schliessen

Filtern

 

Bibliotheken

SMART: Statistical Metabolomics Analysis-An R Tool.

Metabolomics data provide unprecedented opportunities to decipher metabolic mechanisms by analyzing hundreds to thousands of metabolites. Data quality concerns and complex batch effects in metabolomics must be appropriately addressed through statistical analysis. This study developed an integrated a... Full description

Journal Title: Analytical chemistry June 21, 2016, Vol.88(12), pp.6334-6341
Main Author: Liang, Yu-Jen
Other Authors: Lin, Yu-Ting , Chen, Chia-Wei , Lin, Chien-Wei , Chao, Kun-Mao , Pan, Wen-Harn , Yang, Hsin-Chou
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1520-6882 ; DOI: 1520-6882 ; DOI: 10.1021/acs.analchem.6b00603
Link: http://search.proquest.com/docview/1798991922/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1798991922
title: SMART: Statistical Metabolomics Analysis-An R Tool.
format: Article
creator:
  • Liang, Yu-Jen
  • Lin, Yu-Ting
  • Chen, Chia-Wei
  • Lin, Chien-Wei
  • Chao, Kun-Mao
  • Pan, Wen-Harn
  • Yang, Hsin-Chou
subjects:
  • Analysis of Variance–Analysis
  • Gas Chromatography-Mass Spectrometry–Analysis
  • Internet–Antagonists & Inhibitors
  • Metabolomics–Metabolism
  • Neurotensin–Metabolism
  • Peptide Fragments–Metabolism
  • Renin–Metabolism
  • User-Computer Interface–Metabolism
  • Peptide Fragments
  • Neuromedin N
  • Neurotensin
  • Renin
ispartof: Analytical chemistry, June 21, 2016, Vol.88(12), pp.6334-6341
description: Metabolomics data provide unprecedented opportunities to decipher metabolic mechanisms by analyzing hundreds to thousands of metabolites. Data quality concerns and complex batch effects in metabolomics must be appropriately addressed through statistical analysis. This study developed an integrated analysis tool for metabolomics studies to streamline the complete analysis flow from initial data preprocessing to downstream association analysis. We developed Statistical Metabolomics Analysis -- An R Tool (SMART), which can analyze input files with different formats, visually represent various types of data features, implement peak alignment and annotation, conduct quality control for samples and peaks, explore batch effects, and perform association analysis. A pharmacometabolomics study of antihypertensive medication was conducted and data were analyzed using SMART. Neuromedin N was identified as a metabolite significantly associated with angiotensin-converting-enzyme inhibitors in our metabolome-wide association analysis (p = 1.56 x 10 super( -4) in an analysis of covariance (ANCOVA) with an adjustment for unknown latent groups and p = 1.02 x 10 super( -4) in an ANCOVA with an adjustment for hidden substructures). This endogenous neuropeptide is highly related to neurotensin and neuromedin U, which are involved in blood pressure regulation and smooth muscle contraction. The SMART software, a user guide, and example data can be downloaded from http://www.stat.sinica.edu.tw/hsinchou/metabolomics/SMART.htm.
language: eng
source:
identifier: E-ISSN: 1520-6882 ; DOI: 1520-6882 ; DOI: 10.1021/acs.analchem.6b00603
fulltext: no_fulltext
issn:
  • 15206882
  • 1520-6882
url: Link


