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COAXIAL ELECTROSPINNING OF FIBERS AS A PROCESS TO ENCAPSULATE ANTISEPTIC DRUGS

Aim: The first step in wound healing is to clear the area using antiseptic and/or antimicrobial agents. Benzoin can be used as a model antiseptic agent encapsulated into a drug delivery carrier. Electrospinning (E-Spin) has been acknowledged as a versatile technique for the production of fibers to e... Full description

Journal Title: International Journal of Artificial Organs 0, 2014, Vol.37(8), p.641
Main Author: Repanas, A
Other Authors: Zernetsch, H , Glasmacher, B
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0391-3988 ; DOI: 10.5301/ijao.5000347
Link: http://search.proquest.com/docview/1793288499/?pq-origsite=primo
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title: COAXIAL ELECTROSPINNING OF FIBERS AS A PROCESS TO ENCAPSULATE ANTISEPTIC DRUGS
format: Article
creator:
  • Repanas, A
  • Zernetsch, H
  • Glasmacher, B
subjects:
  • Fibers
  • Electrospinning
  • Carriers
  • Antiseptics
  • Wound Healing
  • Drug Delivery Systems
  • Drugs
  • Encapsulation
  • Engineering and Industry (So)
  • Design Principles (Mt)
  • Engineering Components and Structures (MD)
  • Engineering Components and Structures (Ep)
  • Engineering Components and Structures (Ed)
  • Engineering Components and Structures (EC)
  • (An)
ispartof: International Journal of Artificial Organs, 0, 2014, Vol.37(8), p.641
description: Aim: The first step in wound healing is to clear the area using antiseptic and/or antimicrobial agents. Benzoin can be used as a model antiseptic agent encapsulated into a drug delivery carrier. Electrospinning (E-Spin) has been acknowledged as a versatile technique for the production of fibers to encapsulate therapeutics. Methods: Both single jet and coaxial jet E-Spin were used as a method to produce fibers. Polycaprolactone (PCL) and Benzoin (BZ) were dissolved in 99,8 Vol.% 2,2,2-Trifluoroethanol (TFE) at concentrations of 170 mg/mL and 17 mg/mL respectively for the single jet E-Spin. For the coaxial jet E-Spin the same solution was used for the core while a 50 mg/mL solution of Poly-lactic acid (PLA) in the same solvent was used for the sheath. Morphology of the fibrous scaffolds as well as fiber diameter and pore size were examined by Scanning Electron Microscopy (SEM). Samples of defined dimensions were incubated in an acetate buffer resembling skin pH at 37[degrees]C inside a water bath and the absorbance was measured by using a UV-Vis spectrophotometer to evaluate the cumulative release of BZ and investigate the release mechanism. Results: The coaxial approach resulted in fibers with an average diameter of 1.83 mu m and an average pore size of 16.11 mu m super(2). Furthermore, the release time prolonged for 7 days; the amount of drug released in the first 8 hours was reduced from 65.1% to 11.65% and the encapsulation efficiency increased from 87.5% to 97.1% in contrast to single jet electrospun fibers, following a Fickian diffusion. Conclusions: Core-shell fibers with the antiseptic agent inside the core can be considered as drug delivery carriers for sustained release in wound healing applications in clinical practice.
language: eng
source:
identifier: ISSN: 0391-3988 ; DOI: 10.5301/ijao.5000347
fulltext: no_fulltext
issn:
  • 03913988
  • 0391-3988
url: Link


