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Left ventricular remodelling changes without concomitant loss of myocardial fat after long-term dietary intervention.

BACKGROUNDAccumulation of myocardial triglycerides (MTG) is associated with impaired left ventricular (LV) remodelling and function in obese and diabetic subjects. The role of MTG accumulation in development of heart failure in this group of patients is unknown. Short-term studies suggest that diets... Full description

Journal Title: International journal of cardiology August 1, 2016, Vol.216, pp.92-96
Main Author: Andersson, Jonas
Other Authors: Mellberg, Caroline , Otten, Julia , Ryberg, Mats , Rinnström, Daniel , Larsson, Christel , Lindahl, Bernt , Hauksson, Jon , Johansson, Bengt , Olsson, Tommy
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1874-1754 ; DOI: 10.1016/j.ijcard.2016.04.050
Link: http://search.proquest.com/docview/1793906071/?pq-origsite=primo
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title: Left ventricular remodelling changes without concomitant loss of myocardial fat after long-term dietary intervention.
format: Article
creator:
  • Andersson, Jonas
  • Mellberg, Caroline
  • Otten, Julia
  • Ryberg, Mats
  • Rinnström, Daniel
  • Larsson, Christel
  • Lindahl, Bernt
  • Hauksson, Jon
  • Johansson, Bengt
  • Olsson, Tommy
subjects:
  • Body Mass Index–Methods
  • Diet, Fat-Restricted–Metabolism
  • Diet, Paleolithic–Blood
  • Female–Metabolism
  • Humans–Drug Effects
  • Magnetic Resonance Imaging, Cine–Drug Effects
  • Myocardium–Drug Effects
  • Postmenopause–Drug Effects
  • Random Allocation–Drug Effects
  • Treatment Outcome–Drug Effects
  • Triglycerides–Drug Effects
  • Ventricular Function, Left–Drug Effects
  • Ventricular Remodeling–Drug Effects
  • Triglycerides
  • Cardiac Magnetic Resonance (Cmr) Imaging
  • Diet
  • Metabolic Heart Disease
  • Obesity
  • Weight Reduction
ispartof: International journal of cardiology, August 1, 2016, Vol.216, pp.92-96
description: BACKGROUNDAccumulation of myocardial triglycerides (MTG) is associated with impaired left ventricular (LV) remodelling and function in obese and diabetic subjects. The role of MTG accumulation in development of heart failure in this group of patients is unknown. Short-term studies suggest that diets that lead to weight loss could mobilize MTG, with a favourable effect on cardiac remodelling. In a 24-month, randomized, investigator-blinded study, we assessed the effect of two different diets and subsequent weight loss on cardiac function and MTG in postmenopausal women. METHODSSixty-eight healthy postmenopausal women with body mass index [BMI] ≥27kg/m(2) were randomized to an ad libitum Palaeolithic diet (PD) or a Nordic Nutrition Recommendation (NNR) diet for 24months. Morphology, cardiac function, and MTG levels were measured using magnetic resonance (MR) scanning, including proton spectroscopy at baseline and 6 and 24months. RESULTSDespite mean weight losses of 4.9 (1.0) kg (NNR) and...
language: eng
source:
identifier: E-ISSN: 1874-1754 ; DOI: 10.1016/j.ijcard.2016.04.050
fulltext: fulltext
issn:
  • 18741754
  • 1874-1754
url: Link


