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Tuning Ciprofloxacin Release Profiles from Liposomally Encapsulated Nanocrystalline Drug.

PURPOSEIn order to attenuate the drug release rate, a single freeze-thaw step was previously shown to convert encapsulated drug into a single nanocrystal within each liposome vesicle. The goal of this study was to alter the nanocrystalline character, and thus the drug encapsulation state and release... Full description

Journal Title: Pharmaceutical research November 2016, Vol.33(11), pp.2748-2762
Main Author: Cipolla, David
Other Authors: Wu, Huiying , Eastman, Simon , Redelmeier, Tom , Gonda, Igor , Chan, Hak-Kim
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1573-904X ; DOI: 1573-904X ; DOI: 10.1007/s11095-016-2002-5
Link: http://search.proquest.com/docview/1825215900/?pq-origsite=primo
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recordid: proquest1825215900
title: Tuning Ciprofloxacin Release Profiles from Liposomally Encapsulated Nanocrystalline Drug.
format: Article
creator:
  • Cipolla, David
  • Wu, Huiying
  • Eastman, Simon
  • Redelmeier, Tom
  • Gonda, Igor
  • Chan, Hak-Kim
subjects:
  • Anti-Bacterial Agents–Chemistry
  • Chemistry, Pharmaceutical–Chemistry
  • Ciprofloxacin–Chemistry
  • Drug Liberation–Chemistry
  • Freezing–Chemistry
  • Humans–Chemistry
  • Liposomes–Chemistry
  • Nanoparticles–Chemistry
  • Particle Size–Chemistry
  • Polysorbates–Chemistry
  • Solubility–Chemistry
  • Surface Properties–Chemistry
  • Surface-Active Agents–Chemistry
  • Anti-Bacterial Agents
  • Liposomes
  • Polysorbates
  • Surface-Active Agents
  • Ciprofloxacin
  • in Vitro Release
  • Liposome
  • Nanocrystal
  • Personalized Medicine
  • Surfactant
ispartof: Pharmaceutical research, November 2016, Vol.33(11), pp.2748-2762
description: PURPOSEIn order to attenuate the drug release rate, a single freeze-thaw step was previously shown to convert encapsulated drug into a single nanocrystal within each liposome vesicle. The goal of this study was to alter the nanocrystalline character, and thus the drug encapsulation state and release profile, by addition of surfactant prior to freeze-thaw. METHODSA liposomal ciprofloxacin (CFI) formulation was modified by the addition of surfactant and frozen. After thawing, these formulations were characterized in terms of drug encapsulation by centrifugation-filtration, liposome structure by cryo-TEM imaging, vesicle size by dynamic light scattering, and in vitro release (IVR) performance. RESULTSThe addition of increasing levels of polysorbate 20 (0.05 to 0.4%) or Brij 30 (0.05 to 0.3%) to the CFI preparations followed by subsequent freeze-thaw, resulted in a greater proportion of vesicles without drug nanocrystals and reduced the extent of growth of the nanocrystals thus leading to modified release rates including an increase in the ratio of non-encapsulated to sustained release of drug. CONCLUSIONSThis study provides another lever to achieve the desired release rate profile from a liposomal formulation by addition of surfactant and subsequent freeze-thaw, and thus may provide a personalized approach to treating patients.
language: eng
source:
identifier: E-ISSN: 1573-904X ; DOI: 1573-904X ; DOI: 10.1007/s11095-016-2002-5
fulltext: fulltext
issn:
  • 1573904X
  • 1573-904X
url: Link