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titleCOAXIAL ELECTROSPINNING OF FIBERS AS A PROCESS TO ENCAPSULATE ANTISEPTIC DRUGS
creatorRepanas, A ; Zernetsch, H ; Glasmacher, B
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ispartofInternational Journal of Artificial Organs, 0, 2014, Vol.37(8), p.641
identifierISSN: 0391-3988 ; DOI: 10.5301/ijao.5000347
subjectFibers ; Electrospinning ; Carriers ; Antiseptics ; Wound Healing ; Drug Delivery Systems ; Drugs ; Encapsulation ; Engineering and Industry (So) ; Design Principles (Mt) ; Engineering Components and Structures (MD) ; Engineering Components and Structures (Ep) ; Engineering Components and Structures (Ed) ; Engineering Components and Structures (EC) ; (An)
descriptionAim: The first step in wound healing is to clear the area using antiseptic and/or antimicrobial agents. Benzoin can be used as a model antiseptic agent encapsulated into a drug delivery carrier. Electrospinning (E-Spin) has been acknowledged as a versatile technique for the production of fibers to encapsulate therapeutics. Methods: Both single jet and coaxial jet E-Spin were used as a method to produce fibers. Polycaprolactone (PCL) and Benzoin (BZ) were dissolved in 99,8 Vol.% 2,2,2-Trifluoroethanol (TFE) at concentrations of 170 mg/mL and 17 mg/mL respectively for the single jet E-Spin. For the coaxial jet E-Spin the same solution was used for the core while a 50 mg/mL solution of Poly-lactic acid (PLA) in the same solvent was used for the sheath. Morphology of the fibrous scaffolds as well as fiber diameter and pore size were examined by Scanning Electron Microscopy (SEM). Samples of defined dimensions were incubated in an acetate buffer resembling skin pH at 37[degrees]C inside a water bath and the absorbance was measured by using a UV-Vis spectrophotometer to evaluate the cumulative release of BZ and investigate the release mechanism. Results: The coaxial approach resulted in fibers with an average diameter of 1.83 mu m and an average pore size of 16.11 mu m super(2). Furthermore, the release time prolonged for 7 days; the amount of drug released in the first 8 hours was reduced from 65.1% to 11.65% and the encapsulation efficiency increased from 87.5% to 97.1% in contrast to single jet electrospun fibers, following a Fickian diffusion. Conclusions: Core-shell fibers with the antiseptic agent inside the core can be considered as drug delivery carriers for sustained release in wound healing applications in clinical practice.
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descriptionAim: The first step in wound healing is to clear the area using antiseptic and/or antimicrobial agents. Benzoin can be used as a model antiseptic agent encapsulated into a drug delivery carrier. Electrospinning (E-Spin) has been acknowledged as a versatile technique for the production of fibers to encapsulate therapeutics. Methods: Both single jet and coaxial jet E-Spin were used as a method to produce fibers. Polycaprolactone (PCL) and Benzoin (BZ) were dissolved in 99,8 Vol.% 2,2,2-Trifluoroethanol (TFE) at concentrations of 170 mg/mL and 17 mg/mL respectively for the single jet E-Spin. For the coaxial jet E-Spin the same solution was used for the core while a 50 mg/mL solution of Poly-lactic acid (PLA) in the same solvent was used for the sheath. Morphology of the fibrous scaffolds as well as fiber diameter and pore size were examined by Scanning Electron Microscopy (SEM). Samples of defined dimensions were incubated in an acetate buffer resembling skin pH at 37[degrees]C inside a water bath and the absorbance was measured by using a UV-Vis spectrophotometer to evaluate the cumulative release of BZ and investigate the release mechanism. Results: The coaxial approach resulted in fibers with an average diameter of 1.83 mu m and an average pore size of 16.11 mu m super(2). Furthermore, the release time prolonged for 7 days; the amount of drug released in the first 8 hours was reduced from 65.1% to 11.65% and the encapsulation efficiency increased from 87.5% to 97.1% in contrast to single jet electrospun fibers, following a Fickian diffusion. Conclusions: Core-shell fibers with the antiseptic agent inside the core can be considered as drug delivery carriers for sustained release in wound healing applications in clinical practice.
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titleCOAXIAL ELECTROSPINNING OF FIBERS AS A PROCESS TO ENCAPSULATE ANTISEPTIC DRUGS
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abstractAim: The first step in wound healing is to clear the area using antiseptic and/or antimicrobial agents. Benzoin can be used as a model antiseptic agent encapsulated into a drug delivery carrier. Electrospinning (E-Spin) has been acknowledged as a versatile technique for the production of fibers to encapsulate therapeutics. Methods: Both single jet and coaxial jet E-Spin were used as a method to produce fibers. Polycaprolactone (PCL) and Benzoin (BZ) were dissolved in 99,8 Vol.% 2,2,2-Trifluoroethanol (TFE) at concentrations of 170 mg/mL and 17 mg/mL respectively for the single jet E-Spin. For the coaxial jet E-Spin the same solution was used for the core while a 50 mg/mL solution of Poly-lactic acid (PLA) in the same solvent was used for the sheath. Morphology of the fibrous scaffolds as well as fiber diameter and pore size were examined by Scanning Electron Microscopy (SEM). Samples of defined dimensions were incubated in an acetate buffer resembling skin pH at 37[degrees]C inside a water bath and the absorbance was measured by using a UV-Vis spectrophotometer to evaluate the cumulative release of BZ and investigate the release mechanism. Results: The coaxial approach resulted in fibers with an average diameter of 1.83 mu m and an average pore size of 16.11 mu m super(2). Furthermore, the release time prolonged for 7 days; the amount of drug released in the first 8 hours was reduced from 65.1% to 11.65% and the encapsulation efficiency increased from 87.5% to 97.1% in contrast to single jet electrospun fibers, following a Fickian diffusion. Conclusions: Core-shell fibers with the antiseptic agent inside the core can be considered as drug delivery carriers for sustained release in wound healing applications in clinical practice.
doi10.5301/ijao.5000347
urlhttp://search.proquest.com/docview/1793288499/
eissn17246040
date2014-01-01