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Associations between nut consumption and inflammatory biomarkers

Increased nut consumption has been associated with reduced risk of cardiovascular disease and type 2 diabetes, as well as a healthy lipid profile. However, the associations between nut consumption and inflammatory biomarkers are unclear. We investigated habitual nut consumption in relation to inflam... Full description

Journal Title: The American Journal of Clinical Nutrition Sep 1, 2016, Vol.104(3), p.722
Main Author: Yu, Zhi
Other Authors: Malik, Vasanti , Keum, Nana , Hu, Frank , Giovannucci, Edward , Stampfer, Meir , Willett, Walter , Fuchs, Charles , Bao, Ying
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 00029165 ; E-ISSN: 19383207
Link: http://search.proquest.com/docview/1817564239/?pq-origsite=primo
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title: Associations between nut consumption and inflammatory biomarkers
format: Article
creator:
  • Yu, Zhi
  • Malik, Vasanti
  • Keum, Nana
  • Hu, Frank
  • Giovannucci, Edward
  • Stampfer, Meir
  • Willett, Walter
  • Fuchs, Charles
  • Bao, Ying
subjects:
  • Nuts
  • Diet
  • Inflammation
  • Biomarkers
ispartof: The American Journal of Clinical Nutrition, Sep 1, 2016, Vol.104(3), p.722
description: Increased nut consumption has been associated with reduced risk of cardiovascular disease and type 2 diabetes, as well as a healthy lipid profile. However, the associations between nut consumption and inflammatory biomarkers are unclear. We investigated habitual nut consumption in relation to inflammatory biomarkers in 2 large cohorts of US men and women. We analyzed cross-sectional data from 5013 participants in the Nurses' Health Study (NHS) and Health Professionals Follow-Up Study (HPFS) who were free of diabetes. Nut intake, defined as intake of peanuts and other nuts, was estimated from food-frequency questionnaires, and cumulative averages from 1986 and 1990 in the NHS and from 1990 and 1994 in the HPFS were used. Plasma biomarkers were collected in 1989-1990 in the NHS and 1993-1995 in the HPFS. Multivariate linear regression was used to assess the associations of nut consumption with fasting plasma C-reactive protein (CRP, n = 4941), interleukin 6 (IL-6, n = 2859), and tumor necrosis factor receptor 2 (TNFR2, n = 2905). A greater intake of nuts was associated with lower amounts of a subset of inflammatory biomarkers, after adjusting for demographic, medical, dietary, and lifestyle variables. The relative concentrations (ratios) and 95% CIs comparing subjects with nut intake of ≥5 times/wk and those in the categories of never or almost never were as follows: CRP: 0.80 (0.69, 0.90), P-trend = 0.0003; and IL-6: 0.86 (0.77, 0.97), P-trend = 0.006. These associations remained significant after further adjustment for body mass index. No significant association was observed with TNFR2. Substituting 3 servings of nuts/wk for 3 servings of red meat, processed meat, eggs, or refined grains/wk was associated with significantly lower CRP (all P < 0.0001) and IL-6 (P ranges from 0.001 to 0.017). Frequent nut consumption was associated with a healthy profile of inflammatory biomarkers.
language: eng
source:
identifier: ISSN: 00029165 ; E-ISSN: 19383207
fulltext: fulltext
issn:
  • 00029165
  • 0002-9165
  • 19383207
  • 1938-3207
url: Link


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subjectNuts ; Diet ; Inflammation ; Biomarkers
descriptionIncreased nut consumption has been associated with reduced risk of cardiovascular disease and type 2 diabetes, as well as a healthy lipid profile. However, the associations between nut consumption and inflammatory biomarkers are unclear. We investigated habitual nut consumption in relation to inflammatory biomarkers in 2 large cohorts of US men and women. We analyzed cross-sectional data from 5013 participants in the Nurses' Health Study (NHS) and Health Professionals Follow-Up Study (HPFS) who were free of diabetes. Nut intake, defined as intake of peanuts and other nuts, was estimated from food-frequency questionnaires, and cumulative averages from 1986 and 1990 in the NHS and from 1990 and 1994 in the HPFS were used. Plasma biomarkers were collected in 1989-1990 in the NHS and 1993-1995 in the HPFS. Multivariate linear regression was used to assess the associations of nut consumption with fasting plasma C-reactive protein (CRP, n = 4941), interleukin 6 (IL-6, n = 2859), and tumor necrosis factor receptor 2 (TNFR2, n = 2905). A greater intake of nuts was associated with lower amounts of a subset of inflammatory biomarkers, after adjusting for demographic, medical, dietary, and lifestyle variables. The relative concentrations (ratios) and 95% CIs comparing subjects with nut intake of ≥5 times/wk and those in the categories of never or almost never were as follows: CRP: 0.80 (0.69, 0.90), P-trend = 0.0003; and IL-6: 0.86 (0.77, 0.97), P-trend = 0.006. These associations remained significant after further adjustment for body mass index. No significant association was observed with TNFR2. Substituting 3 servings of nuts/wk for 3 servings of red meat, processed meat, eggs, or refined grains/wk was associated with significantly lower CRP (all P < 0.0001) and IL-6 (P ranges from 0.001 to 0.017). Frequent nut consumption was associated with a healthy profile of inflammatory biomarkers.
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abstractIncreased nut consumption has been associated with reduced risk of cardiovascular disease and type 2 diabetes, as well as a healthy lipid profile. However, the associations between nut consumption and inflammatory biomarkers are unclear. We investigated habitual nut consumption in relation to inflammatory biomarkers in 2 large cohorts of US men and women. We analyzed cross-sectional data from 5013 participants in the Nurses' Health Study (NHS) and Health Professionals Follow-Up Study (HPFS) who were free of diabetes. Nut intake, defined as intake of peanuts and other nuts, was estimated from food-frequency questionnaires, and cumulative averages from 1986 and 1990 in the NHS and from 1990 and 1994 in the HPFS were used. Plasma biomarkers were collected in 1989-1990 in the NHS and 1993-1995 in the HPFS. Multivariate linear regression was used to assess the associations of nut consumption with fasting plasma C-reactive protein (CRP, n = 4941), interleukin 6 (IL-6, n = 2859), and tumor necrosis factor receptor 2 (TNFR2, n = 2905). A greater intake of nuts was associated with lower amounts of a subset of inflammatory biomarkers, after adjusting for demographic, medical, dietary, and lifestyle variables. The relative concentrations (ratios) and 95% CIs comparing subjects with nut intake of ≥5 times/wk and those in the categories of never or almost never were as follows: CRP: 0.80 (0.69, 0.90), P-trend = 0.0003; and IL-6: 0.86 (0.77, 0.97), P-trend = 0.006. These associations remained significant after further adjustment for body mass index. No significant association was observed with TNFR2. Substituting 3 servings of nuts/wk for 3 servings of red meat, processed meat, eggs, or refined grains/wk was associated with significantly lower CRP (all P < 0.0001) and IL-6 (P ranges from 0.001 to 0.017). Frequent nut consumption was associated with a healthy profile of inflammatory biomarkers.
copBethesda
pubAmerican Society for Clinical Nutrition, Inc.
urlhttp://search.proquest.com/docview/1817564239/
pages722-728
doi10.3945/ajcn.116.134205
date2016-09-01