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Escitalopram Decreases Cross-Regional Functional Connectivity within the Default-Mode Network.

The default-mode network (DMN), which comprises medial frontal, temporal and parietal regions, is part of the brain’s intrinsic organization. The serotonergic (5-HT) neurotransmitter system projects to DMN regions from midbrain efferents, and manipulation of this system could thus reveal insights in... Full description

Journal Title: PloS one 2013, Vol.8(6), p.e68355
Main Author: van de Ven, Vincent
Other Authors: Wingen, Marleen , Kuypers, Kim P C , Ramaekers, Johannes G , Formisano, Elia
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0068355
Link: http://search.proquest.com/docview/1791719092/?pq-origsite=primo
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recordid: proquest1791719092
title: Escitalopram Decreases Cross-Regional Functional Connectivity within the Default-Mode Network.
format: Article
creator:
  • van de Ven, Vincent
  • Wingen, Marleen
  • Kuypers, Kim P C
  • Ramaekers, Johannes G
  • Formisano, Elia
subjects:
  • Adult–Diagnostic Imaging
  • Brain–Drug Effects
  • Brain Mapping–Physiology
  • Citalopram–Pharmacology
  • Cross-Over Studies–Diagnostic Imaging
  • Double-Blind Method–Drug Effects
  • Female–Physiology
  • Humans–Metabolism
  • Magnetic Resonance Imaging–Pharmacology
  • Male–Pharmacology
  • Neural Pathways–Pharmacology
  • Rest–Pharmacology
  • Serotonin–Pharmacology
  • Serotonin Uptake Inhibitors–Pharmacology
  • Serotonin Uptake Inhibitors
  • Citalopram
  • Serotonin
ispartof: PloS one, 2013, Vol.8(6), p.e68355
description: The default-mode network (DMN), which comprises medial frontal, temporal and parietal regions, is part of the brain’s intrinsic organization. The serotonergic (5-HT) neurotransmitter system projects to DMN regions from midbrain efferents, and manipulation of this system could thus reveal insights into the neurobiological mechanisms of DMN functioning. Here, we investigate intrinsic functional connectivity of the DMN as a function of activity of the serotonergic system, through the administration of the selective serotonin reuptake inhibitor (SSRI) escitalopram. We quantified DMN functional connectivity using an approach based on dual-regression. Specifically, we decomposed group data of a subset of the functional time series using spatial independent component analysis, and projected the group spatial modes to the same and an independent resting state time series of individual participants. We found no effects of escitalopram on global functional connectivity of the DMN at the map-level; that is, escitalopram did not alter the global functional architecture of the DMN. However, we found that escitalopram decreased DMN regional pairwise connectivity, which included anterior and posterior cingulate cortex, hippocampal complex and lateral parietal regions. Further, regional DMN connectivity covaried with alertness ratings across participants. Our findings show that escitalopram altered intrinsic regional DMN connectivity, which suggests that the serotonergic system plays an important role in DMN connectivity and its contribution to cognition. Pharmacological challenge designs may be a useful addition to resting-state functional MRI to investigate intrinsic brain functional organization.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0068355
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleEscitalopram Decreases Cross-Regional Functional Connectivity within the Default-Mode Network.
creatorvan de Ven, Vincent ; Wingen, Marleen ; Kuypers, Kim P C ; Ramaekers, Johannes G ; Formisano, Elia
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ispartofPloS one, 2013, Vol.8(6), p.e68355
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0068355
subjectAdult–Diagnostic Imaging ; Brain–Drug Effects ; Brain Mapping–Physiology ; Citalopram–Pharmacology ; Cross-Over Studies–Diagnostic Imaging ; Double-Blind Method–Drug Effects ; Female–Physiology ; Humans–Metabolism ; Magnetic Resonance Imaging–Pharmacology ; Male–Pharmacology ; Neural Pathways–Pharmacology ; Rest–Pharmacology ; Serotonin–Pharmacology ; Serotonin Uptake Inhibitors–Pharmacology ; Serotonin Uptake Inhibitors ; Citalopram ; Serotonin
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descriptionThe default-mode network (DMN), which comprises medial frontal, temporal and parietal regions, is part of the brain’s intrinsic organization. The serotonergic (5-HT) neurotransmitter system projects to DMN regions from midbrain efferents, and manipulation of this system could thus reveal insights into the neurobiological mechanisms of DMN functioning. Here, we investigate intrinsic functional connectivity of the DMN as a function of activity of the serotonergic system, through the administration of the selective serotonin reuptake inhibitor (SSRI) escitalopram. We quantified DMN functional connectivity using an approach based on dual-regression. Specifically, we decomposed group data of a subset of the functional time series using spatial independent component analysis, and projected the group spatial modes to the same and an independent resting state time series of individual participants. We found no effects of escitalopram on global functional connectivity of the DMN at the map-level; that is, escitalopram did not alter the global functional architecture of the DMN. However, we found that escitalopram decreased DMN regional pairwise connectivity, which included anterior and posterior cingulate cortex, hippocampal complex and lateral parietal regions. Further, regional DMN connectivity covaried with alertness ratings across participants. Our findings show that escitalopram altered intrinsic regional DMN connectivity, which suggests that the serotonergic system plays an important role in DMN connectivity and its contribution to cognition. Pharmacological challenge designs may be a useful addition to resting-state functional MRI to investigate intrinsic brain functional organization.
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