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Residual Human Immunodeficiency Virus (HIV) Type 1 RNA and DNA in Lymph Nodes and HIV RNA in Genital Secretions and in Cerebrospinal Fluid after Suppression of Viremia for 2 Years

Residual viral replication persists in a significant proportion of human immunodeficiency virus (HIV)-infected patients receiving potent antiretroviral therapy. To determine the source of this virus, levels of HIV RNA and DNA from lymphoid tissues and levels of viral RNA in serum, cerebrospinal flui... Full description

Journal Title: Journal of Infectious Diseases May 1, 2001, Vol.183(9), pp.1318-1327
Main Author: Guenthard, H
Other Authors: Havlir, D , Fiscus, S , Zhang, Zhi-Qiang , Eron, J , Mellors, J , Gulick, R , Frost, Sdw , Brown, Ajl , Schleif, W , Valentine, F , Jonas, L , Meibohm, A , Ignacio, C
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 0022-1899
Link: http://search.proquest.com/docview/17899761/
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title: Residual Human Immunodeficiency Virus (HIV) Type 1 RNA and DNA in Lymph Nodes and HIV RNA in Genital Secretions and in Cerebrospinal Fluid after Suppression of Viremia for 2 Years
format: Article
creator:
  • Guenthard, H
  • Havlir, D
  • Fiscus, S
  • Zhang, Zhi-Qiang
  • Eron, J
  • Mellors, J
  • Gulick, R
  • Frost, Sdw
  • Brown, Ajl
  • Schleif, W
  • Valentine, F
  • Jonas, L
  • Meibohm, A
  • Ignacio, C
subjects:
  • Human Immunodeficiency Virus 1
  • Acquired Immune Deficiency Syndrome
  • Viremia
  • Cerebrospinal Fluid
  • Lymph Nodes
  • Indinavir
  • Zidovudine
  • Lamivudine
  • Genitourinary Tract
  • AIDS: Clinical Aspects
  • HIV-1
  • HIV-1
ispartof: Journal of Infectious Diseases, May 1, 2001, Vol.183(9), pp.1318-1327
description: Residual viral replication persists in a significant proportion of human immunodeficiency virus (HIV)-infected patients receiving potent antiretroviral therapy. To determine the source of this virus, levels of HIV RNA and DNA from lymphoid tissues and levels of viral RNA in serum, cerebrospinal fluid (CSF), and genital secretions in 28 patients treated for less than or equal to 2.5 years with indinavir, zidovudine, and lamivudine were examined. Both HIV RNA and DNA remained detectable in all lymph nodes. In contrast, HIV RNA was not detected in 20 of 23 genital secretions or in any of 13 CSF samples after 2 years of treatment. HIV envelope sequence data from plasma and lymph nodes from 4 patients demonstrated sequence divergence, which suggests varying degrees of residual viral replication in 3 and absence in 1 patient. In patients receiving potent antiretroviral therapy, the greatest virus burden may continue to be in lymphoid tissues rather than in central nervous system or genitourinary compartments.
language: eng
source:
identifier: ISSN: 0022-1899
fulltext: fulltext
issn:
  • 00221899
  • 0022-1899
url: Link


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titleResidual Human Immunodeficiency Virus (HIV) Type 1 RNA and DNA in Lymph Nodes and HIV RNA in Genital Secretions and in Cerebrospinal Fluid after Suppression of Viremia for 2 Years
creatorGuenthard, H ; Havlir, D ; Fiscus, S ; Zhang, Zhi-Qiang ; Eron, J ; Mellors, J ; Gulick, R ; Frost, Sdw ; Brown, Ajl ; Schleif, W ; Valentine, F ; Jonas, L ; Meibohm, A ; Ignacio, C
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ispartofJournal of Infectious Diseases, May 1, 2001, Vol.183(9), pp.1318-1327
identifierISSN: 0022-1899
subjectHuman Immunodeficiency Virus 1 ; Acquired Immune Deficiency Syndrome ; Viremia ; Cerebrospinal Fluid ; Lymph Nodes ; Indinavir ; Zidovudine ; Lamivudine ; Genitourinary Tract ; AIDS: Clinical Aspects ; HIV-1 ; HIV-1
descriptionResidual viral replication persists in a significant proportion of human immunodeficiency virus (HIV)-infected patients receiving potent antiretroviral therapy. To determine the source of this virus, levels of HIV RNA and DNA from lymphoid tissues and levels of viral RNA in serum, cerebrospinal fluid (CSF), and genital secretions in 28 patients treated for less than or equal to 2.5 years with indinavir, zidovudine, and lamivudine were examined. Both HIV RNA and DNA remained detectable in all lymph nodes. In contrast, HIV RNA was not detected in 20 of 23 genital secretions or in any of 13 CSF samples after 2 years of treatment. HIV envelope sequence data from plasma and lymph nodes from 4 patients demonstrated sequence divergence, which suggests varying degrees of residual viral replication in 3 and absence in 1 patient. In patients receiving potent antiretroviral therapy, the greatest virus burden may continue to be in lymphoid tissues rather than in central nervous system or genitourinary compartments.
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titleResidual Human Immunodeficiency Virus (HIV) Type 1 RNA and DNA in Lymph Nodes and HIV RNA in Genital Secretions and in Cerebrospinal Fluid after Suppression of Viremia for 2 Years
descriptionResidual viral replication persists in a significant proportion of human immunodeficiency virus (HIV)-infected patients receiving potent antiretroviral therapy. To determine the source of this virus, levels of HIV RNA and DNA from lymphoid tissues and levels of viral RNA in serum, cerebrospinal fluid (CSF), and genital secretions in 28 patients treated for less than or equal to 2.5 years with indinavir, zidovudine, and lamivudine were examined. Both HIV RNA and DNA remained detectable in all lymph nodes. In contrast, HIV RNA was not detected in 20 of 23 genital secretions or in any of 13 CSF samples after 2 years of treatment. HIV envelope sequence data from plasma and lymph nodes from 4 patients demonstrated sequence divergence, which suggests varying degrees of residual viral replication in 3 and absence in 1 patient. In patients receiving potent antiretroviral therapy, the greatest virus burden may continue to be in lymphoid tissues rather than in central nervous system or genitourinary compartments.
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abstractResidual viral replication persists in a significant proportion of human immunodeficiency virus (HIV)-infected patients receiving potent antiretroviral therapy. To determine the source of this virus, levels of HIV RNA and DNA from lymphoid tissues and levels of viral RNA in serum, cerebrospinal fluid (CSF), and genital secretions in 28 patients treated for less than or equal to 2.5 years with indinavir, zidovudine, and lamivudine were examined. Both HIV RNA and DNA remained detectable in all lymph nodes. In contrast, HIV RNA was not detected in 20 of 23 genital secretions or in any of 13 CSF samples after 2 years of treatment. HIV envelope sequence data from plasma and lymph nodes from 4 patients demonstrated sequence divergence, which suggests varying degrees of residual viral replication in 3 and absence in 1 patient. In patients receiving potent antiretroviral therapy, the greatest virus burden may continue to be in lymphoid tissues rather than in central nervous system or genitourinary compartments.
urlhttp://search.proquest.com/docview/17899761/
doi10.1086/319864
eissn15376613
date2001-05-01