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Reduced Expression of Galectin-9 Contributes to a Poor Outcome in Colon Cancer by Inhibiting NK Cell Chemotaxis Partially through the Rho/ROCK1 Signaling Pathway

Galectin-9 is a widely expressed protein that is involved in immune regulation and tumorpathogenesis and serves as a marker of a poor prognosis in various types of cancers. However, the clinical impact and the precise mechanism by which this protein contributes to colon tumor progression are unclear... Full description

Journal Title: PLoS One Mar 2016, Vol.11(3), p.e0152599
Main Author: Wang, Yang
Other Authors: Sun, Jintang , Ma, Chao , Gao, Wenjuan , Song, Bingfeng , Xue, Hao , Chen, Weiliang , Chen, Xi , Zhang, Yun , Shao, Qianqian , Wang, Qingjie , Zhao, Lei , Liu, Jia , Wang, Xiuwen , Wang, Huayang , Zhang, Yun , Yang, Meixiang , Qu, Xun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0152599
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title: Reduced Expression of Galectin-9 Contributes to a Poor Outcome in Colon Cancer by Inhibiting NK Cell Chemotaxis Partially through the Rho/ROCK1 Signaling Pathway
format: Article
creator:
  • Wang, Yang
  • Sun, Jintang
  • Ma, Chao
  • Gao, Wenjuan
  • Song, Bingfeng
  • Xue, Hao
  • Chen, Weiliang
  • Chen, Xi
  • Zhang, Yun
  • Shao, Qianqian
  • Wang, Qingjie
  • Zhao, Lei
  • Liu, Jia
  • Wang, Xiuwen
  • Wang, Huayang
  • Zhang, Yun
  • Yang, Meixiang
  • Qu, Xun
subjects:
  • Chemotaxis
  • Infiltration
  • Tumors
  • Quality
  • Cytoskeleton
  • Chemokines
  • Hazards
  • Infiltration
  • Immunoregulation
  • Cd56 Antigen
  • Galectin-9
  • Immunology
  • Hospitals
  • Regression Analysis
  • Pregnancy
  • Colon
  • Cell Migration
  • Tumors
  • Confocal Microscopy
  • Polarization
ispartof: PLoS One, Mar 2016, Vol.11(3), p.e0152599
description: Galectin-9 is a widely expressed protein that is involved in immune regulation and tumorpathogenesis and serves as a marker of a poor prognosis in various types of cancers. However, the clinical impact and the precise mechanism by which this protein contributes to colon tumor progression are unclear. In the present study, we detected the expression of galectin-9 and CD56 cells using immunohistochemistry. Spearman's rank correlation was used to clarify the association between galectin-9 expression and natural killer (NK) cell infiltration. The influence of galectin-9 on NK-92 cell migration was evaluated in vitro using transwell chemotaxis assays. The role of rh-galectin-9 in F-actin polarization in NK-92 cells was investigated using laser scanning confocal microscopy. We showed that galectin-9 was expressed in 101 (78.91%) colon tumor tissues and that was expressed at lower levels in these tissues than in para-tumor tissues. Low levels of galectin-9 expression were positively correlated...
language: eng
source:
identifier: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0152599
fulltext: fulltext_linktorsrc
issn:
  • 19326203
  • 1932-6203
url: Link