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titleLeft ventricular remodelling changes without concomitant loss of myocardial fat after long-term dietary intervention.
creatorAndersson, Jonas ; Mellberg, Caroline ; Otten, Julia ; Ryberg, Mats ; Rinnström, Daniel ; Larsson, Christel ; Lindahl, Bernt ; Hauksson, Jon ; Johansson, Bengt ; Olsson, Tommy
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ispartofInternational journal of cardiology, August 1, 2016, Vol.216, pp.92-96
identifierE-ISSN: 1874-1754 ; DOI: 10.1016/j.ijcard.2016.04.050
subjectBody Mass Index–Methods ; Diet, Fat-Restricted–Metabolism ; Diet, Paleolithic–Blood ; Female–Metabolism ; Humans–Drug Effects ; Magnetic Resonance Imaging, Cine–Drug Effects ; Myocardium–Drug Effects ; Postmenopause–Drug Effects ; Random Allocation–Drug Effects ; Treatment Outcome–Drug Effects ; Triglycerides–Drug Effects ; Ventricular Function, Left–Drug Effects ; Ventricular Remodeling–Drug Effects ; Triglycerides ; Cardiac Magnetic Resonance (Cmr) Imaging ; Diet ; Metabolic Heart Disease ; Obesity ; Weight Reduction
descriptionBACKGROUNDAccumulation of myocardial triglycerides (MTG) is associated with impaired left ventricular (LV) remodelling and function in obese and diabetic subjects. The role of MTG accumulation in development of heart failure in this group of patients is unknown. Short-term studies suggest that diets that lead to weight loss could mobilize MTG, with a favourable effect on cardiac remodelling. In a 24-month, randomized, investigator-blinded study, we assessed the effect of two different diets and subsequent weight loss on cardiac function and MTG in postmenopausal women. METHODSSixty-eight healthy postmenopausal women with body mass index [BMI] ≥27kg/m(2) were randomized to an ad libitum Palaeolithic diet (PD) or a Nordic Nutrition Recommendation (NNR) diet for 24months. Morphology, cardiac function, and MTG levels were measured using magnetic resonance (MR) scanning, including proton spectroscopy at baseline and 6 and 24months. RESULTSDespite mean weight losses of 4.9 (1.0) kg (NNR) and...
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titleLeft ventricular remodelling changes without concomitant loss of myocardial fat after long-term dietary intervention.
descriptionBACKGROUNDAccumulation of myocardial triglycerides (MTG) is associated with impaired left ventricular (LV) remodelling and function in obese and diabetic subjects. The role of MTG accumulation in development of heart failure in this group of patients is unknown. Short-term studies suggest that diets that lead to weight loss could mobilize MTG, with a favourable effect on cardiac remodelling. In a 24-month, randomized, investigator-blinded study, we assessed the effect of two different diets and subsequent weight loss on cardiac function and MTG in postmenopausal women. METHODSSixty-eight healthy postmenopausal women with body mass index [BMI] ≥27kg/m(2) were randomized to an ad libitum Palaeolithic diet (PD) or a Nordic Nutrition Recommendation (NNR) diet for 24months. Morphology, cardiac function, and MTG levels were measured using magnetic resonance (MR) scanning, including proton spectroscopy at baseline and 6 and 24months. RESULTSDespite mean weight losses of 4.9 (1.0) kg (NNR) and...
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titleLeft ventricular remodelling changes without concomitant loss of myocardial fat after long-term dietary intervention.
authorAndersson, Jonas ; Mellberg, Caroline ; Otten, Julia ; Ryberg, Mats ; Rinnström, Daniel ; Larsson, Christel ; Lindahl, Bernt ; Hauksson, Jon ; Johansson, Bengt ; Olsson, Tommy
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abstractBACKGROUNDAccumulation of myocardial triglycerides (MTG) is associated with impaired left ventricular (LV) remodelling and function in obese and diabetic subjects. The role of MTG accumulation in development of heart failure in this group of patients is unknown. Short-term studies suggest that diets that lead to weight loss could mobilize MTG, with a favourable effect on cardiac remodelling. In a 24-month, randomized, investigator-blinded study, we assessed the effect of two different diets and subsequent weight loss on cardiac function and MTG in postmenopausal women. METHODSSixty-eight healthy postmenopausal women with body mass index [BMI] ≥27kg/m(2) were randomized to an ad libitum Palaeolithic diet (PD) or a Nordic Nutrition Recommendation (NNR) diet for 24months. Morphology, cardiac function, and MTG levels were measured using magnetic resonance (MR) scanning, including proton spectroscopy at baseline and 6 and 24months. RESULTSDespite mean weight losses of 4.9 (1.0) kg (NNR) and...
doi10.1016/j.ijcard.2016.04.050
urlhttp://search.proquest.com/docview/1793906071/
issn01675273
date2016-08-01