schliessen

Filtern

 

Bibliotheken

Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial.

BACKGROUNDThe role of branched-chain amino acids (BCAAs) in cardiovascular disease (CVD) remains poorly understood. We hypothesized that baseline BCAA concentrations predict future risk of CVD and that a Mediterranean diet (MedDiet) intervention may counteract this effect. METHODSWe developed a case... Full description

Journal Title: Clinical chemistry April 2016, Vol.62(4), pp.582-592
Main Author: Ruiz-Canela, Miguel
Other Authors: Toledo, Estefania , Clish, Clary B , Hruby, Adela , Liang, Liming , Salas-Salvadó, Jordi , Razquin, Cristina , Corella, Dolores , Estruch, Ramón , Ros, Emilio , Fitó, Montserrat , Gómez-Gracia, Enrique , Arós, Fernando , Fiol, Miquel , Lapetra, José , Serra-Majem, Lluis , Martínez-González, Miguel A , Hu, Frank B
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1530-8561 ; DOI: 1530-8561 ; DOI: 10.1373/clinchem.2015.251710
Link: http://search.proquest.com/docview/1777078667/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1777078667
title: Plasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial.
format: Article
creator:
  • Ruiz-Canela, Miguel
  • Toledo, Estefania
  • Clish, Clary B
  • Hruby, Adela
  • Liang, Liming
  • Salas-Salvadó, Jordi
  • Razquin, Cristina
  • Corella, Dolores
  • Estruch, Ramón
  • Ros, Emilio
  • Fitó, Montserrat
  • Gómez-Gracia, Enrique
  • Arós, Fernando
  • Fiol, Miquel
  • Lapetra, José
  • Serra-Majem, Lluis
  • Martínez-González, Miguel A
  • Hu, Frank B
subjects:
  • Aged–Blood
  • Amino Acids, Branched-Chain–Blood
  • Cardiovascular Diseases–Diet Therapy
  • Case-Control Studies–Epidemiology
  • Cohort Studies–Statistics & Numerical Data
  • Diet, Mediterranean–Statistics & Numerical Data
  • Female–Statistics & Numerical Data
  • Humans–Statistics & Numerical Data
  • Incidence–Statistics & Numerical Data
  • Male–Statistics & Numerical Data
  • Multivariate Analysis–Statistics & Numerical Data
  • Risk–Statistics & Numerical Data
  • Amino Acids, Branched-Chain
ispartof: Clinical chemistry, April 2016, Vol.62(4), pp.582-592
description: BACKGROUNDThe role of branched-chain amino acids (BCAAs) in cardiovascular disease (CVD) remains poorly understood. We hypothesized that baseline BCAA concentrations predict future risk of CVD and that a Mediterranean diet (MedDiet) intervention may counteract this effect. METHODSWe developed a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED), with 226 incident CVD cases and 744 noncases. We used LC-MS/MS to measure plasma BCAAs (leucine, isoleucine, and valine), both at baseline and after 1 year of follow-up. The primary outcome was a composite of incident stroke, myocardial infarction, or cardiovascular death. RESULTSAfter adjustment for potential confounders, baseline leucine and isoleucine concentrations were associated with higher CVD risk: the hazard ratios (HRs) for the highest vs lowest quartile were 1.70 (95% CI, 1.05-2.76) and 2.09 (1.27-3.44), respectively. Stronger associations were found for stroke. For both CVD and stroke, we found higher HRs across successive quartiles of BCAAs in the control group than in the MedDiet groups. With stroke as the outcome, a significant interaction (P = 0.009) between baseline BCAA score and intervention with MedDiet was observed. No significant effect of the intervention on 1-year changes in BCAAs or any association between 1-year changes in BCAAs and CVD were observed. CONCLUSIONSHigher concentrations of baseline BCAAs were associated with increased risk of CVD, especially stroke, in a high cardiovascular risk population. A Mediterranean-style diet had a negligible effect on 1-year changes in BCAAs, but it may counteract the harmful effects of BCAAs on stroke.
language: eng
source:
identifier: E-ISSN: 1530-8561 ; DOI: 1530-8561 ; DOI: 10.1373/clinchem.2015.251710
fulltext: fulltext
issn:
  • 15308561
  • 1530-8561
url: Link


