schliessen

Filtern

 

Bibliotheken

Photoexcited quantum dots for killing multidrug-resistant bacteria.

Multidrug-resistant bacterial infections are an ever-growing threat because of the shrinking arsenal of efficacious antibiotics. Metal nanoparticles can induce cell death, yet the toxicity effect is typically nonspecific. Here, we show that photoexcited quantum dots (QDs) can kill a wide range of mu... Full description

Journal Title: Nature materials May 2016, Vol.15(5), pp.529-534
Main Author: Courtney, Colleen M
Other Authors: Goodman, Samuel M , Mcdaniel, Jessica A , Madinger, Nancy E , Chatterjee, Anushree , Nagpal, Prashant
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1476-1122 ; DOI: 10.1038/nmat4542
Link: http://search.proquest.com/docview/1784750082/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1784750082
title: Photoexcited quantum dots for killing multidrug-resistant bacteria.
format: Article
creator:
  • Courtney, Colleen M
  • Goodman, Samuel M
  • Mcdaniel, Jessica A
  • Madinger, Nancy E
  • Chatterjee, Anushree
  • Nagpal, Prashant
subjects:
  • Anti-Bacterial Agents–Chemistry
  • Bacteria–Pharmacology
  • Drug Resistance, Multiple, Bacterial–Metabolism
  • Oxidation-Reduction–Drug Effects
  • Quantum Dots–Drug Effects
  • Quantum Dots–Chemistry
  • Anti-Bacterial Agents
ispartof: Nature materials, May 2016, Vol.15(5), pp.529-534
description: Multidrug-resistant bacterial infections are an ever-growing threat because of the shrinking arsenal of efficacious antibiotics. Metal nanoparticles can induce cell death, yet the toxicity effect is typically nonspecific. Here, we show that photoexcited quantum dots (QDs) can kill a wide range of multidrug-resistant bacterial clinical isolates, including methicillin-resistant Staphylococcus aureus, carbapenem-resistant Escherichia coli, and extended-spectrum beta -lactamase-producing Klebsiella pneumoniae and Salmonella typhimurium. The killing effect is independent of material and controlled by the redox potentials of the photogenerated charge carriers, which selectively alter the cellular redox state. We also show that the QDs can be tailored to kill 92% of bacterial cells in a monoculture, and in a co-culture of E. coli and HEK 293T cells, while leaving the mammalian cells intact, or to increase bacterial proliferation. Photoexcited QDs could be used in the study of the effect of redox states on living systems, and lead to clinical phototherapy for the treatment of infections.
language: eng
source:
identifier: ISSN: 1476-1122 ; DOI: 10.1038/nmat4542
fulltext: fulltext
issn:
  • 14761122
  • 1476-1122
url: Link


