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Strong and persistent effect on liver fat with a Paleolithic diet during a two-year intervention.

BACKGROUND/OBJECTIVESOur objective was to investigate changes in liver fat and insulin sensitivity during a 2-year diet intervention. An ad libitum Paleolithic diet (PD) was compared with a conventional low-fat diet (LFD). SUBJECTS/METHODSSeventy healthy, obese, postmenopausal women were randomized... Full description

Journal Title: International journal of obesity (2005) May 2016, Vol.40(5), pp.747-753
Main Author: Otten, J
Other Authors: Mellberg, C , Ryberg, M , Sandberg, S , Kullberg, J , Lindahl, B , Larsson, C , Hauksson, J , Olsson, T
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1476-5497 ; DOI: 10.1038/ijo.2016.4
Link: http://search.proquest.com/docview/1787093380/?pq-origsite=primo
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title: Strong and persistent effect on liver fat with a Paleolithic diet during a two-year intervention.
format: Article
creator:
  • Otten, J
  • Mellberg, C
  • Ryberg, M
  • Sandberg, S
  • Kullberg, J
  • Lindahl, B
  • Larsson, C
  • Hauksson, J
  • Olsson, T
subjects:
  • Blood Glucose–Drug Effects
  • Blood Pressure–Blood
  • Diet, Fat-Restricted–Drug Effects
  • Diet, Paleolithic–Pathology
  • Female–Diet Therapy
  • Glucose Tolerance Test–Etiology
  • Humans–Pathology
  • Insulin Resistance–Complications
  • Lipids–Diet Therapy
  • Liver–Pathology
  • Middle Aged–Pathology
  • Non-Alcoholic Fatty Liver Disease–Pathology
  • Obesity–Pathology
  • Postmenopause–Pathology
  • Sweden–Pathology
  • Time Factors–Pathology
  • Treatment Outcome–Pathology
  • Weight Loss–Pathology
  • Blood Glucose
  • Lipids
ispartof: International journal of obesity (2005), May 2016, Vol.40(5), pp.747-753
description: BACKGROUND/OBJECTIVESOur objective was to investigate changes in liver fat and insulin sensitivity during a 2-year diet intervention. An ad libitum Paleolithic diet (PD) was compared with a conventional low-fat diet (LFD). SUBJECTS/METHODSSeventy healthy, obese, postmenopausal women were randomized to either a PD or a conventional LFD. Diet intakes were ad libitum. Liver fat was measured with proton magnetic resonance spectroscopy. Insulin sensitivity was evaluated with oral glucose tolerance tests and calculated as homeostasis model assessment-insulin resistance (HOMA-IR)/liver insulin resistance (Liver IR) index for hepatic insulin sensitivity and oral glucose insulin sensitivity (OGIS)/Matsuda for peripheral insulin sensitivity. All measurements were performed at 0, 6 and 24 months. Forty-one women completed the examinations for liver fat and were included. RESULTSLiver fat decreased after 6 months by 64% (95% confidence interval: 54-74%) in the PD group and by 43% (27-59%) in the LFD...
language: eng
source:
identifier: E-ISSN: 1476-5497 ; DOI: 10.1038/ijo.2016.4
fulltext: fulltext
issn:
  • 14765497
  • 1476-5497
url: Link


