
  • Amyloid Beta-Peptides
  • Biomarkers
ispartof: Neurology, February 9, 2016, Vol.86(6), pp.535-543
description: OBJECTIVETo investigate the association between periventricular white mater hyperintensities (PVWMH) and biomarkers of elevated cerebral β-amyloid (Aβ) in the Alzheimer's Disease Neuroimaging Initiative, a large prospective multicenter observational study. METHODSThe burden of frontal, parietal, and occipital PVWMH on 3T fluid-attenuated inversion recovery MRI was evaluated in 698 cognitively normal participants and participants with mild cognitive impairment (MCI) using a novel semiquantitative visual rating scale. Results were correlated with CSF-Aβ, florbetapir-PET, and fluorodeoxyglucose (FDG)-PET. RESULTSIncreased burden of parietal, occipital, and frontal PVWMH was associated with elevated cerebral amyloid evidenced by high florbetapir-PET signal (p < 0.01) and low CSF-Aβ (p < 0.01). In logistic regression models, including PVWMH, age, sex, APOE status, vascular risk factors, pulse pressure, vascular secondary prevention medications, education, ethnicity, and race, parietal, occipital,...
language: eng
source:
identifier: E-ISSN: 1526-632X ; DOI: 10.1212/WNL.0000000000002352
fulltext: fulltext
issn:
  • 1526632X
  • 1526-632X
url: Link


@attributes
ID36826805
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1764341188
sourceidproquest
recordidTN_proquest1764341188
sourcesystemPC
pqid1764341188
display
typearticle
titlePeriventricular hyperintensities are associated with elevated cerebral amyloid.
creatorMarnane, Michael ; Al-Jawadi, Osama O ; Mortazavi, Shervin ; Pogorzelec, Kathleen J ; Wang, Bing Wei ; Feldman, Howard H ; Hsiung, Ging-Yuek R ; Marnane, Michael
contributorWeiner, Michael (correspondence author) ; Aisen, Paul (record owner) ; Weiner, Michael ; Aisen, Paul ; Petersen, Ronald ; Jack, Clifford R ; Jagust, William ; Trojanowki, John Q ; Toga, Arthur W ; Beckett, Laurel ; Green, Robert C ; Saykin, Andrew J ; Morris, John ; Liu, Enchi ; Green, Robert C ; Montine, Tom ; Petersen, Ronald ; Aisen, Paul ; Gamst, Anthony ; Thomas
ispartofNeurology, February 9, 2016, Vol.86(6), pp.535-543
identifierE-ISSN: 1526-632X ; DOI: 10.1212/WNL.0000000000002352
subjectAdult–Cerebrospinal Fluid ; Aged–Cerebrospinal Fluid ; Aged, 80 and Over–Pathology ; Amyloid Beta-Peptides–Cerebrospinal Fluid ; Biomarkers–Diagnosis ; Cerebral Ventricles–Pathology ; Cognitive Dysfunction–Methods ; Female–Methods ; Humans–Methods ; Magnetic Resonance Imaging–Methods ; Male–Methods ; Middle Aged–Methods ; Positron-Emission Tomography–Methods ; Prospective Studies–Methods ; Abridged ; Amyloid Beta-Peptides ; Biomarkers
descriptionOBJECTIVETo investigate the association between periventricular white mater hyperintensities (PVWMH) and biomarkers of elevated cerebral β-amyloid (Aβ) in the Alzheimer's Disease Neuroimaging Initiative, a large prospective multicenter observational study. METHODSThe burden of frontal, parietal, and occipital PVWMH on 3T fluid-attenuated inversion recovery MRI was evaluated in 698 cognitively normal participants and participants with mild cognitive impairment (MCI) using a novel semiquantitative visual rating scale. Results were correlated with CSF-Aβ, florbetapir-PET, and fluorodeoxyglucose (FDG)-PET. RESULTSIncreased burden of parietal, occipital, and frontal PVWMH was associated with elevated cerebral amyloid evidenced by high florbetapir-PET signal (p < 0.01) and low CSF-Aβ (p < 0.01). In logistic regression models, including PVWMH, age, sex, APOE status, vascular risk factors, pulse pressure, vascular secondary prevention medications, education, ethnicity, and race, parietal, occipital,...
languageeng
source
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1764341188/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Marnane, Michael
1Al-Jawadi, Osama O
2Mortazavi, Shervin
3Pogorzelec, Kathleen J
4Wang, Bing Wei
5Feldman, Howard H
6Hsiung, Ging-Yuek R
titlePeriventricular hyperintensities are associated with elevated cerebral amyloid.