@attributes
ID122234820
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1784750082
sourceidproquest
recordidTN_proquest1784750082
sourcesystemOther
pqid1784750082
display
typearticle
titlePhotoexcited quantum dots for killing multidrug-resistant bacteria.
creatorCourtney, Colleen M ; Goodman, Samuel M ; Mcdaniel, Jessica A ; Madinger, Nancy E ; Chatterjee, Anushree ; Nagpal, Prashant
contributorCourtney, Colleen M (correspondence author) ; Courtney, Colleen M (record owner)
ispartofNature materials, May 2016, Vol.15(5), pp.529-534
identifierISSN: 1476-1122 ; DOI: 10.1038/nmat4542
subjectAnti-Bacterial Agents–Chemistry ; Bacteria–Pharmacology ; Drug Resistance, Multiple, Bacterial–Metabolism ; Oxidation-Reduction–Drug Effects ; Quantum Dots–Drug Effects ; Quantum Dots–Chemistry ; Anti-Bacterial Agents
languageeng
source
descriptionMultidrug-resistant bacterial infections are an ever-growing threat because of the shrinking arsenal of efficacious antibiotics. Metal nanoparticles can induce cell death, yet the toxicity effect is typically nonspecific. Here, we show that photoexcited quantum dots (QDs) can kill a wide range of multidrug-resistant bacterial clinical isolates, including methicillin-resistant Staphylococcus aureus, carbapenem-resistant Escherichia coli, and extended-spectrum beta -lactamase-producing Klebsiella pneumoniae and Salmonella typhimurium. The killing effect is independent of material and controlled by the redox potentials of the photogenerated charge carriers, which selectively alter the cellular redox state. We also show that the QDs can be tailored to kill 92% of bacterial cells in a monoculture, and in a co-culture of E. coli and HEK 293T cells, while leaving the mammalian cells intact, or to increase bacterial proliferation. Photoexcited QDs could be used in the study of the effect of redox states on living systems, and lead to clinical phototherapy for the treatment of infections.
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1784750082/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Courtney, Colleen M
1Goodman, Samuel M
2Mcdaniel, Jessica A
3Madinger, Nancy E
4Chatterjee, Anushree
5Nagpal, Prashant
titlePhotoexcited quantum dots for killing multidrug-resistant bacteria.
subject
0Anti-Bacterial Agents–Chemistry
1Bacteria–Pharmacology
2Drug Resistance, Multiple, Bacterial–Metabolism
3Oxidation-Reduction–Drug Effects
4Quantum Dots–Drug Effects
5Quantum Dots–Chemistry
6Anti-Bacterial Agents
general
0English
110.1038/nmat4542
2MEDLINE (ProQuest)
3ProQuest Biological Science Collection
4ProQuest Environmental Science Collection
5ProQuest Natural Science Collection
6ProQuest SciTech Collection
7Agricultural & Environmental Science Database
8Biological Science Database
9Natural Science Collection
10SciTech Premium Collection
11Health Research Premium Collection
12Health Research Premium Collection (Alumni edition)
sourceidproquest
recordidproquest1784750082
issn
014761122
11476-1122
rsrctypearticle
creationdate2016
addtitleNature materials
searchscope
01007489
11007527
21007944
310000004
410000006
510000038
610000043
710000050
810000120
910000159
1010000198
1110000200
1210000209
1310000217
1410000234
1510000238
1610000253
1710000260
1810000270
1910000271
2010000302
21proquest
scope
01007489
11007527
21007944
310000004
410000006
510000038
610000043
710000050
810000120
910000159
1010000198
1110000200
1210000209
1310000217
1410000234
1510000238
1610000253
1710000260
1810000270
1910000271
2010000302
21proquest
lsr43
01007489false
11007527false
21007944false
310000004false
410000006false
510000038false
610000043false
710000050false
810000120false
910000159false
1010000198false
1110000200false
1210000209false
1310000217false
1410000234false
1510000238false
1610000253false
1710000260false
1810000270false
1910000271false
2010000302false
contributorCourtney, Colleen M
startdate20160501
enddate20160501
citationpf 529 pt 534 vol 15 issue 5
lsr30VSR-Enriched:[description, eissn, pqid]
sort
titlePhotoexcited quantum dots for killing multidrug-resistant bacteria.
authorCourtney, Colleen M ; Goodman, Samuel M ; Mcdaniel, Jessica A ; Madinger, Nancy E ; Chatterjee, Anushree ; Nagpal, Prashant
creationdate20160501
lso0120160501
facets
frbrgroupid5939970286241485079
frbrtype5
newrecords20181218
languageeng
creationdate2016
topic
0Anti-Bacterial Agents–Chemistry
1Bacteria–Pharmacology
2Drug Resistance, Multiple, Bacterial–Metabolism
3Oxidation-Reduction–Drug Effects
4Quantum Dots–Drug Effects
5Quantum Dots–Chemistry
6Anti-Bacterial Agents
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Environmental Science Collection
3ProQuest Natural Science Collection
4ProQuest SciTech Collection
5Agricultural & Environmental Science Database
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
prefilterarticles
rsrctypearticles
creatorcontrib
0Courtney, Colleen M
1Goodman, Samuel M
2Mcdaniel, Jessica A
3Madinger, Nancy E
4Chatterjee, Anushree
5Nagpal, Prashant
jtitleNature materials
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Courtney
1Goodman
2McDaniel
3Madinger
4Chatterjee
5Nagpal
aufirst
0Colleen M
1Samuel M
2Jessica A
3Nancy E
4Anushree
5Prashant
au
0Courtney, Colleen M
1Goodman, Samuel M
2Mcdaniel, Jessica A
3Madinger, Nancy E
4Chatterjee, Anushree
5Nagpal, Prashant
addauCourtney, Colleen M
atitlePhotoexcited quantum dots for killing multidrug-resistant bacteria.
jtitleNature materials
risdate20160501
volume15
issue5
spage529
epage534
pages529-534
issn1476-1122
formatjournal
genrearticle
ristypeJOUR
doi10.1038/nmat4542
urlhttp://search.proquest.com/docview/1784750082/
eissn14764660
date2016-05-01