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Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of Dendropanax morbifera Mediated by the Nrf2/HO-1 Pathway.

Dendropanax morbifera LEVEILLE (DP) has been used in traditional Korean medicines to treat a variety of inflammatory diseases. Although the in vitro anti-inflammatory potential of this plant is understood, its in vivo efficacy and underlying molecular mechanism of anti-inflammatory effects are large... Full description

Journal Title: Biological & pharmaceutical bulletin 2016, Vol.39(5), pp.728-736
Main Author: Akram, Muhammad
Other Authors: Kim, Kyeong-A , Kim, Eun-Sun , Syed, Ahmed Shah , Kim, Chul Young , Lee, Jong Soo , Bae, Ok-Nam
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1347-5215 ; DOI: 10.1248/bpb.b15-00823
Link: http://search.proquest.com/docview/1787471591/?pq-origsite=primo
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title: Potent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of Dendropanax morbifera Mediated by the Nrf2/HO-1 Pathway.
format: Article
creator:
  • Akram, Muhammad
  • Kim, Kyeong-A
  • Kim, Eun-Sun
  • Syed, Ahmed Shah
  • Kim, Chul Young
  • Lee, Jong Soo
  • Bae, Ok-Nam
subjects:
  • Acetic Acid–Pharmacology
  • Analgesics–Therapeutic Use
  • Animals–Pharmacology
  • Anti-Inflammatory Agents–Therapeutic Use
  • Araliaceae–Chemistry
  • Chloroform–Metabolism
  • Cytokines–Metabolism
  • Dinoprostone–Pathology
  • Ear–Chemically Induced
  • Edema–Drug Therapy
  • Heme Oxygenase-1–Metabolism
  • MAP Kinase Kinase 4–Metabolism
  • Male–Metabolism
  • Membrane Proteins–Metabolism
  • Mice–Metabolism
  • Mice, Inbred Icr–Metabolism
  • Nf-E2-Related Factor 2–Chemically Induced
  • Nf-Kappa B–Drug Therapy
  • Nitrites–Pharmacology
  • Pain–Therapeutic Use
  • Phytotherapy–Chemistry
  • Plant Extracts–Chemistry
  • Plant Leaves–Chemistry
  • Raw 264.7 Cells–Chemistry
  • Solvents–Chemistry
  • Tetradecanoylphorbol Acetate–Chemistry
  • Analgesics
  • Anti-Inflammatory Agents
  • Cytokines
  • Membrane Proteins
  • Nf-E2-Related Factor 2
  • Nf-Kappa B
  • Nitrites
  • Plant Extracts
  • Solvents
  • Chloroform
  • Heme Oxygenase-1
  • Hmox1 Protein, Mouse
  • MAP Kinase Kinase 4
  • Dinoprostone
  • Tetradecanoylphorbol Acetate
  • Acetic Acid
ispartof: Biological & pharmaceutical bulletin, 2016, Vol.39(5), pp.728-736
description: Dendropanax morbifera LEVEILLE (DP) has been used in traditional Korean medicines to treat a variety of inflammatory diseases. Although the in vitro anti-inflammatory potential of this plant is understood, its in vivo efficacy and underlying molecular mechanism of anti-inflammatory effects are largely unknown. We elucidated the anti-inflammatory and analgesic activities and the underlying molecular mechanisms of DP using in vitro and in vivo models. Lipopolysaccharide (LPS)-stimulated murine macrophages were used to analyze the in vitro anti-inflammatory potential of DP extract and to elucidate the underlying mechanisms. In vivo animal models of phorbol 12-myristate 13-acetate (TPA)-induced ear edema and acetic acid-induced writhing response tests were used to analyze the in vivo anti-inflammatory effects and anti-nociceptive effects of DP extract, respectively. Methanolic extract of DP (DPME) significantly inhibited the release of nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-activated macrophages. Among the five sub-fractions, the chloroform fraction (DP-C) showed the most potent suppressive effects against pro-inflammatory mediators and cytokines in LPS-stimulated macrophages. These effects were attributed to inhibition of nuclear factor-κB (NF-κB) nuclear translocation and c-Jun N terminal kinase (JNK) 1/2 phosphorylation and to activation of NF-E2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling. DP-C exhibited strong protective in vivo effects in TPA-induced ear edema mouse model and acetic acid-induced writhing response test. Our data suggest that DP-C has potent anti-inflammatory and analgesic activities and may be a promising treatment against a variety of inflammatory diseases.
language: eng
source:
identifier: E-ISSN: 1347-5215 ; DOI: 10.1248/bpb.b15-00823
fulltext: fulltext
issn:
  • 13475215
  • 1347-5215
url: Link


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titlePotent Anti-inflammatory and Analgesic Actions of the Chloroform Extract of Dendropanax morbifera Mediated by the Nrf2/HO-1 Pathway.
creatorAkram, Muhammad ; Kim, Kyeong-A ; Kim, Eun-Sun ; Syed, Ahmed Shah ; Kim, Chul Young ; Lee, Jong Soo ; Bae, Ok-Nam
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identifierE-ISSN: 1347-5215 ; DOI: 10.1248/bpb.b15-00823
subjectAcetic Acid–Pharmacology ; Analgesics–Therapeutic Use ; Animals–Pharmacology ; Anti-Inflammatory Agents–Therapeutic Use ; Araliaceae–Chemistry ; Chloroform–Metabolism ; Cytokines–Metabolism ; Dinoprostone–Pathology ; Ear–Chemically Induced ; Edema–Drug Therapy ; Heme Oxygenase-1–Metabolism ; MAP Kinase Kinase 4–Metabolism ; Male–Metabolism ; Membrane Proteins–Metabolism ; Mice–Metabolism ; Mice, Inbred Icr–Metabolism ; Nf-E2-Related Factor 2–Chemically Induced ; Nf-Kappa B–Drug Therapy ; Nitrites–Pharmacology ; Pain–Therapeutic Use ; Phytotherapy–Chemistry ; Plant Extracts–Chemistry ; Plant Leaves–Chemistry ; Raw 264.7 Cells–Chemistry ; Solvents–Chemistry ; Tetradecanoylphorbol Acetate–Chemistry ; Analgesics ; Anti-Inflammatory Agents ; Cytokines ; Membrane Proteins ; Nf-E2-Related Factor 2 ; Nf-Kappa B ; Nitrites ; Plant Extracts ; Solvents ; Chloroform ; Heme Oxygenase-1 ; Hmox1 Protein, Mouse ; MAP Kinase Kinase 4 ; Dinoprostone ; Tetradecanoylphorbol Acetate ; Acetic Acid
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