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titleStrong and persistent effect on liver fat with a Paleolithic diet during a two-year intervention.
creatorOtten, J ; Mellberg, C ; Ryberg, M ; Sandberg, S ; Kullberg, J ; Lindahl, B ; Larsson, C ; Hauksson, J ; Olsson, T
contributorOtten, J (correspondence author) ; Otten, J (record owner)
ispartofInternational journal of obesity (2005), May 2016, Vol.40(5), pp.747-753
identifierE-ISSN: 1476-5497 ; DOI: 10.1038/ijo.2016.4
subjectBlood Glucose–Drug Effects ; Blood Pressure–Blood ; Diet, Fat-Restricted–Drug Effects ; Diet, Paleolithic–Pathology ; Female–Diet Therapy ; Glucose Tolerance Test–Etiology ; Humans–Pathology ; Insulin Resistance–Complications ; Lipids–Diet Therapy ; Liver–Pathology ; Middle Aged–Pathology ; Non-Alcoholic Fatty Liver Disease–Pathology ; Obesity–Pathology ; Postmenopause–Pathology ; Sweden–Pathology ; Time Factors–Pathology ; Treatment Outcome–Pathology ; Weight Loss–Pathology ; Blood Glucose ; Lipids
descriptionBACKGROUND/OBJECTIVESOur objective was to investigate changes in liver fat and insulin sensitivity during a 2-year diet intervention. An ad libitum Paleolithic diet (PD) was compared with a conventional low-fat diet (LFD). SUBJECTS/METHODSSeventy healthy, obese, postmenopausal women were randomized to either a PD or a conventional LFD. Diet intakes were ad libitum. Liver fat was measured with proton magnetic resonance spectroscopy. Insulin sensitivity was evaluated with oral glucose tolerance tests and calculated as homeostasis model assessment-insulin resistance (HOMA-IR)/liver insulin resistance (Liver IR) index for hepatic insulin sensitivity and oral glucose insulin sensitivity (OGIS)/Matsuda for peripheral insulin sensitivity. All measurements were performed at 0, 6 and 24 months. Forty-one women completed the examinations for liver fat and were included. RESULTSLiver fat decreased after 6 months by 64% (95% confidence interval: 54-74%) in the PD group and by 43% (27-59%) in the LFD...
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titleStrong and persistent effect on liver fat with a Paleolithic diet during a two-year intervention.
descriptionBACKGROUND/OBJECTIVESOur objective was to investigate changes in liver fat and insulin sensitivity during a 2-year diet intervention. An ad libitum Paleolithic diet (PD) was compared with a conventional low-fat diet (LFD). SUBJECTS/METHODSSeventy healthy, obese, postmenopausal women were randomized to either a PD or a conventional LFD. Diet intakes were ad libitum. Liver fat was measured with proton magnetic resonance spectroscopy. Insulin sensitivity was evaluated with oral glucose tolerance tests and calculated as homeostasis model assessment-insulin resistance (HOMA-IR)/liver insulin resistance (Liver IR) index for hepatic insulin sensitivity and oral glucose insulin sensitivity (OGIS)/Matsuda for peripheral insulin sensitivity. All measurements were performed at 0, 6 and 24 months. Forty-one women completed the examinations for liver fat and were included. RESULTSLiver fat decreased after 6 months by 64% (95% confidence interval: 54-74%) in the PD group and by 43% (27-59%) in the LFD...
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titleStrong and persistent effect on liver fat with a Paleolithic diet during a two-year intervention.
authorOtten, J ; Mellberg, C ; Ryberg, M ; Sandberg, S ; Kullberg, J ; Lindahl, B ; Larsson, C ; Hauksson, J ; Olsson, T
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11Non-Alcoholic Fatty Liver Disease–Pathology
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abstractBACKGROUND/OBJECTIVESOur objective was to investigate changes in liver fat and insulin sensitivity during a 2-year diet intervention. An ad libitum Paleolithic diet (PD) was compared with a conventional low-fat diet (LFD). SUBJECTS/METHODSSeventy healthy, obese, postmenopausal women were randomized to either a PD or a conventional LFD. Diet intakes were ad libitum. Liver fat was measured with proton magnetic resonance spectroscopy. Insulin sensitivity was evaluated with oral glucose tolerance tests and calculated as homeostasis model assessment-insulin resistance (HOMA-IR)/liver insulin resistance (Liver IR) index for hepatic insulin sensitivity and oral glucose insulin sensitivity (OGIS)/Matsuda for peripheral insulin sensitivity. All measurements were performed at 0, 6 and 24 months. Forty-one women completed the examinations for liver fat and were included. RESULTSLiver fat decreased after 6 months by 64% (95% confidence interval: 54-74%) in the PD group and by 43% (27-59%) in the LFD...
doi10.1038/ijo.2016.4
urlhttp://search.proquest.com/docview/1787093380/
issn03070565
date2016-05-01