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Antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit.

The objective of present study was to evaluate the antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit. The parent extract was ethanolic extract while its sub fractions were prepared in n-hexane, chloroform and n-butanol. The method based on scavenging activity and reduction capabili... Full description

Journal Title: Pakistan journal of pharmaceutical sciences July 2016, Vol.29(4 Suppl), pp.1383-1385
Main Author: Noreen, Shabana
Other Authors: Shaheen, Ghazala , Akram, Muhammad , Rashid, Abid , Shah, Syed Muhammad Ali
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1011-601X
Link: http://search.proquest.com/docview/1817553980/?pq-origsite=primo
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title: Antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit.
format: Article
creator:
  • Noreen, Shabana
  • Shaheen, Ghazala
  • Akram, Muhammad
  • Rashid, Abid
  • Shah, Syed Muhammad Ali
subjects:
  • Antioxidants–Pharmacology
  • Biphenyl Compounds–Chemistry
  • Enzyme Inhibitors–Pharmacology
  • Free Radical Scavengers–Pharmacology
  • Fruit–Chemistry
  • Humans–Chemistry
  • Picrates–Pharmacology
  • Plant Extracts–Antagonists & Inhibitors
  • Urease–Chemistry
  • Vaccinium Macrocarpon–Chemistry
  • Antioxidants
  • Biphenyl Compounds
  • Enzyme Inhibitors
  • Free Radical Scavengers
  • Picrates
  • Plant Extracts
  • 1,1-Diphenyl-2-Picrylhydrazyl
  • Urease
ispartof: Pakistan journal of pharmaceutical sciences, July 2016, Vol.29(4 Suppl), pp.1383-1385
description: The objective of present study was to evaluate the antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit. The parent extract was ethanolic extract while its sub fractions were prepared in n-hexane, chloroform and n-butanol. The method based on scavenging activity and reduction capability of 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH). N-butanol fraction was the most effective antioxidant with 87.0±1.15 activity but the activity was less than ascorbic acid i.e. 93.74±0.12. Highly significant urease inhibition was shown by crude ethanolic extract (71.00±0.2a) with IC50 (392.66±2.1) followed by aqueous fraction (68.00±0.5e) with IC50 (159.83±2.8). The results of crude ethanolic extract and aqueous extracts were highly significant (p
language: eng
source:
identifier: ISSN: 1011-601X
fulltext: fulltext
issn:
  • 1011601X
  • 1011-601X
url: Link


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titleAntiurease and anti-oxidant activity of Vaccinium macrocarpon fruit.
creatorNoreen, Shabana ; Shaheen, Ghazala ; Akram, Muhammad ; Rashid, Abid ; Shah, Syed Muhammad Ali
contributorNoreen, Shabana (correspondence author) ; Noreen, Shabana (record owner)
ispartofPakistan journal of pharmaceutical sciences, July 2016, Vol.29(4 Suppl), pp.1383-1385
identifierISSN: 1011-601X
subjectAntioxidants–Pharmacology ; Biphenyl Compounds–Chemistry ; Enzyme Inhibitors–Pharmacology ; Free Radical Scavengers–Pharmacology ; Fruit–Chemistry ; Humans–Chemistry ; Picrates–Pharmacology ; Plant Extracts–Antagonists & Inhibitors ; Urease–Chemistry ; Vaccinium Macrocarpon–Chemistry ; Antioxidants ; Biphenyl Compounds ; Enzyme Inhibitors ; Free Radical Scavengers ; Picrates ; Plant Extracts ; 1,1-Diphenyl-2-Picrylhydrazyl ; Urease
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descriptionThe objective of present study was to evaluate the antiurease and anti-oxidant activity of Vaccinium macrocarpon fruit. The parent extract was ethanolic extract while its sub fractions were prepared in n-hexane, chloroform and n-butanol. The method based on scavenging activity and reduction capability of 1, 1-diphenyl-2-picrylhydrazyl radical (DPPH). N-butanol fraction was the most effective antioxidant with 87.0±1.15 activity but the activity was less than ascorbic acid i.e. 93.74±0.12. Highly significant urease inhibition was shown by crude ethanolic extract (71.00±0.2a) with IC50 (392.66±2.1) followed by aqueous fraction (68.00±0.5e) with IC50 (159.83±2.8). The results of crude ethanolic extract and aqueous extracts were highly significant (p<0.05) than standard Thiourea. Present study showed that Vaccinium macrocarpon exhibits potent antiurease and antioxidant activities.
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