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Predictors of Increased Carotid Intima-Media Thickness in Youth With Type 1 Diabetes: The SEARCH CVD Study

Youth with type 1 diabetes have worse cardiovascular (CV) risk factors and higher carotid intima-media thickness (IMT) than their peers without diabetes. Whether the burden of CV risk factors over time is associated with carotid IMT at follow-up in youth with type 1 diabetes is not known. Two hundre... Full description

Journal Title: Diabetes Care Mar 2016, Vol.39(3), p.418
Main Author: Shah, Amy
Other Authors: Dabelea, Dana , Fino, Nora , Dolan, Lawrence , Wadwa, R , D'Agostino, Ralph , Hamman, Richard , Marcovina, Santica , Daniels, Stephen , Urbina, Elaine
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 01495992 ; DOI: 10.2337/dc15-1963
Link: http://search.proquest.com/docview/1774913979/?pq-origsite=primo
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title: Predictors of Increased Carotid Intima-Media Thickness in Youth With Type 1 Diabetes: The SEARCH CVD Study
format: Article
creator:
  • Shah, Amy
  • Dabelea, Dana
  • Fino, Nora
  • Dolan, Lawrence
  • Wadwa, R
  • D'Agostino, Ralph
  • Hamman, Richard
  • Marcovina, Santica
  • Daniels, Stephen
  • Urbina, Elaine
subjects:
  • Diabetes
  • Cardiovascular Disease
  • Risk Factors
  • Carotid Arteries
  • Thickness Measurement
ispartof: Diabetes Care, Mar 2016, Vol.39(3), p.418
description: Youth with type 1 diabetes have worse cardiovascular (CV) risk factors and higher carotid intima-media thickness (IMT) than their peers without diabetes. Whether the burden of CV risk factors over time is associated with carotid IMT at follow-up in youth with type 1 diabetes is not known. Two hundred ninety-eight youth with type 1 diabetes (mean age 13.3 ± 2.9 years, 87.6% non-Hispanic white, 53.7% male) had two study visits 5 years apart. CV risk factors, including BMI, lipids, blood pressure, hemoglobin A..., and smoking status, were assessed at both visits, and carotid IMT was measured at follow-up using B-mode ultrasonography. Linear regression models with an area under the curve measurement that incorporated the baseline and follow-up CV risk factors were used to evaluate the relationship with carotid IMT at follow-up. All CV risk factors worsened significantly over time (except LDL cholesterol) (P < 0.05). From baseline to follow-up, the number of abnormal CV risk factors also increased...
language: eng
source:
identifier: ISSN: 01495992 ; DOI: 10.2337/dc15-1963
fulltext: fulltext
issn:
  • 01495992
  • 0149-5992
url: Link


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titlePredictors of Increased Carotid Intima-Media Thickness in Youth With Type 1 Diabetes: The SEARCH CVD Study
creatorShah, Amy ; Dabelea, Dana ; Fino, Nora ; Dolan, Lawrence ; Wadwa, R ; D'Agostino, Ralph ; Hamman, Richard ; Marcovina, Santica ; Daniels, Stephen ; Urbina, Elaine
ispartofDiabetes Care, Mar 2016, Vol.39(3), p.418
identifierISSN: 01495992 ; DOI: 10.2337/dc15-1963
subjectDiabetes ; Cardiovascular Disease ; Risk Factors ; Carotid Arteries ; Thickness Measurement
descriptionYouth with type 1 diabetes have worse cardiovascular (CV) risk factors and higher carotid intima-media thickness (IMT) than their peers without diabetes. Whether the burden of CV risk factors over time is associated with carotid IMT at follow-up in youth with type 1 diabetes is not known. Two hundred ninety-eight youth with type 1 diabetes (mean age 13.3 ± 2.9 years, 87.6% non-Hispanic white, 53.7% male) had two study visits 5 years apart. CV risk factors, including BMI, lipids, blood pressure, hemoglobin A..., and smoking status, were assessed at both visits, and carotid IMT was measured at follow-up using B-mode ultrasonography. Linear regression models with an area under the curve measurement that incorporated the baseline and follow-up CV risk factors were used to evaluate the relationship with carotid IMT at follow-up. All CV risk factors worsened significantly over time (except LDL cholesterol) (P < 0.05). From baseline to follow-up, the number of abnormal CV risk factors also increased...
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descriptionYouth with type 1 diabetes have worse cardiovascular (CV) risk factors and higher carotid intima-media thickness (IMT) than their peers without diabetes. Whether the burden of CV risk factors over time is associated with carotid IMT at follow-up in youth with type 1 diabetes is not known. Two hundred ninety-eight youth with type 1 diabetes (mean age 13.3 ± 2.9 years, 87.6% non-Hispanic white, 53.7% male) had two study visits 5 years apart. CV risk factors, including BMI, lipids, blood pressure, hemoglobin A..., and smoking status, were assessed at both visits, and carotid IMT was measured at follow-up using B-mode ultrasonography. Linear regression models with an area under the curve measurement that incorporated the baseline and follow-up CV risk factors were used to evaluate the relationship with carotid IMT at follow-up. All CV risk factors worsened significantly over time (except LDL cholesterol) (P < 0.05). From baseline to follow-up, the number of abnormal CV risk factors also increased...
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titlePredictors of Increased Carotid Intima-Media Thickness in Youth With Type 1 Diabetes: The SEARCH CVD Study
authorShah, Amy ; Dabelea, Dana ; Fino, Nora ; Dolan, Lawrence ; Wadwa, R ; D'Agostino, Ralph ; Hamman, Richard ; Marcovina, Santica ; Daniels, Stephen ; Urbina, Elaine
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abstractYouth with type 1 diabetes have worse cardiovascular (CV) risk factors and higher carotid intima-media thickness (IMT) than their peers without diabetes. Whether the burden of CV risk factors over time is associated with carotid IMT at follow-up in youth with type 1 diabetes is not known. Two hundred ninety-eight youth with type 1 diabetes (mean age 13.3 ± 2.9 years, 87.6% non-Hispanic white, 53.7% male) had two study visits 5 years apart. CV risk factors, including BMI, lipids, blood pressure, hemoglobin A..., and smoking status, were assessed at both visits, and carotid IMT was measured at follow-up using B-mode ultrasonography. Linear regression models with an area under the curve measurement that incorporated the baseline and follow-up CV risk factors were used to evaluate the relationship with carotid IMT at follow-up. All CV risk factors worsened significantly over time (except LDL cholesterol) (P < 0.05). From baseline to follow-up, the number of abnormal CV risk factors also increased...
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doi10.2337/dc15-1963
urlhttp://search.proquest.com/docview/1774913979/
pages418-41825
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date2016-03-01