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Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism

A key sensor of cellular energy status, AMP-activated protein kinase (AMPK), interacts allosterically with AMP to maintain an active state. When active, AMPK triggers a metabolic switch, decreasing the activity of anabolic pathways and enhancing catabolic processes such as lipid oxidation to restore... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America Jun 14, 2016, Vol.113(24), p.E3423
Main Author: Madiraju, Anila
Other Authors: Alves, Tiago , Zhao, Xiaojian , Cline, Gary , Zhang, Dongyan , Bhanot, Sanjay , Samuel, Varman , Kibbey, Richard , Shulman, Gerald
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 00278424 ; E-ISSN: 10916490
Link: http://search.proquest.com/docview/1799224969/?pq-origsite=primo
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title: Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism
format: Article
creator:
  • Madiraju, Anila
  • Alves, Tiago
  • Zhao, Xiaojian
  • Cline, Gary
  • Zhang, Dongyan
  • Bhanot, Sanjay
  • Samuel, Varman
  • Kibbey, Richard
  • Shulman, Gerald
subjects:
  • Enzymes
  • Liver
  • Proteins
  • Lipids
  • Metabolism
  • Phosphorylation
ispartof: Proceedings of the National Academy of Sciences of the United States of America, Jun 14, 2016, Vol.113(24), p.E3423
description: A key sensor of cellular energy status, AMP-activated protein kinase (AMPK), interacts allosterically with AMP to maintain an active state. When active, AMPK triggers a metabolic switch, decreasing the activity of anabolic pathways and enhancing catabolic processes such as lipid oxidation to restore...
language: eng
source:
identifier: ISSN: 00278424 ; E-ISSN: 10916490
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  • 00278424
  • 0027-8424
  • 10916490
  • 1091-6490
url: Link


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titleArgininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism
creatorMadiraju, Anila ; Alves, Tiago ; Zhao, Xiaojian ; Cline, Gary ; Zhang, Dongyan ; Bhanot, Sanjay ; Samuel, Varman ; Kibbey, Richard ; Shulman, Gerald
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subjectEnzymes ; Liver ; Proteins ; Lipids ; Metabolism ; Phosphorylation
descriptionA key sensor of cellular energy status, AMP-activated protein kinase (AMPK), interacts allosterically with AMP to maintain an active state. When active, AMPK triggers a metabolic switch, decreasing the activity of anabolic pathways and enhancing catabolic processes such as lipid oxidation to restore...
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titleArgininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism
authorMadiraju, Anila ; Alves, Tiago ; Zhao, Xiaojian ; Cline, Gary ; Zhang, Dongyan ; Bhanot, Sanjay ; Samuel, Varman ; Kibbey, Richard ; Shulman, Gerald
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abstractA key sensor of cellular energy status, AMP-activated protein kinase (AMPK), interacts allosterically with AMP to maintain an active state. When active, AMPK triggers a metabolic switch, decreasing the activity of anabolic pathways and enhancing catabolic processes such as lipid oxidation to restore...
copWashington
pubNational Academy of Sciences
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doi10.1073/pnas.1606022113
date2016-06-14