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Small molecule-mediated duplex formation of nucleic acids with 'incompatible' backbones

Proflavine, a known intercalator of DNA and RNA, promotes duplex formation by nucleic acids with natural and non-natural backbones that otherwise form duplexes with low thermal stability, and even some that show no sign of duplex formation in the absence of proflavine. These findings demonstrate the... Full description

Journal Title: Chemical Communications: Chem Comm April 2016, Vol.52(31), pp.5436-5439
Main Author: Cafferty, Brian
Other Authors: Musetti, Caterina , Kim, Keunsoo , Horowitz, Eric , Krishnamurthy, Ramanarayanan , Hud, Nicholas
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c6cc00779a
Link: http://search.proquest.com/docview/1808107863/?pq-origsite=primo
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recordid: proquest1808107863
title: Small molecule-mediated duplex formation of nucleic acids with 'incompatible' backbones
format: Article
creator:
  • Cafferty, Brian
  • Musetti, Caterina
  • Kim, Keunsoo
  • Horowitz, Eric
  • Krishnamurthy, Ramanarayanan
  • Hud, Nicholas
subjects:
  • Formations
  • Ribonucleic Acids
  • Backbone
  • Deoxyribonucleic Acid
  • Assembly
  • Thermal Stability
  • Intercalation
  • Nucleic Acids
  • Miscellaneous Sciences (So)
  • Chemical and Electrochemical Properties (MD)
  • Chemical and Electrochemical Properties (Ep)
  • Chemical and Electrochemical Properties (Ed)
  • Chemical and Electrochemical Properties (EC)
ispartof: Chemical Communications: Chem Comm, April 2016, Vol.52(31), pp.5436-5439
description: Proflavine, a known intercalator of DNA and RNA, promotes duplex formation by nucleic acids with natural and non-natural backbones that otherwise form duplexes with low thermal stability, and even some that show no sign of duplex formation in the absence of proflavine. These findings demonstrate the potential for intercalators to be used as cofactors for the assembly of rationally designed nucleic acid structures, and could provide fundamental insights regarding intercalation of natural nucleic acid duplexes.
language: eng
source:
identifier: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c6cc00779a
fulltext: fulltext
issn:
  • 13597345
  • 1359-7345
  • 1364548X
  • 1364-548X
url: Link


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subjectFormations ; Ribonucleic Acids ; Backbone ; Deoxyribonucleic Acid ; Assembly ; Thermal Stability ; Intercalation ; Nucleic Acids ; Miscellaneous Sciences (So) ; Chemical and Electrochemical Properties (MD) ; Chemical and Electrochemical Properties (Ep) ; Chemical and Electrochemical Properties (Ed) ; Chemical and Electrochemical Properties (EC)
descriptionProflavine, a known intercalator of DNA and RNA, promotes duplex formation by nucleic acids with natural and non-natural backbones that otherwise form duplexes with low thermal stability, and even some that show no sign of duplex formation in the absence of proflavine. These findings demonstrate the potential for intercalators to be used as cofactors for the assembly of rationally designed nucleic acid structures, and could provide fundamental insights regarding intercalation of natural nucleic acid duplexes.
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abstractProflavine, a known intercalator of DNA and RNA, promotes duplex formation by nucleic acids with natural and non-natural backbones that otherwise form duplexes with low thermal stability, and even some that show no sign of duplex formation in the absence of proflavine. These findings demonstrate the potential for intercalators to be used as cofactors for the assembly of rationally designed nucleic acid structures, and could provide fundamental insights regarding intercalation of natural nucleic acid duplexes.
doi10.1039/c6cc00779a
urlhttp://search.proquest.com/docview/1808107863/
date2016-04-01