@attributes
ID1127212730
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1798991922
sourceidproquest
recordidTN_proquest1798991922
sourcesystemOther
pqid1798991922
display
typearticle
titleSMART: Statistical Metabolomics Analysis-An R Tool.
creatorLiang, Yu-Jen ; Lin, Yu-Ting ; Chen, Chia-Wei ; Lin, Chien-Wei ; Chao, Kun-Mao ; Pan, Wen-Harn ; Yang, Hsin-Chou
contributorLiang, Yu-Jen (correspondence author) ; Liang, Yu-Jen (record owner)
ispartofAnalytical chemistry, June 21, 2016, Vol.88(12), pp.6334-6341
identifier
subjectAnalysis of Variance–Analysis ; Gas Chromatography-Mass Spectrometry–Analysis ; Internet–Antagonists & Inhibitors ; Metabolomics–Metabolism ; Neurotensin–Metabolism ; Peptide Fragments–Metabolism ; Renin–Metabolism ; User-Computer Interface–Metabolism ; Peptide Fragments ; Neuromedin N ; Neurotensin ; Renin
languageeng
source
descriptionMetabolomics data provide unprecedented opportunities to decipher metabolic mechanisms by analyzing hundreds to thousands of metabolites. Data quality concerns and complex batch effects in metabolomics must be appropriately addressed through statistical analysis. This study developed an integrated analysis tool for metabolomics studies to streamline the complete analysis flow from initial data preprocessing to downstream association analysis. We developed Statistical Metabolomics Analysis -- An R Tool (SMART), which can analyze input files with different formats, visually represent various types of data features, implement peak alignment and annotation, conduct quality control for samples and peaks, explore batch effects, and perform association analysis. A pharmacometabolomics study of antihypertensive medication was conducted and data were analyzed using SMART. Neuromedin N was identified as a metabolite significantly associated with angiotensin-converting-enzyme inhibitors in our metabolome-wide association analysis (p = 1.56 x 10 super( -4) in an analysis of covariance (ANCOVA) with an adjustment for unknown latent groups and p = 1.02 x 10 super( -4) in an ANCOVA with an adjustment for hidden substructures). This endogenous neuropeptide is highly related to neurotensin and neuromedin U, which are involved in blood pressure regulation and smooth muscle contraction. The SMART software, a user guide, and example data can be downloaded from http://www.stat.sinica.edu.tw/hsinchou/metabolomics/SMART.htm.
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1798991922/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Liang, Yu-Jen
1Lin, Yu-Ting
2Chen, Chia-Wei
3Lin, Chien-Wei
4Chao, Kun-Mao
5Pan, Wen-Harn
6Yang, Hsin-Chou
titleSMART: Statistical Metabolomics Analysis-An R Tool.
subject
0Analysis of Variance–Analysis
1Gas Chromatography-Mass Spectrometry–Analysis
2Internet–Antagonists & Inhibitors
3Metabolomics–Metabolism
4Neurotensin–Metabolism
5Peptide Fragments–Metabolism
6Renin–Metabolism
7User-Computer Interface–Metabolism
8Peptide Fragments
9Neuromedin N
10Neurotensin
11Renin
general
0English
11520-6882
210.1021/acs.analchem.6b00603
3MEDLINE (ProQuest)
4ProQuest Biological Science Collection
5ProQuest Natural Science Collection
6ProQuest SciTech Collection
7Biological Science Database
8Natural Science Collection
9SciTech Premium Collection
10Health Research Premium Collection
11Health Research Premium Collection (Alumni edition)
sourceidproquest
recordidproquest1798991922
issn
015206882
11520-6882
rsrctypearticle
creationdate2016
addtitleAnalytical chemistry
searchscope
01007527
11007944
210000004
310000038
410000050
510000120
610000159
710000238
810000253
910000260
1010000270
1110000271
1210000302
13proquest
scope
01007527
11007944
210000004
310000038
410000050
510000120
610000159
710000238
810000253
910000260
1010000270
1110000271
1210000302
13proquest
lsr43
01007527false
11007944false
210000004false
310000038false
410000050false
510000120false
610000159false
710000238false
810000253false
910000260false
1010000270false
1110000271false
1210000302false
contributorLiang, Yu-Jen
startdate20160621
enddate20160621
citationpf 6334 pt 6341 vol 88 issue 12
lsr30VSR-Enriched:[issn, description, pqid]
sort
titleSMART: Statistical Metabolomics Analysis-An R Tool.
authorLiang, Yu-Jen ; Lin, Yu-Ting ; Chen, Chia-Wei ; Lin, Chien-Wei ; Chao, Kun-Mao ; Pan, Wen-Harn ; Yang, Hsin-Chou
creationdate20160621
lso0120160621
facets
frbrgroupid5517740938204554814
frbrtype5
newrecords20181218
languageeng
creationdate2016
topic
0Analysis of Variance–Analysis
1Gas Chromatography-Mass Spectrometry–Analysis
2Internet–Antagonists & Inhibitors
3Metabolomics–Metabolism
4Neurotensin–Metabolism
5Peptide Fragments–Metabolism
6Renin–Metabolism
7User-Computer Interface–Metabolism
8Peptide Fragments
9Neuromedin N
10Neurotensin
11Renin
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
prefilterarticles
rsrctypearticles
creatorcontrib
0Liang, Yu-Jen
1Lin, Yu-Ting
2Chen, Chia-Wei
3Lin, Chien-Wei
4Chao, Kun-Mao
5Pan, Wen-Harn
6Yang, Hsin-Chou
jtitleAnalytical chemistry
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
aulast
0Liang
1Lin
2Chen
3Chao
4Pan
5Yang
aufirst
0Yu-Jen
1Yu-Ting
2Chia-Wei
3Chien-Wei
4Kun-Mao
5Wen-Harn
6Hsin-Chou
au
0Liang, Yu-Jen
1Lin, Yu-Ting
2Chen, Chia-Wei
3Lin, Chien-Wei
4Chao, Kun-Mao
5Pan, Wen-Harn
6Yang, Hsin-Chou
addauLiang, Yu-Jen
atitleSMART: Statistical Metabolomics Analysis-An R Tool.
jtitleAnalytical chemistry
risdate20160621
volume88
issue12
spage6334
epage6341
pages6334-6341
eissn1520-6882
formatjournal
genrearticle
ristypeJOUR
doi10.1021/acs.analchem.6b00603
urlhttp://search.proquest.com/docview/1798991922/
issn00032700
date2016-06-21