@attributes
ID647443607
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1777078667
sourceidproquest
recordidTN_proquest1777078667
sourcesystemOther
pqid1777078667
galeid492735011
display
typearticle
titlePlasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial.
creatorRuiz-Canela, Miguel ; Toledo, Estefania ; Clish, Clary B ; Hruby, Adela ; Liang, Liming ; Salas-Salvadó, Jordi ; Razquin, Cristina ; Corella, Dolores ; Estruch, Ramón ; Ros, Emilio ; Fitó, Montserrat ; Gómez-Gracia, Enrique ; Arós, Fernando ; Fiol, Miquel ; Lapetra, José ; Serra-Majem, Lluis ; Martínez-González, Miguel A ; Hu, Frank B
contributorRuiz-Canela, Miguel (correspondence author) ; Ruiz-Canela, Miguel (record owner)
ispartofClinical chemistry, April 2016, Vol.62(4), pp.582-592
identifier
subject
descriptionBACKGROUNDThe role of branched-chain amino acids (BCAAs) in cardiovascular disease (CVD) remains poorly understood. We hypothesized that baseline BCAA concentrations predict future risk of CVD and that a Mediterranean diet (MedDiet) intervention may counteract this effect. METHODSWe developed a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED), with 226 incident CVD cases and 744 noncases. We used LC-MS/MS to measure plasma BCAAs (leucine, isoleucine, and valine), both at baseline and after 1 year of follow-up. The primary outcome was a composite of incident stroke, myocardial infarction, or cardiovascular death. RESULTSAfter adjustment for potential confounders, baseline leucine and isoleucine concentrations were associated with higher CVD risk: the hazard ratios (HRs) for the highest vs lowest quartile were 1.70 (95% CI, 1.05-2.76) and 2.09 (1.27-3.44), respectively. Stronger associations were found for stroke. For both CVD and stroke, we found higher HRs across successive quartiles of BCAAs in the control group than in the MedDiet groups. With stroke as the outcome, a significant interaction (P = 0.009) between baseline BCAA score and intervention with MedDiet was observed. No significant effect of the intervention on 1-year changes in BCAAs or any association between 1-year changes in BCAAs and CVD were observed. CONCLUSIONSHigher concentrations of baseline BCAAs were associated with increased risk of CVD, especially stroke, in a high cardiovascular risk population. A Mediterranean-style diet had a negligible effect on 1-year changes in BCAAs, but it may counteract the harmful effects of BCAAs on stroke.
languageeng
source
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1777078667/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Ruiz-Canela, Miguel
1Toledo, Estefania
2Clish, Clary B
3Hruby, Adela
4Liang, Liming
5Salas-Salvadó, Jordi
6Razquin, Cristina
7Corella, Dolores
8Estruch, Ramón
9Ros, Emilio
10Fitó, Montserrat
11Gómez-Gracia, Enrique
12Arós, Fernando
13Fiol, Miquel
14Lapetra, José
15Serra-Majem, Lluis
16Martínez-González, Miguel A
17Hu, Frank B
titlePlasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial.
descriptionBACKGROUNDThe role of branched-chain amino acids (BCAAs) in cardiovascular disease (CVD) remains poorly understood. We hypothesized that baseline BCAA concentrations predict future risk of CVD and that a Mediterranean diet (MedDiet) intervention may counteract this effect. METHODSWe developed a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED), with 226 incident CVD cases and 744 noncases. We used LC-MS/MS to measure plasma BCAAs (leucine, isoleucine, and valine), both at baseline and after 1 year of