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Asymmetric Reduction of alpha -Amino Ketones with a KBH sub(4) Solution Catalyzed by Chiral Lewis Acids

An efficient enantioselective reduction of alpha -amino ketones with potassium borohydride solution catalyzed by chiral N,N'-dioxide-metal complex catalysts was accomplished under mild reaction conditions for the first time. It provided a simple, convenient, and practical approaches for obtaining sy... Full description

Journal Title: Chemistry: A European Journal October 2014, Vol.20(42), pp.13482-13486
Main Author: He, Peng
Other Authors: Zheng, Haifeng , Liu, Xiaohua , Lian, Xiangjin , Lin, Lili , Feng, Xiaoming
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0947-6539 ; E-ISSN: 1521-3765 ; DOI: 10.1002/chem.201404732
Link: http://search.proquest.com/docview/1786189364/?pq-origsite=primo
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title: Asymmetric Reduction of alpha -Amino Ketones with a KBH sub(4) Solution Catalyzed by Chiral Lewis Acids
format: Article
creator:
  • He, Peng
  • Zheng, Haifeng
  • Liu, Xiaohua
  • Lian, Xiangjin
  • Lin, Lili
  • Feng, Xiaoming
subjects:
  • Reduction
  • Ketones
  • Alcohols
  • Chemical Reactions
  • Potassium
  • Borohydrides
  • Catalysts
  • Catalysis
  • Analysis (MD)
  • Chemical Analysis (Ep)
  • Chemical Analysis (Ed)
  • Chemical Analysis (EC)
ispartof: Chemistry: A European Journal, October 2014, Vol.20(42), pp.13482-13486
description: An efficient enantioselective reduction of alpha -amino ketones with potassium borohydride solution catalyzed by chiral N,N'-dioxide-metal complex catalysts was accomplished under mild reaction conditions for the first time. It provided a simple, convenient, and practical approaches for obtaining synthetically important chiral beta -amino alcohols in good to excellent yields (up to 98%) and enantioselectivities (up to 97%ee). An efficient reduction of alpha -amino ketones with potassium borohydride solution catalyzed by chiral N,N'-dioxide-metal complex catalysts was accomplished under mild reaction conditions for the first time. It provided a simple, convenient, and practical approach for obtaining synthetically important chiral beta -amino alcohols in good to excellent yields and enantioselectivities (see scheme).
language: eng
source:
identifier: ISSN: 0947-6539 ; E-ISSN: 1521-3765 ; DOI: 10.1002/chem.201404732
fulltext: fulltext
issn:
  • 09476539
  • 0947-6539
  • 15213765
  • 1521-3765
url: Link


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titleAsymmetric Reduction of alpha -Amino Ketones with a KBH sub(4) Solution Catalyzed by Chiral Lewis Acids
creatorHe, Peng ; Zheng, Haifeng ; Liu, Xiaohua ; Lian, Xiangjin ; Lin, Lili ; Feng, Xiaoming
contributorHe, Peng (correspondence author)
ispartofChemistry: A European Journal, October 2014, Vol.20(42), pp.13482-13486
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subjectReduction ; Ketones ; Alcohols ; Chemical Reactions ; Potassium ; Borohydrides ; Catalysts ; Catalysis ; Analysis (MD) ; Chemical Analysis (Ep) ; Chemical Analysis (Ed) ; Chemical Analysis (EC)
descriptionAn efficient enantioselective reduction of alpha -amino ketones with potassium borohydride solution catalyzed by chiral N,N'-dioxide-metal complex catalysts was accomplished under mild reaction conditions for the first time. It provided a simple, convenient, and practical approaches for obtaining synthetically important chiral beta -amino alcohols in good to excellent yields (up to 98%) and enantioselectivities (up to 97%ee). An efficient reduction of alpha -amino ketones with potassium borohydride solution catalyzed by chiral N,N'-dioxide-metal complex catalysts was accomplished under mild reaction conditions for the first time. It provided a simple, convenient, and practical approach for obtaining synthetically important chiral beta -amino alcohols in good to excellent yields and enantioselectivities (see scheme).
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titleAsymmetric Reduction of alpha -Amino Ketones with a KBH sub(4) Solution Catalyzed by Chiral Lewis Acids
descriptionAn efficient enantioselective reduction of alpha -amino ketones with potassium borohydride solution catalyzed by chiral N,N'-dioxide-metal complex catalysts was accomplished under mild reaction conditions for the first time. It provided a simple, convenient, and practical approaches for obtaining synthetically important chiral beta -amino alcohols in good to excellent yields (up to 98%) and enantioselectivities (up to 97%ee). An efficient reduction of alpha -amino ketones with potassium borohydride solution catalyzed by chiral N,N'-dioxide-metal complex catalysts was accomplished under mild reaction conditions for the first time. It provided a simple, convenient, and practical approach for obtaining synthetically important chiral beta -amino alcohols in good to excellent yields and enantioselectivities (see scheme).
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titleAsymmetric Reduction of alpha -Amino Ketones with a KBH sub(4) Solution Catalyzed by Chiral Lewis Acids
authorHe, Peng ; Zheng, Haifeng ; Liu, Xiaohua ; Lian, Xiangjin ; Lin, Lili ; Feng, Xiaoming
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abstractAn efficient enantioselective reduction of alpha -amino ketones with potassium borohydride solution catalyzed by chiral N,N'-dioxide-metal complex catalysts was accomplished under mild reaction conditions for the first time. It provided a simple, convenient, and practical approaches for obtaining synthetically important chiral beta -amino alcohols in good to excellent yields (up to 98%) and enantioselectivities (up to 97%ee). An efficient reduction of alpha -amino ketones with potassium borohydride solution catalyzed by chiral N,N'-dioxide-metal complex catalysts was accomplished under mild reaction conditions for the first time. It provided a simple, convenient, and practical approach for obtaining synthetically important chiral beta -amino alcohols in good to excellent yields and enantioselectivities (see scheme).
doi10.1002/chem.201404732
urlhttp://search.proquest.com/docview/1786189364/
date2014-10-13