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Nucleic-acid recognition interfaces: how the greater ability of RNA duplexes to bend towards the surface influences electrochemical sensor performance

The influence of RNA versusDNA on the performance of electrochemical biosensors where redox-labelled nucleic acid duplexes bend towards the electrode surface has been assessed. Faster electron transfer was observed for duplexes containing RNA, suggesting duplexes with RNA are more flexible. These da... Full description

Journal Title: Chemical Communications: Chem Comm November 2015, Vol.51(92), pp.16526-16529
Main Author: Tavallaie, Roya
Other Authors: Darwish, Nadim , Brynn Hibbert, D , Justin Gooding, J
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c5cc05450h
Link: http://search.proquest.com/docview/1800465767/?pq-origsite=primo
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recordid: proquest1800465767
title: Nucleic-acid recognition interfaces: how the greater ability of RNA duplexes to bend towards the surface influences electrochemical sensor performance
format: Article
creator:
  • Tavallaie, Roya
  • Darwish, Nadim
  • Brynn Hibbert, D
  • Justin Gooding, J
subjects:
  • Biosensors
  • Sensors
  • Ribonucleic Acids
  • Recognition
  • Electrodes
  • Electron Transfer
  • Bend Tests
  • Nucleic Acids
  • Miscellaneous Sciences (So)
  • Chemical and Electrochemical Properties (MD)
  • Chemical and Electrochemical Properties (Ep)
  • Chemical and Electrochemical Properties (Ed)
  • Chemical and Electrochemical Properties (EC)
ispartof: Chemical Communications: Chem Comm, November 2015, Vol.51(92), pp.16526-16529
description: The influence of RNA versusDNA on the performance of electrochemical biosensors where redox-labelled nucleic acid duplexes bend towards the electrode surface has been assessed. Faster electron transfer was observed for duplexes containing RNA, suggesting duplexes with RNA are more flexible. These data are of particular importance for microRNA biosensors.
language: eng
source:
identifier: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c5cc05450h
fulltext: fulltext
issn:
  • 13597345
  • 1359-7345
  • 1364548X
  • 1364-548X
url: Link


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descriptionThe influence of RNA versusDNA on the performance of electrochemical biosensors where redox-labelled nucleic acid duplexes bend towards the electrode surface has been assessed. Faster electron transfer was observed for duplexes containing RNA, suggesting duplexes with RNA are more flexible. These data are of particular importance for microRNA biosensors.
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abstractThe influence of RNA versusDNA on the performance of electrochemical biosensors where redox-labelled nucleic acid duplexes bend towards the electrode surface has been assessed. Faster electron transfer was observed for duplexes containing RNA, suggesting duplexes with RNA are more flexible. These data are of particular importance for microRNA biosensors.
doi10.1039/c5cc05450h
urlhttp://search.proquest.com/docview/1800465767/
date2015-11-01