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Lymph nodes regression grade is a predictive marker for rectal cancer after neoadjuvant therapy and radical surgery.

Neoadjuvant therapy (NT) for rectal cancer (RC) reduces primary tumors and involved lymph nodes. While a prognostic value of tumor regression grade (TRG) has been identified, involved lymph node regression grade (LRG) has not been systematically evaluated. Here, we evaluated the association of LRG w... Full description

Journal Title: Oncotarget March 29, 2016, Vol.7(13), pp.16975-16984
Main Author: Li, Jun
Other Authors: Yuan, Jiatian , Liu, Hao , Yin, Jie , Liu, Sai , Du, Feng , Hu, Junjie , Li, Ci , Niu, Xiangke , Lv, Bo , Xing, Shasha
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.7703
Link: http://search.proquest.com/docview/1791325997/?pq-origsite=primo
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recordid: proquest1791325997
title: Lymph nodes regression grade is a predictive marker for rectal cancer after neoadjuvant therapy and radical surgery.
format: Article
creator:
  • Li, Jun
  • Yuan, Jiatian
  • Liu, Hao
  • Yin, Jie
  • Liu, Sai
  • Du, Feng
  • Hu, Junjie
  • Li, Ci
  • Niu, Xiangke
  • Lv, Bo
  • Xing, Shasha
subjects:
  • Adult–Methods
  • Aged–Methods
  • Chemoradiotherapy–Pathology
  • Combined Modality Therapy–Methods
  • Digestive System Surgical Procedures–Mortality
  • Disease-Free Survival–Pathology
  • Female–Therapy
  • Humans–Therapy
  • Kaplan-Meier Estimate–Therapy
  • Lymphatic Metastasis–Therapy
  • Male–Therapy
  • Middle Aged–Therapy
  • Neoadjuvant Therapy–Therapy
  • Neoplasm Grading–Therapy
  • Neoplasm Staging–Therapy
  • Prognosis–Therapy
  • Rectal Neoplasms–Therapy
  • Retrospective Studies–Therapy
  • Lymph Node
  • Neoadjuvant Therapy
  • Rectal Cancer
  • Regression Grading
ispartof: Oncotarget, March 29, 2016, Vol.7(13), pp.16975-16984
description: Neoadjuvant therapy (NT) for rectal cancer (RC) reduces primary tumors and involved lymph nodes. While a prognostic value of tumor regression grade (TRG) has been identified, involved lymph node regression grade (LRG) has not been systematically evaluated. Here, we evaluated the association of LRG with oncologic outcomes of RC patients after NT followed by radical surgery. 347 patients with locally advanced RC who received NT and then underwent radical surgery were retrospectively recruited between 2004 and 2011. Response to NT was evaluated by a 3-tier LRG and TRG based on the ratio of residual tumor to fibrosis. LRG was assessed in all patients (LRG 0, 170 patients [49.0%]; LRG 1, 100 patients [28.8%]; and LRG 2, 77 patients [22.2%]). LRG correlated with 5-year distant metastasis and 5-year disease free survival (p=0.029 and 0.023, respectively). LRG also correlated with TRG (p=0.017). We conclude that the LRG system may be an independent predictive factor of long-term oncologic outcomes...
language: eng
source:
identifier: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.7703
fulltext: fulltext
issn:
  • 19492553
  • 1949-2553
url: Link


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titleLymph nodes regression grade is a predictive marker for rectal cancer after neoadjuvant therapy and radical surgery.
creatorLi, Jun ; Yuan, Jiatian ; Liu, Hao ; Yin, Jie ; Liu, Sai ; Du, Feng ; Hu, Junjie ; Li, Ci ; Niu, Xiangke ; Lv, Bo ; Xing, Shasha
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ispartofOncotarget, March 29, 2016, Vol.7(13), pp.16975-16984
identifierE-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.7703
subjectAdult–Methods ; Aged–Methods ; Chemoradiotherapy–Pathology ; Combined Modality Therapy–Methods ; Digestive System Surgical Procedures–Mortality ; Disease-Free Survival–Pathology ; Female–Therapy ; Humans–Therapy ; Kaplan-Meier Estimate–Therapy ; Lymphatic Metastasis–Therapy ; Male–Therapy ; Middle Aged–Therapy ; Neoadjuvant Therapy–Therapy ; Neoplasm Grading–Therapy ; Neoplasm Staging–Therapy ; Prognosis–Therapy ; Rectal Neoplasms–Therapy ; Retrospective Studies–Therapy ; Lymph Node ; Neoadjuvant Therapy ; Rectal Cancer ; Regression Grading
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descriptionNeoadjuvant therapy (NT) for rectal cancer (RC) reduces primary tumors and involved lymph nodes. While a prognostic value of tumor regression grade (TRG) has been identified, involved lymph node regression grade (LRG) has not been systematically evaluated. Here, we evaluated the association of LRG with oncologic outcomes of RC patients after NT followed by radical surgery. 347 patients with locally advanced RC who received NT and then underwent radical surgery were retrospectively recruited between 2004 and 2011. Response to NT was evaluated by a 3-tier LRG and TRG based on the ratio of residual tumor to fibrosis. LRG was assessed in all patients (LRG 0, 170 patients [49.0%]; LRG 1, 100 patients [28.8%]; and LRG 2, 77 patients [22.2%]). LRG correlated with 5-year distant metastasis and 5-year disease free survival (p=0.029 and 0.023, respectively). LRG also correlated with TRG (p=0.017). We conclude that the LRG system may be an independent predictive factor of long-term oncologic outcomes...
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