descriptionOBJECTIVETo investigate the association between periventricular white mater hyperintensities (PVWMH) and biomarkers of elevated cerebral β-amyloid (Aβ) in the Alzheimer's Disease Neuroimaging Initiative, a large prospective multicenter observational study. METHODSThe burden of frontal, parietal, and occipital PVWMH on 3T fluid-attenuated inversion recovery MRI was evaluated in 698 cognitively normal participants and participants with mild cognitive impairment (MCI) using a novel semiquantitative visual rating scale. Results were correlated with CSF-Aβ, florbetapir-PET, and fluorodeoxyglucose (FDG)-PET. RESULTSIncreased burden of parietal, occipital, and frontal PVWMH was associated with elevated cerebral amyloid evidenced by high florbetapir-PET signal (p < 0.01) and low CSF-Aβ (p < 0.01). In logistic regression models, including PVWMH, age, sex, APOE status, vascular risk factors, pulse pressure, vascular secondary prevention medications, education, ethnicity, and race, parietal, occipital,...
subject
0Adult–Cerebrospinal Fluid
1Aged–Cerebrospinal Fluid
2Aged, 80 and Over–Pathology
3Amyloid Beta-Peptides–Cerebrospinal Fluid
4Biomarkers–Diagnosis
5Cerebral Ventricles–Pathology
6Cognitive Dysfunction–Methods
7Female–Methods
8Humans–Methods
9Magnetic Resonance Imaging–Methods
10Male–Methods
11Middle Aged–Methods
12Positron-Emission Tomography–Methods
13Prospective Studies–Methods
14Abridged
15Amyloid Beta-Peptides
16Biomarkers
general
0English
110.1212/WNL.0000000000002352
2MEDLINE (ProQuest)
3ProQuest Biological Science Collection
4ProQuest Natural Science Collection
5ProQuest SciTech Collection
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
11Biological Science Index (ProQuest)
sourceidproquest
recordidproquest1764341188
issn
01526632X
11526-632X
rsrctypearticle
creationdate2016
addtitleNeurology
searchscope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
scope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
lsr43
01007527false
11007944false
21009130false
310000004false
410000038false
510000050false
610000120false
710000159false
810000238false
910000253false
1010000260false
1110000270false
1210000271false
1310000302false
1410000350false
contributor
0Weiner, Michael
1Aisen, Paul
2Petersen, Ronald
3Jack, Clifford R
4Jagust, William
5Trojanowki, John Q
6Toga, Arthur W
7Beckett, Laurel
8Green, Robert C
9Saykin, Andrew J
10Morris, John
11Liu, Enchi
12Montine, Tom
13Gamst, Anthony
14Thomas, Ronald G
15Donohue, Michael
16Walter, Sarah
17Gessert, Devon
18Sather, Tamie
19Harvey, Danielle
20Kornak, John
21Dale, Anders
22Bernstein, Matthew
23Felmlee, Joel
24Fox, Nick
25Thompson, Paul
26Schuff, Norbert
27Alexander, Gene
28Decarli, Charles
29Bandy, Dan
30Koeppe, Robert A
31Foster, Norm
32Reiman, Eric M
33Chen, Kewei
34Mathis, Chet
35Cairns, Nigel J
36Taylor-Reinwald, Lisa
37Trojanowki, J Q
38Shaw, Les
39Lee, Virginia M Y
40Korecka, Magdalena
41Crawford, Karen
42Neu, Scott
43Foroud, Tatiana M
44Potkin, Steven
45Shen, Li
46Kachaturian, Zaven
47Frank, Richard
48Snyder, Peter J
49Molchan, Susan
50Kaye, Jeffrey
51Quinn, Joseph
52Lind, Betty
53Dolen, Sara
54Schneider, Lon S
55Pawluczyk, Sonia
56Spann, Bryan M
57Brewer, James
58Vanderswag, Helen
59Heidebrink, Judith L
60Lord, Joanne L
61Johnson, Kris
62Doody, Rachelle S
63Villanueva-Meyer, Javier
64Chowdhury, Munir
65Stern, Yaakov
66Honig, Lawrence S
67Bell, Karen L
68Morris, John C
69Ances, Beau
70Carroll, Maria
71Leon, Sue
72Mintun, Mark A
73Schneider, Stacy
74Marson, Daniel
75Griffith, Randall
76Clark, David
77Grossman, Hillel
78Mitsis, Effie
79Romirowsky, Aliza
80Detoledo-Morrell, Leyla
81Shah, Raj C
82Duara, Ranjan
83Varon, Daniel
84Roberts, Peggy
85Albert, Marilyn
86Onyike, Chiadi
87Kielb, Stephanie
88Rusinek, Henry
89de Leon, Mony J
90Glodzik, Lidia
91De Santi, Susan
92Doraiswamy, P Murali
93Petrella, Jeffrey R
94Coleman, R Edward
95Arnold, Steven E
96Karlawish, Jason H
97Wolk, David
98Smith, Charles D
99Jicha, Greg
100...
