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Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial.

BACKGROUNDThe role of branched-chain amino acids (BCAAs) in cardiovascular disease (CVD) remains poorly understood. We hypothesized that baseline BCAA concentrations predict future risk of CVD and that a Mediterranean diet (MedDiet) intervention may counteract this effect. METHODSWe developed a case... Full description

Journal Title: Clinical chemistry April 2016, Vol.62(4), pp.582-592
Main Author: Ruiz-Canela, Miguel
Other Authors: Toledo, Estefania , Clish, Clary B , Hruby, Adela , Liang, Liming , Salas-Salvadó, Jordi , Razquin, Cristina , Corella, Dolores , Estruch, Ramón , Ros, Emilio , Fitó, Montserrat , Gómez-Gracia, Enrique , Arós, Fernando , Fiol, Miquel , Lapetra
Format: Electronic Article Electronic Article
Language: English
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ID: E-ISSN: 1530-8561 ; DOI: 10.1373/clinchem.2015.251710
Link: http://search.proquest.com/docview/1777078667/?pq-origsite=primo
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title: Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial.
format: Article
creator:
  • Ruiz-Canela, Miguel
  • Toledo, Estefania
  • Clish, Clary B
  • Hruby, Adela
  • Liang, Liming
  • Salas-Salvadó, Jordi
  • Razquin, Cristina
  • Corella, Dolores
  • Estruch, Ramón
  • Ros, Emilio
  • Fitó, Montserrat
  • Gómez-Gracia, Enrique
  • Arós, Fernando
  • Fiol, Miquel
  • Lapetra
subjects:
  • Aged–Blood
  • Amino Acids, Branched-Chain–Blood
  • Cardiovascular Diseases–Diet Therapy
  • Case-Control Studies–Epidemiology
  • Cohort Studies–Statistics & Numerical Data
  • Diet, Mediterranean–Statistics & Numerical Data
  • Female–Statistics & Numerical Data
  • Humans–Statistics & Numerical Data
  • Incidence–Statistics & Numerical Data
  • Male–Statistics & Numerical Data
  • Multivariate Analysis–Statistics & Numerical Data
  • Risk–Statistics & Numerical Data
ispartof: Clinical chemistry, April 2016, Vol.62(4), pp.582-592
description: BACKGROUNDThe role of branched-chain amino acids (BCAAs) in cardiovascular disease (CVD) remains poorly understood. We hypothesized that baseline BCAA concentrations predict future risk of CVD and that a Mediterranean diet (MedDiet) intervention may counteract this effect. METHODSWe developed a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED), with 226 incident CVD cases and 744 noncases. We used LC-MS/MS to measure plasma BCAAs (leucine, isoleucine, and valine), both at baseline and after 1 year of follow-up. The primary outcome was a composite of incident stroke, myocardial infarction, or cardiovascular death. RESULTSAfter adjustment for potential confounders, baseline leucine and isoleucine concentrations were associated with higher CVD risk: the hazard ratios (HRs) for the highest vs lowest quartile were 1.70 (95% CI, 1.05-2.76) and 2.09 (1.27-3.44), respectively. Stronger associations were found for stroke. For both CVD and stroke, we found higher HRs across...
language: eng
source:
identifier: E-ISSN: 1530-8561 ; DOI: 10.1373/clinchem.2015.251710
fulltext: fulltext
issn:
  • 15308561
  • 1530-8561
url: Link


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titlePlasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial.
creatorRuiz-Canela, Miguel ; Toledo, Estefania ; Clish, Clary B ; Hruby, Adela ; Liang, Liming ; Salas-Salvadó, Jordi ; Razquin, Cristina ; Corella, Dolores ; Estruch, Ramón ; Ros, Emilio ; Fitó, Montserrat ; Gómez-Gracia, Enrique ; Arós, Fernando ; Fiol, Miquel ; Lapetra
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descriptionBACKGROUNDThe role of branched-chain amino acids (BCAAs) in cardiovascular disease (CVD) remains poorly understood. We hypothesized that baseline BCAA concentrations predict future risk of CVD and that a Mediterranean diet (MedDiet) intervention may counteract this effect. METHODSWe developed a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED), with 226 incident CVD cases and 744 noncases. We used LC-MS/MS to measure plasma BCAAs (leucine, isoleucine, and valine), both at baseline and after 1 year of follow-up. The primary outcome was a composite of incident stroke, myocardial infarction, or cardiovascular death. RESULTSAfter adjustment for potential confounders, baseline leucine and isoleucine concentrations were associated with higher CVD risk: the hazard ratios (HRs) for the highest vs lowest quartile were 1.70 (95% CI, 1.05-2.76) and 2.09 (1.27-3.44), respectively. Stronger associations were found for stroke. For both CVD and stroke, we found higher HRs across...
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descriptionBACKGROUNDThe role of branched-chain amino acids (BCAAs) in cardiovascular disease (CVD) remains poorly understood. We hypothesized that baseline BCAA concentrations predict future risk of CVD and that a Mediterranean diet (MedDiet) intervention may counteract this effect. METHODSWe developed a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED), with 226 incident CVD cases and 744 noncases. We used LC-MS/MS to measure plasma BCAAs (leucine, isoleucine, and valine), both at baseline and after 1 year of follow-up. The primary outcome was a composite of incident stroke, myocardial infarction, or cardiovascular death. RESULTSAfter adjustment for potential confounders, baseline leucine and isoleucine concentrations were associated with higher CVD risk: the hazard ratios (HRs) for the highest vs lowest quartile were 1.70 (95% CI, 1.05-2.76) and 2.09 (1.27-3.44), respectively. Stronger associations were found for stroke. For both CVD and stroke, we found higher HRs across...
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authorRuiz-Canela, Miguel ; Toledo, Estefania ; Clish, Clary B ; Hruby, Adela ; Liang, Liming ; Salas-Salvadó, Jordi ; Razquin, Cristina ; Corella, Dolores ; Estruch, Ramón ; Ros, Emilio ; Fitó, Montserrat ; Gómez-Gracia, Enrique ; Arós, Fernando ; Fiol, Miquel ; Lapetra
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abstractBACKGROUNDThe role of branched-chain amino acids (BCAAs) in cardiovascular disease (CVD) remains poorly understood. We hypothesized that baseline BCAA concentrations predict future risk of CVD and that a Mediterranean diet (MedDiet) intervention may counteract this effect. METHODSWe developed a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED), with 226 incident CVD cases and 744 noncases. We used LC-MS/MS to measure plasma BCAAs (leucine, isoleucine, and valine), both at baseline and after 1 year of follow-up. The primary outcome was a composite of incident stroke, myocardial infarction, or cardiovascular death. RESULTSAfter adjustment for potential confounders, baseline leucine and isoleucine concentrations were associated with higher CVD risk: the hazard ratios (HRs) for the highest vs lowest quartile were 1.70 (95% CI, 1.05-2.76) and 2.09 (1.27-3.44), respectively. Stronger associations were found for stroke. For both CVD and stroke, we found higher HRs across...
doi10.1373/clinchem.2015.251710
urlhttp://search.proquest.com/docview/1777078667/
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date2016-04-01