follow-up. The primary outcome was a composite of incident stroke, myocardial infarction, or cardiovascular death. RESULTSAfter adjustment for potential confounders, baseline leucine and isoleucine concentrations were associated with higher CVD risk: the hazard ratios (HRs) for the highest vs lowest quartile were 1.70 (95% CI, 1.05-2.76) and 2.09 (1.27-3.44), respectively. Stronger associations were found for stroke. For both CVD and stroke, we found higher HRs across successive quartiles of BCAAs in the control group than in the MedDiet groups. With stroke as the outcome, a significant interaction (P = 0.009) between baseline BCAA score and intervention with MedDiet was observed. No significant effect of the intervention on 1-year changes in BCAAs or any association between 1-year changes in BCAAs and CVD were observed. CONCLUSIONSHigher concentrations of baseline BCAAs were associated with increased risk of CVD, especially stroke, in a high cardiovascular risk population. A Mediterranean-style diet had a negligible effect on 1-year changes in BCAAs, but it may counteract the harmful effects of BCAAs on stroke.
subject
0Aged–Blood
1Amino Acids, Branched-Chain–Blood
2Cardiovascular Diseases–Diet Therapy
3Case-Control Studies–Epidemiology
4Cohort Studies–Statistics & Numerical Data
5Diet, Mediterranean–Statistics & Numerical Data
6Female–Statistics & Numerical Data
7Humans–Statistics & Numerical Data
8Incidence–Statistics & Numerical Data
9Male–Statistics & Numerical Data
10Multivariate Analysis–Statistics & Numerical Data
11Risk–Statistics & Numerical Data
12Amino Acids, Branched-Chain
general
0English
11530-8561
210.1373/clinchem.2015.251710
3MEDLINE (ProQuest)
4ProQuest Biological Science Collection
5ProQuest Natural Science Collection
6ProQuest SciTech Collection
7Biological Science Database
8Natural Science Collection
9SciTech Premium Collection
10Health Research Premium Collection
11Health Research Premium Collection (Alumni edition)
sourceidproquest
recordidproquest1777078667
issn
015308561
11530-8561
rsrctypearticle
creationdate2016
addtitleClinical chemistry
searchscope
01007527
11007944
210000004
310000038
410000050
510000120
610000159
710000238
810000253
910000260
1010000270
1110000271
1210000302
13proquest
scope
01007527
11007944
210000004
310000038
410000050
510000120
610000159
710000238
810000253
910000260
1010000270
1110000271
1210000302
13proquest
lsr43
01007527false
11007944false
210000004false
310000038false
410000050false
510000120false
610000159false
710000238false
810000253false
910000260false
1010000270false
1110000271false
1210000302false
contributorRuiz-Canela, Miguel
startdate20160401
enddate20160401
citationpf 582 pt 592 vol 62 issue 4
lsr30VSR-Enriched:[pqid, galeid, issn]
sort
titlePlasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial.
authorRuiz-Canela, Miguel ; Toledo, Estefania ; Clish, Clary B ; Hruby, Adela ; Liang, Liming ; Salas-Salvadó, Jordi ; Razquin, Cristina ; Corella, Dolores ; Estruch, Ramón ; Ros, Emilio ; Fitó, Montserrat ; Gómez-Gracia, Enrique ; Arós, Fernando ; Fiol, Miquel ; Lapetra, José ; Serra-Majem, Lluis ; Martínez-González, Miguel A ; Hu, Frank B
creationdate20160401
lso0120160401
facets
frbrgroupid-3526434212946381659
frbrtype5
newrecords20181218
languageeng
creationdate2016
topic
0Aged–Blood
1Amino Acids, Branched-Chain–Blood
2Cardiovascular Diseases–Diet Therapy
3Case-Control Studies–Epidemiology
4Cohort Studies–Statistics & Numerical Data
5Diet, Mediterranean–Statistics & Numerical Data