startdate20160209
enddate20160209
citationpf 535 pt 543 vol 86 issue 6
lsr30VSR-Enriched:[issn, pqid]
sort
titlePeriventricular hyperintensities are associated with elevated cerebral amyloid.
authorMarnane, Michael ; Al-Jawadi, Osama O ; Mortazavi, Shervin ; Pogorzelec, Kathleen J ; Wang, Bing Wei ; Feldman, Howard H ; Hsiung, Ging-Yuek R ; Marnane, Michael
creationdate20160209
lso0120160209
facets
frbrgroupid8283009252784357504
frbrtype5
newrecords20181218
languageeng
creationdate2016
topic
0Adult–Cerebrospinal Fluid
1Aged–Cerebrospinal Fluid
2Aged, 80 and Over–Pathology
3Amyloid Beta-Peptides–Cerebrospinal Fluid
4Biomarkers–Diagnosis
5Cerebral Ventricles–Pathology
6Cognitive Dysfunction–Methods
7Female–Methods
8Humans–Methods
9Magnetic Resonance Imaging–Methods
10Male–Methods
11Middle Aged–Methods
12Positron-Emission Tomography–Methods
13Prospective Studies–Methods
14Abridged
15Amyloid Beta-Peptides
16Biomarkers
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
9Biological Science Index (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0Marnane, Michael
1Al-Jawadi, Osama O
2Mortazavi, Shervin
3Pogorzelec, Kathleen J
4Wang, Bing Wei
5Feldman, Howard H
6Hsiung, Ging-Yuek R
7Weiner, Michael
8Aisen, Paul
9Petersen, Ronald
10Jack, Clifford R
11Jagust, William
12Trojanowki, John Q
13Toga, Arthur W
14Beckett, Laurel
15Green, Robert C
16Saykin, Andrew J
17Morris, John
18Liu, Enchi
19Montine, Tom
20Gamst, Anthony
21Thomas, Ronald G
22Donohue, Michael
23Walter, Sarah
24Gessert, Devon
25Sather, Tamie
26Harvey, Danielle
27Kornak, John
28Dale, Anders
29Bernstein, Matthew
30Felmlee, Joel
31Fox, Nick
32Thompson, Paul
33Schuff, Norbert
34Alexander, Gene
35Decarli, Charles
36Bandy, Dan
37Koeppe, Robert A
38Foster, Norm
39Reiman, Eric M
40Chen, Kewei
41Mathis, Chet
42Cairns, Nigel J
43Taylor-Reinwald, Lisa
44Trojanowki, J Q
45Shaw, Les
46Lee, Virginia M Y
47Korecka, Magdalena
48Crawford, Karen
49Neu, Scott
50Foroud, Tatiana M
51Potkin, Steven
52Shen, Li
53Kachaturian, Zaven
54Frank, Richard
55Snyder, Peter J
56Molchan, Susan
57Kaye, Jeffrey
58Quinn, Joseph
59Lind, Betty
60Dolen, Sara
61Schneider, Lon S
62Pawluczyk, Sonia
63Spann, Bryan M
64Brewer, James
65Vanderswag, Helen
66Heidebrink, Judith L
67Lord, Joanne L
68Johnson, Kris
69Doody, Rachelle S
70Villanueva-Meyer, Javier
71Chowdhury, Munir
72Stern, Yaakov
73Honig, Lawrence S
74Bell, Karen L
75Morris, John C
76Ances, Beau
77Carroll, Maria
78Leon, Sue
79Mintun, Mark A
80Schneider, Stacy
81Marson, Daniel
82Griffith, Randall
83Clark, David
84Grossman, Hillel
85Mitsis, Effie
86Romirowsky, Aliza
87Detoledo-Morrell, Leyla
88Shah, Raj C
89Duara, Ranjan
90Varon, Daniel
91Roberts, Peggy
92Albert, Marilyn
93Onyike, Chiadi
94Kielb, Stephanie
95Rusinek, Henry
96de Leon, Mony J
97Glodzik, Lidia
98De Santi, Susan
99Doraiswamy, P Murali
100...
