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Promoter methylation of RNF180 is associated with H.pylori infection and serves as a marker for gastric cancer and atrophic gastritis.

Promoter methylation (PM) of RING-finger protein (RNF) 180 affects gastric cancer (GC) prognosis, but its association with risk of GC or atrophic gastritis (AG) is unclear. We investigated relationships between RNF180 PM and GC or AG, and the effects of Helicobactor pylori (H.pylori) infection on RN... Full description

Journal Title: Oncotarget April 26, 2016, Vol.7(17), pp.24800-24809
Main Author: Han, Fang
Other Authors: Sun, Li-Ping , Liu, Shuang , Xu, Qian , Liang, Qiao-Yi , Zhang, Zhe , Cao, Hai-Chao , Yu, Jun , Fan, Dai-Ming , Nie, Yong-Zhan , Wu, Kai-Chun , Yuan, Yuan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.8523
Link: http://search.proquest.com/docview/1808376052/?pq-origsite=primo
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recordid: proquest1808376052
title: Promoter methylation of RNF180 is associated with H.pylori infection and serves as a marker for gastric cancer and atrophic gastritis.
format: Article
creator:
  • Han, Fang
  • Sun, Li-Ping
  • Liu, Shuang
  • Xu, Qian
  • Liang, Qiao-Yi
  • Zhang, Zhe
  • Cao, Hai-Chao
  • Yu, Jun
  • Fan, Dai-Ming
  • Nie, Yong-Zhan
  • Wu, Kai-Chun
  • Yuan, Yuan
subjects:
  • Biomarkers, Tumor–Genetics
  • Cpg Islands–Genetics
  • DNA Methylation–Microbiology
  • Disease Progression–Genetics
  • Female–Genetics
  • Gastritis, Atrophic–Microbiology
  • Helicobacter Infections–Genetics
  • Humans–Genetics
  • Male–Genetics
  • Middle Aged–Genetics
  • Prognosis–Genetics
  • Promoter Regions, Genetic–Genetics
  • Stomach Neoplasms–Genetics
  • Ubiquitin-Protein Ligases–Genetics
  • Biomarkers, Tumor
  • Rnf180 Protein, Human
  • Ubiquitin-Protein Ligases
  • Cpg Islands
  • Atrophic Gastritis
  • Bisulfite Genomic Sequencing
  • Gastric Cancer
  • Methylation
ispartof: Oncotarget, April 26, 2016, Vol.7(17), pp.24800-24809
description: Promoter methylation (PM) of RING-finger protein (RNF) 180 affects gastric cancer (GC) prognosis, but its association with risk of GC or atrophic gastritis (AG) is unclear. We investigated relationships between RNF180 PM and GC or AG, and the effects of Helicobactor pylori (H.pylori) infection on RNF180 PM. This study included 513 subjects (159 with GC, 186 with AG, and 168 healthy controls [CON]) for RNF180 PM analysis, and another 55 GC patients for RNF180 gene expression analysis. Methylation was quantified using average methylation rates (AMR), methylated CpG site counts (MSC) and hypermethylated CpG site counts (HSC). RNF180 promoter AMR and MSC increased with disease severity. Optimal cut-offs were GC + AG: AMR > 0.153, MSC > 4 or HSC > 1; GC: AMR > 0.316, MSC > 15 and HSC > 6. Hypermethylation at 5 CpG sites differed significantly between GC/AG and CON groups, and was more common in GC patients than AG and CON groups for 2 other CpG sites. The expression of RNF180 mRNA levels in...
language: eng
source:
identifier: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.8523
fulltext: fulltext
issn:
  • 19492553
  • 1949-2553
url: Link


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titlePromoter methylation of RNF180 is associated with H.pylori infection and serves as a marker for gastric cancer and atrophic gastritis.
creatorHan, Fang ; Sun, Li-Ping ; Liu, Shuang ; Xu, Qian ; Liang, Qiao-Yi ; Zhang, Zhe ; Cao, Hai-Chao ; Yu, Jun ; Fan, Dai-Ming ; Nie, Yong-Zhan ; Wu, Kai-Chun ; Yuan, Yuan
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ispartofOncotarget, April 26, 2016, Vol.7(17), pp.24800-24809
identifierE-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.8523
subjectBiomarkers, Tumor–Genetics ; Cpg Islands–Genetics ; DNA Methylation–Microbiology ; Disease Progression–Genetics ; Female–Genetics ; Gastritis, Atrophic–Microbiology ; Helicobacter Infections–Genetics ; Humans–Genetics ; Male–Genetics ; Middle Aged–Genetics ; Prognosis–Genetics ; Promoter Regions, Genetic–Genetics ; Stomach Neoplasms–Genetics ; Ubiquitin-Protein Ligases–Genetics ; Biomarkers, Tumor ; Rnf180 Protein, Human ; Ubiquitin-Protein Ligases ; Cpg Islands ; Atrophic Gastritis ; Bisulfite Genomic Sequencing ; Gastric Cancer ; Methylation
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descriptionPromoter methylation (PM) of RING-finger protein (RNF) 180 affects gastric cancer (GC) prognosis, but its association with risk of GC or atrophic gastritis (AG) is unclear. We investigated relationships between RNF180 PM and GC or AG, and the effects of Helicobactor pylori (H.pylori) infection on RNF180 PM. This study included 513 subjects (159 with GC, 186 with AG, and 168 healthy controls [CON]) for RNF180 PM analysis, and another 55 GC patients for RNF180 gene expression analysis. Methylation was quantified using average methylation rates (AMR), methylated CpG site counts (MSC) and hypermethylated CpG site counts (HSC). RNF180 promoter AMR and MSC increased with disease severity. Optimal cut-offs were GC + AG: AMR > 0.153, MSC > 4 or HSC > 1; GC: AMR > 0.316, MSC > 15 and HSC > 6. Hypermethylation at 5 CpG sites differed significantly between GC/AG and CON groups, and was more common in GC patients than AG and CON groups for 2 other CpG sites. The expression of RNF180 mRNA levels in...
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titlePromoter methylation of RNF180 is associated with H.pylori infection and serves as a marker for gastric cancer and atrophic gastritis.
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titlePromoter methylation of RNF180 is associated with H.pylori infection and serves as a marker for gastric cancer and atrophic gastritis.
authorHan, Fang ; Sun, Li-Ping ; Liu, Shuang ; Xu, Qian ; Liang, Qiao-Yi ; Zhang, Zhe ; Cao, Hai-Chao ; Yu, Jun ; Fan, Dai-Ming ; Nie, Yong-Zhan ; Wu, Kai-Chun ; Yuan, Yuan
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