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titleReduced Expression of Galectin-9 Contributes to a Poor Outcome in Colon Cancer by Inhibiting NK Cell Chemotaxis Partially through the Rho/ROCK1 Signaling Pathway
creatorWang, Yang ; Sun, Jintang ; Ma, Chao ; Gao, Wenjuan ; Song, Bingfeng ; Xue, Hao ; Chen, Weiliang ; Chen, Xi ; Zhang, Yun ; Shao, Qianqian ; Wang, Qingjie ; Zhao, Lei ; Liu, Jia ; Wang, Xiuwen ; Wang, Huayang ; Zhang, Yun ; Yang, Meixiang ; Qu, Xun
ispartofPLoS One, Mar 2016, Vol.11(3), p.e0152599
identifierE-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0152599
subjectChemotaxis ; Infiltration ; Tumors ; Quality ; Cytoskeleton ; Chemokines ; Hazards ; Infiltration ; Immunoregulation ; Cd56 Antigen ; Galectin-9 ; Immunology ; Hospitals ; Regression Analysis ; Pregnancy ; Colon ; Cell Migration ; Tumors ; Confocal Microscopy ; Polarization
descriptionGalectin-9 is a widely expressed protein that is involved in immune regulation and tumorpathogenesis and serves as a marker of a poor prognosis in various types of cancers. However, the clinical impact and the precise mechanism by which this protein contributes to colon tumor progression are unclear. In the present study, we detected the expression of galectin-9 and CD56 cells using immunohistochemistry. Spearman's rank correlation was used to clarify the association between galectin-9 expression and natural killer (NK) cell infiltration. The influence of galectin-9 on NK-92 cell migration was evaluated in vitro using transwell chemotaxis assays. The role of rh-galectin-9 in F-actin polarization in NK-92 cells was investigated using laser scanning confocal microscopy. We showed that galectin-9 was expressed in 101 (78.91%) colon tumor tissues and that was expressed at lower levels in these tissues than in para-tumor tissues. Low levels of galectin-9 expression were positively correlated...
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titleReduced Expression of Galectin-9 Contributes to a Poor Outcome in Colon Cancer by Inhibiting NK Cell Chemotaxis Partially through the Rho/ROCK1 Signaling Pathway
descriptionGalectin-9 is a widely expressed protein that is involved in immune regulation and tumorpathogenesis and serves as a marker of a poor prognosis in various types of cancers. However, the clinical impact and the precise mechanism by which this protein contributes to colon tumor progression are unclear. In the present study, we detected the expression of galectin-9 and CD56 cells using immunohistochemistry. Spearman's rank correlation was used to clarify the association between galectin-9 expression and natural killer (NK) cell infiltration. The influence of galectin-9 on NK-92 cell migration was evaluated in vitro using transwell chemotaxis assays. The role of rh-galectin-9 in F-actin polarization in NK-92 cells was investigated using laser scanning confocal microscopy. We showed that galectin-9 was expressed in 101 (78.91%) colon tumor tissues and that was expressed at lower levels in these tissues than in para-tumor tissues. Low levels of galectin-9 expression were positively correlated...
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titleReduced Expression of Galectin-9 Contributes to a Poor Outcome in Colon Cancer by Inhibiting NK Cell Chemotaxis Partially through the Rho/ROCK1 Signaling Pathway
authorWang, Yang ; Sun, Jintang ; Ma, Chao ; Gao, Wenjuan ; Song, Bingfeng ; Xue, Hao ; Chen, Weiliang ; Chen, Xi ; Zhang, Yun ; Shao, Qianqian ; Wang, Qingjie ; Zhao, Lei ; Liu, Jia ; Wang, Xiuwen ; Wang, Huayang ; Zhang, Yun ; Yang, Meixiang ; Qu, Xun
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abstractGalectin-9 is a widely expressed protein that is involved in immune regulation and tumorpathogenesis and serves as a marker of a poor prognosis in various types of cancers. However, the clinical impact and the precise mechanism by which this protein contributes to colon tumor progression are unclear. In the present study, we detected the expression of galectin-9 and CD56 cells using immunohistochemistry. Spearman's rank correlation was used to clarify the association between galectin-9 expression and natural killer (NK) cell infiltration. The influence of galectin-9 on NK-92 cell migration was evaluated in vitro using transwell chemotaxis assays. The role of rh-galectin-9 in F-actin polarization in NK-92 cells was investigated using laser scanning confocal microscopy. We showed that galectin-9 was expressed in 101 (78.91%) colon tumor tissues and that was expressed at lower levels in these tissues than in para-tumor tissues. Low levels of galectin-9 expression were positively correlated...
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