jtitleNeurology
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Marnane
1Al-Jawadi
2Mortazavi
3Pogorzelec
4Wang
5Feldman
6Hsiung
aufirst
0Michael
1Osama O
2Shervin
3Kathleen J
4Bing Wei
5Howard H
6Ging-Yuek R
au
0Marnane, Michael
1Al-Jawadi, Osama O
2Mortazavi, Shervin
3Pogorzelec, Kathleen J
4Wang, Bing Wei
5Feldman, Howard H
6Hsiung, Ging-Yuek R
addau
0Weiner, Michael
1Aisen, Paul
2Petersen, Ronald
3Jack, Clifford R
4Jagust, William
5Trojanowki, John Q
6Toga, Arthur W
7Beckett, Laurel
8Green, Robert C
9Saykin, Andrew J
10Morris, John
11Liu, Enchi
12Montine, Tom
13Gamst, Anthony
14Thomas, Ronald G
15Donohue, Michael
16Walter, Sarah
17Gessert, Devon
18Sather, Tamie
19Harvey, Danielle
20Kornak, John
21Dale, Anders
22Bernstein, Matthew
23Felmlee, Joel
24Fox, Nick
25Thompson, Paul
26Schuff, Norbert
27Alexander, Gene
28DeCarli, Charles
29Bandy, Dan
30Koeppe, Robert A
31Foster, Norm
32Reiman, Eric M
33Chen, Kewei
34Mathis, Chet
35Cairns, Nigel J
36Taylor-Reinwald, Lisa
37Trojanowki, J Q
38Shaw, Les
39Lee, Virginia M Y
40Korecka, Magdalena
41Crawford, Karen
42Neu, Scott
43Foroud, Tatiana M
44Potkin, Steven
45Shen, Li
46Kachaturian, Zaven
47Frank, Richard
48Snyder, Peter J
49Molchan, Susan
50Kaye, Jeffrey
51Quinn, Joseph
52Lind, Betty
53Dolen, Sara
54Schneider, Lon S
55Pawluczyk, Sonia
56Spann, Bryan M
57Brewer, James
58Vanderswag, Helen
59Heidebrink, Judith L
60Lord, Joanne L
61Johnson, Kris
62Doody, Rachelle S
63Villanueva-Meyer, Javier
64Chowdhury, Munir
65Stern, Yaakov
66Honig, Lawrence S
67Bell, Karen L
68Morris, John C
69Ances, Beau
70Carroll, Maria
71Leon, Sue
72Mintun, Mark A
73Schneider, Stacy
74Marson, Daniel
75Griffith, Randall
76Clark, David
77Grossman, Hillel
78Mitsis, Effie
79Romirowsky, Aliza
80deToledo-Morrell, Leyla
81Shah, Raj C
82Duara, Ranjan
83Varon, Daniel
84Roberts, Peggy
85Albert, Marilyn
86Onyike, Chiadi
87Kielb, Stephanie
88Rusinek, Henry
89de Leon, Mony J
90Glodzik, Lidia
91De Santi, Susan
92Doraiswamy, P Murali
93Petrella, Jeffrey R
94Coleman, R Edward
95Arnold, Steven E
96Karlawish, Jason H
97Wolk, David
98Smith, Charles D
99Jicha, Greg
100...
atitlePeriventricular hyperintensities are associated with elevated cerebral amyloid.
jtitleNeurology
risdate20160209
volume86
issue6
spage535
epage543
pages535-543
eissn1526-632X
formatjournal
genrearticle
ristypeJOUR
abstractOBJECTIVETo investigate the association between periventricular white mater hyperintensities (PVWMH) and biomarkers of elevated cerebral β-amyloid (Aβ) in the Alzheimer's Disease Neuroimaging Initiative, a large prospective multicenter observational study. METHODSThe burden of frontal, parietal, and occipital PVWMH on 3T fluid-attenuated inversion recovery MRI was evaluated in 698 cognitively normal participants and participants with mild cognitive impairment (MCI) using a novel semiquantitative visual rating scale. Results were correlated with CSF-Aβ, florbetapir-PET, and fluorodeoxyglucose (FDG)-PET. RESULTSIncreased burden of parietal, occipital, and frontal PVWMH was associated with elevated cerebral amyloid evidenced by high florbetapir-PET signal (p < 0.01) and low CSF-Aβ (p < 0.01). In logistic regression models, including PVWMH, age, sex, APOE status, vascular risk factors, pulse pressure, vascular secondary prevention medications, education, ethnicity, and race, parietal, occipital,...
doi10.1212/WNL.0000000000002352
urlhttp://search.proquest.com/docview/1764341188/
issn00283878
date2016-02-09