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Exogenous Hormone Use: Oral Contraceptives, Postmenopausal Hormone Therapy, and Health Outcomes in the Nurses' Health Study.

OBJECTIVESTo review the contribution of the Nurses' Health Study (NHS) to our understanding of the complex relationship between exogenous hormones and health outcomes in women. METHODSWe performed a narrative review of the publications of the NHS and NHS II from 1976 to 2016. RESULTSOral contracepti... Full description

Journal Title: American journal of public health September 2016, Vol.106(9), pp.1631-1637
Main Author: Bhupathiraju, Shilpa N
Other Authors: Grodstein, Francine , Stampfer, Meir J , Willett, Walter C , Hu, Frank B , Manson, Joann E
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1541-0048 ; DOI: 10.2105/AJPH.2016.303349
Link: http://search.proquest.com/docview/1811292918/?pq-origsite=primo
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title: Exogenous Hormone Use: Oral Contraceptives, Postmenopausal Hormone Therapy, and Health Outcomes in the Nurses' Health Study.
format: Article
creator:
  • Bhupathiraju, Shilpa N
  • Grodstein, Francine
  • Stampfer, Meir J
  • Willett, Walter C
  • Hu, Frank B
  • Manson, Joann E
subjects:
  • Adult–Administration & Dosage
  • Contraceptives, Oral–Administration & Dosage
  • Epidemiologic Studies–Administration & Dosage
  • Female–Administration & Dosage
  • Hormone Replacement Therapy–Administration & Dosage
  • Humans–Administration & Dosage
  • Longitudinal Studies–Administration & Dosage
  • Middle Aged–Administration & Dosage
  • Nurses–Administration & Dosage
  • Outcome Assessment (Health Care)–Administration & Dosage
ispartof: American journal of public health, September 2016, Vol.106(9), pp.1631-1637
description: OBJECTIVESTo review the contribution of the Nurses' Health Study (NHS) to our understanding of the complex relationship between exogenous hormones and health outcomes in women. METHODSWe performed a narrative review of the publications of the NHS and NHS II from 1976 to 2016. RESULTSOral contraceptive and postmenopausal hormone use were studied in relation to major health outcomes, including cardiovascular disease and cancer. Current or recent oral contraceptive use is associated with a higher risk of cardiovascular disease (mainly among smokers), melanoma, and breast cancer, and a lower risk of colorectal and ovarian cancer. Although hormone therapy is not indicated primarily for chronic disease prevention, findings from the NHS and a recent analysis of the Women's Health Initiative indicate that younger women who are closer to menopause onset have a more favorable risk-benefit profile than do older women from use of hormone therapy for relief of vasomotor symptoms. CONCLUSIONSWith updated...
language: eng
source:
identifier: E-ISSN: 1541-0048 ; DOI: 10.2105/AJPH.2016.303349
fulltext: fulltext
issn:
  • 15410048
  • 1541-0048
url: Link


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titleExogenous Hormone Use: Oral Contraceptives, Postmenopausal Hormone Therapy, and Health Outcomes in the Nurses' Health Study.
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descriptionOBJECTIVESTo review the contribution of the Nurses' Health Study (NHS) to our understanding of the complex relationship between exogenous hormones and health outcomes in women. METHODSWe performed a narrative review of the publications of the NHS and NHS II from 1976 to 2016. RESULTSOral contraceptive and postmenopausal hormone use were studied in relation to major health outcomes, including cardiovascular disease and cancer. Current or recent oral contraceptive use is associated with a higher risk of cardiovascular disease (mainly among smokers), melanoma, and breast cancer, and a lower risk of colorectal and ovarian cancer. Although hormone therapy is not indicated primarily for chronic disease prevention, findings from the NHS and a recent analysis of the Women's Health Initiative indicate that younger women who are closer to menopause onset have a more favorable risk-benefit profile than do older women from use of hormone therapy for relief of vasomotor symptoms. CONCLUSIONSWith updated...
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descriptionOBJECTIVESTo review the contribution of the Nurses' Health Study (NHS) to our understanding of the complex relationship between exogenous hormones and health outcomes in women. METHODSWe performed a narrative review of the publications of the NHS and NHS II from 1976 to 2016. RESULTSOral contraceptive and postmenopausal hormone use were studied in relation to major health outcomes, including cardiovascular disease and cancer. Current or recent oral contraceptive use is associated with a higher risk of cardiovascular disease (mainly among smokers), melanoma, and breast cancer, and a lower risk of colorectal and ovarian cancer. Although hormone therapy is not indicated primarily for chronic disease prevention, findings from the NHS and a recent analysis of the Women's Health Initiative indicate that younger women who are closer to menopause onset have a more favorable risk-benefit profile than do older women from use of hormone therapy for relief of vasomotor symptoms. CONCLUSIONSWith updated...
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abstractOBJECTIVESTo review the contribution of the Nurses' Health Study (NHS) to our understanding of the complex relationship between exogenous hormones and health outcomes in women. METHODSWe performed a narrative review of the publications of the NHS and NHS II from 1976 to 2016. RESULTSOral contraceptive and postmenopausal hormone use were studied in relation to major health outcomes, including cardiovascular disease and cancer. Current or recent oral contraceptive use is associated with a higher risk of cardiovascular disease (mainly among smokers), melanoma, and breast cancer, and a lower risk of colorectal and ovarian cancer. Although hormone therapy is not indicated primarily for chronic disease prevention, findings from the NHS and a recent analysis of the Women's Health Initiative indicate that younger women who are closer to menopause onset have a more favorable risk-benefit profile than do older women from use of hormone therapy for relief of vasomotor symptoms. CONCLUSIONSWith updated...
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date2016-09-01