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Decreased TPD52 expression is associated with poor prognosis in primary hepatocellular carcinoma.

Tumor protein D52 (TPD52) has been indicated to be involved in tumorigenesis of various malignancies. But its role in hepatocellular carcinoma (HCC) is unknown. This study aimed to explore the expression of TPD52 in HCC samples and cell lines using real-time quantitative PCR, western blotting, and i... Full description

Journal Title: Oncotarget February 2, 2016, Vol.7(5), pp.6323-6334
Main Author: Wang, Ying
Other Authors: Chen, Chang-Long , Pan, Qiu-Zhong , Wu, Ying-Yuan , Zhao, Jing-Jing , Jiang, Shan-Shan , Chao, Jie , Zhang, Xiao-Fei , Zhang, Hong-Xia , Zhou, Zi-Qi , Tang, Yan , Huang, Xu-Qiong , Zhang, Jian-Hua , Xia, Jian-Chuan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.6319
Link: http://search.proquest.com/docview/1775168014/?pq-origsite=primo
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title: Decreased TPD52 expression is associated with poor prognosis in primary hepatocellular carcinoma.
format: Article
creator:
  • Wang, Ying
  • Chen, Chang-Long
  • Pan, Qiu-Zhong
  • Wu, Ying-Yuan
  • Zhao, Jing-Jing
  • Jiang, Shan-Shan
  • Chao, Jie
  • Zhang, Xiao-Fei
  • Zhang, Hong-Xia
  • Zhou, Zi-Qi
  • Tang, Yan
  • Huang, Xu-Qiong
  • Zhang, Jian-Hua
  • Xia, Jian-Chuan
subjects:
  • Carcinoma, Hepatocellular–Genetics
  • Cell Line, Tumor–Metabolism
  • Cyclin-Dependent Kinase Inhibitor P21–Pathology
  • Female–Biosynthesis
  • Hep G2 Cells–Genetics
  • Humans–Genetics
  • Immunohistochemistry–Metabolism
  • Liver Neoplasms–Pathology
  • Male–Biosynthesis
  • Middle Aged–Genetics
  • Neoplasm Proteins–Genetics
  • Prognosis–Genetics
  • Survival Rate–Genetics
  • Transfection–Genetics
  • Cdkn1a Protein, Human
  • Cyclin-Dependent Kinase Inhibitor P21
  • Neoplasm Proteins
  • Tpd52 Protein, Human
  • Tpd52
  • Hepatocellular Carcinoma
ispartof: Oncotarget, February 2, 2016, Vol.7(5), pp.6323-6334
description: Tumor protein D52 (TPD52) has been indicated to be involved in tumorigenesis of various malignancies. But its role in hepatocellular carcinoma (HCC) is unknown. This study aimed to explore the expression of TPD52 in HCC samples and cell lines using real-time quantitative PCR, western blotting, and immunohistochemistry. The prognostic value of TPD52 in HCC was also analysed. Meanwhile, the mechanism of TPD52 in hepatocarcinogenesis was further investigated by western blotting, immunohistochemistry, over-express and knockdown studies. We found that TPD52 expression was significantly decreased in the HCC tissues and HCC cell lines. TPD52 expression was significantly correlated with tumor-nodes-metastasis (TNM) stage. Kaplan–Meier survival curves showed that high TPD52 expression was associated with improved overall survival (OS) and disease-free survival (DFS) in HCC patients. Multivariate analysis indicated that TPD52 expression was an independent prognostic marker for the OS and DFS of patients. In addition, TPD52 expression was positively correlated with p21 and p53 expression, and was negatively correlated with MDM2, BCL2 and P-GSK-3β expression in HCC. In conclusions, our findings suggested that TPD52 is a potential tumor suppressor in HCC. It may be a novel prognostic biomarker and molecular therapy target for HCC.
language: eng
source:
identifier: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.6319
fulltext: fulltext
issn:
  • 19492553
  • 1949-2553
url: Link


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titleDecreased TPD52 expression is associated with poor prognosis in primary hepatocellular carcinoma.
creatorWang, Ying ; Chen, Chang-Long ; Pan, Qiu-Zhong ; Wu, Ying-Yuan ; Zhao, Jing-Jing ; Jiang, Shan-Shan ; Chao, Jie ; Zhang, Xiao-Fei ; Zhang, Hong-Xia ; Zhou, Zi-Qi ; Tang, Yan ; Huang, Xu-Qiong ; Zhang, Jian-Hua ; Xia, Jian-Chuan
contributorWang, Ying (correspondence author) ; Wang, Ying (record owner)
ispartofOncotarget, February 2, 2016, Vol.7(5), pp.6323-6334
identifierE-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.6319
subjectCarcinoma, Hepatocellular–Genetics ; Cell Line, Tumor–Metabolism ; Cyclin-Dependent Kinase Inhibitor P21–Pathology ; Female–Biosynthesis ; Hep G2 Cells–Genetics ; Humans–Genetics ; Immunohistochemistry–Metabolism ; Liver Neoplasms–Pathology ; Male–Biosynthesis ; Middle Aged–Genetics ; Neoplasm Proteins–Genetics ; Prognosis–Genetics ; Survival Rate–Genetics ; Transfection–Genetics ; Cdkn1a Protein, Human ; Cyclin-Dependent Kinase Inhibitor P21 ; Neoplasm Proteins ; Tpd52 Protein, Human ; Tpd52 ; Hepatocellular Carcinoma
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descriptionTumor protein D52 (TPD52) has been indicated to be involved in tumorigenesis of various malignancies. But its role in hepatocellular carcinoma (HCC) is unknown. This study aimed to explore the expression of TPD52 in HCC samples and cell lines using real-time quantitative PCR, western blotting, and immunohistochemistry. The prognostic value of TPD52 in HCC was also analysed. Meanwhile, the mechanism of TPD52 in hepatocarcinogenesis was further investigated by western blotting, immunohistochemistry, over-express and knockdown studies. We found that TPD52 expression was significantly decreased in the HCC tissues and HCC cell lines. TPD52 expression was significantly correlated with tumor-nodes-metastasis (TNM) stage. Kaplan–Meier survival curves showed that high TPD52 expression was associated with improved overall survival (OS) and disease-free survival (DFS) in HCC patients. Multivariate analysis indicated that TPD52 expression was an independent prognostic marker for the OS and DFS of patients. In addition, TPD52 expression was positively correlated with p21 and p53 expression, and was negatively correlated with MDM2, BCL2 and P-GSK-3β expression in HCC. In conclusions, our findings suggested that TPD52 is a potential tumor suppressor in HCC. It may be a novel prognostic biomarker and molecular therapy target for HCC.
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titleDecreased TPD52 expression is associated with poor prognosis in primary hepatocellular carcinoma.
authorWang, Ying ; Chen, Chang-Long ; Pan, Qiu-Zhong ; Wu, Ying-Yuan ; Zhao, Jing-Jing ; Jiang, Shan-Shan ; Chao, Jie ; Zhang, Xiao-Fei ; Zhang, Hong-Xia ; Zhou, Zi-Qi ; Tang, Yan ; Huang, Xu-Qiong ; Zhang, Jian-Hua ; Xia, Jian-Chuan
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