6Female–Statistics & Numerical Data
7Humans–Statistics & Numerical Data
8Incidence–Statistics & Numerical Data
9Male–Statistics & Numerical Data
10Multivariate Analysis–Statistics & Numerical Data
11Risk–Statistics & Numerical Data
12Amino Acids, Branched-Chain
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
prefilterarticles
rsrctypearticles
creatorcontrib
0Ruiz-Canela, Miguel
1Toledo, Estefania
2Clish, Clary B
3Hruby, Adela
4Liang, Liming
5Salas-Salvadó, Jordi
6Razquin, Cristina
7Corella, Dolores
8Estruch, Ramón
9Ros, Emilio
10Fitó, Montserrat
11Gómez-Gracia, Enrique
12Arós, Fernando
13Fiol, Miquel
14Lapetra, José
15Serra-Majem, Lluis
16Martínez-González, Miguel A
17Hu, Frank B
jtitleClinical chemistry
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Ruiz-Canela
1Toledo
2Clish
3Hruby
4Liang
5Salas-Salvadó
6Razquin
7Corella
8Estruch
9Ros
10Fitó
11Gómez-Gracia
12Arós
13Fiol
14Lapetra
15Serra-Majem
16Martínez-González
17Hu
aufirst
0Miguel
1Estefania
2Clary B
3Adela
4Liming
5Jordi
6Cristina
7Dolores
8Ramón
9Emilio
10Montserrat
11Enrique
12Fernando
13Miquel
14José
15Lluis
16Miguel A
17Frank B
au
0Ruiz-Canela, Miguel
1Toledo, Estefania
2Clish, Clary B
3Hruby, Adela
4Liang, Liming
5Salas-Salvadó, Jordi
6Razquin, Cristina
7Corella, Dolores
8Estruch, Ramón
9Ros, Emilio
10Fitó, Montserrat
11Gómez-Gracia, Enrique
12Arós, Fernando
13Fiol, Miquel
14Lapetra, José
15Serra-Majem, Lluis
16Martínez-González, Miguel A
17Hu, Frank B
addauRuiz-Canela, Miguel
atitlePlasma Branched-Chain Amino Acids and Incident Cardiovascular Disease in the PREDIMED Trial.
jtitleClinical chemistry
risdate20160401
volume62
issue4
spage582
epage592
pages582-592
eissn1530-8561
formatjournal
genrearticle
ristypeJOUR
abstractBACKGROUNDThe role of branched-chain amino acids (BCAAs) in cardiovascular disease (CVD) remains poorly understood. We hypothesized that baseline BCAA concentrations predict future risk of CVD and that a Mediterranean diet (MedDiet) intervention may counteract this effect. METHODSWe developed a case-cohort study within the Prevención con Dieta Mediterránea (PREDIMED), with 226 incident CVD cases and 744 noncases. We used LC-MS/MS to measure plasma BCAAs (leucine, isoleucine, and valine), both at baseline and after 1 year of follow-up. The primary outcome was a composite of incident stroke, myocardial infarction, or cardiovascular death. RESULTSAfter adjustment for potential confounders, baseline leucine and isoleucine concentrations were associated with higher CVD risk: the hazard ratios (HRs) for the highest vs lowest quartile were 1.70 (95% CI, 1.05-2.76) and 2.09 (1.27-3.44), respectively. Stronger associations were found for stroke. For both CVD and stroke, we found higher HRs across successive quartiles of BCAAs in the control group than in the MedDiet groups. With stroke as the outcome, a significant interaction (P = 0.009) between baseline BCAA score and intervention with MedDiet was observed. No significant effect of the intervention on 1-year changes in BCAAs or any association between 1-year changes in BCAAs and CVD were observed. CONCLUSIONSHigher concentrations of baseline BCAAs were associated with increased risk of CVD, especially stroke, in a high cardiovascular risk population. A Mediterranean-style diet had a negligible effect on 1-year changes in BCAAs, but it may counteract the harmful effects of BCAAs on stroke.
doi10.1373/clinchem.2015.251710
urlhttp://search.proquest.com/docview/1777078667/
issn00099147
date2016-04-01