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titleTuning Ciprofloxacin Release Profiles from Liposomally Encapsulated Nanocrystalline Drug.
creatorCipolla, David ; Wu, Huiying ; Eastman, Simon ; Redelmeier, Tom ; Gonda, Igor ; Chan, Hak-Kim
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ispartofPharmaceutical research, November 2016, Vol.33(11), pp.2748-2762
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subjectAnti-Bacterial Agents–Chemistry ; Chemistry, Pharmaceutical–Chemistry ; Ciprofloxacin–Chemistry ; Drug Liberation–Chemistry ; Freezing–Chemistry ; Humans–Chemistry ; Liposomes–Chemistry ; Nanoparticles–Chemistry ; Particle Size–Chemistry ; Polysorbates–Chemistry ; Solubility–Chemistry ; Surface Properties–Chemistry ; Surface-Active Agents–Chemistry ; Anti-Bacterial Agents ; Liposomes ; Polysorbates ; Surface-Active Agents ; Ciprofloxacin ; in Vitro Release ; Liposome ; Nanocrystal ; Personalized Medicine ; Surfactant
descriptionPURPOSEIn order to attenuate the drug release rate, a single freeze-thaw step was previously shown to convert encapsulated drug into a single nanocrystal within each liposome vesicle. The goal of this study was to alter the nanocrystalline character, and thus the drug encapsulation state and release profile, by addition of surfactant prior to freeze-thaw. METHODSA liposomal ciprofloxacin (CFI) formulation was modified by the addition of surfactant and frozen. After thawing, these formulations were characterized in terms of drug encapsulation by centrifugation-filtration, liposome structure by cryo-TEM imaging, vesicle size by dynamic light scattering, and in vitro release (IVR) performance. RESULTSThe addition of increasing levels of polysorbate 20 (0.05 to 0.4%) or Brij 30 (0.05 to 0.3%) to the CFI preparations followed by subsequent freeze-thaw, resulted in a greater proportion of vesicles without drug nanocrystals and reduced the extent of growth of the nanocrystals thus leading to modified release rates including an increase in the ratio of non-encapsulated to sustained release of drug. CONCLUSIONSThis study provides another lever to achieve the desired release rate profile from a liposomal formulation by addition of surfactant and subsequent freeze-thaw, and thus may provide a personalized approach to treating patients.
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titleTuning Ciprofloxacin Release Profiles from Liposomally Encapsulated Nanocrystalline Drug.
descriptionPURPOSEIn order to attenuate the drug release rate, a single freeze-thaw step was previously shown to convert encapsulated drug into a single nanocrystal within each liposome vesicle. The goal of this study was to alter the nanocrystalline character, and thus the drug encapsulation state and release profile, by addition of surfactant prior to freeze-thaw. METHODSA liposomal ciprofloxacin (CFI) formulation was modified by the addition of surfactant and frozen. After thawing, these formulations were characterized in terms of drug encapsulation by centrifugation-filtration, liposome structure by cryo-TEM imaging, vesicle size by dynamic light scattering, and in vitro release (IVR) performance. RESULTSThe addition of increasing levels of polysorbate 20 (0.05 to 0.4%) or Brij 30 (0.05 to 0.3%) to the CFI preparations followed by subsequent freeze-thaw, resulted in a greater proportion of vesicles without drug nanocrystals and reduced the extent of growth of the nanocrystals thus leading to modified release rates including an increase in the ratio of non-encapsulated to sustained release of drug. CONCLUSIONSThis study provides another lever to achieve the desired release rate profile from a liposomal formulation by addition of surfactant and subsequent freeze-thaw, and thus may provide a personalized approach to treating patients.
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titleTuning Ciprofloxacin Release Profiles from Liposomally Encapsulated Nanocrystalline Drug.
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abstractPURPOSEIn order to attenuate the drug release rate, a single freeze-thaw step was previously shown to convert encapsulated drug into a single nanocrystal within each liposome vesicle. The goal of this study was to alter the nanocrystalline character, and thus the drug encapsulation state and release profile, by addition of surfactant prior to freeze-thaw. METHODSA liposomal ciprofloxacin (CFI) formulation was modified by the addition of surfactant and frozen. After thawing, these formulations were characterized in terms of drug encapsulation by centrifugation-filtration, liposome structure by cryo-TEM imaging, vesicle size by dynamic light scattering, and in vitro release (IVR) performance. RESULTSThe addition of increasing levels of polysorbate 20 (0.05 to 0.4%) or Brij 30 (0.05 to 0.3%) to the CFI preparations followed by subsequent freeze-thaw, resulted in a greater proportion of vesicles without drug nanocrystals and reduced the extent of growth of the nanocrystals thus leading to modified release rates including an increase in the ratio of non-encapsulated to sustained release of drug. CONCLUSIONSThis study provides another lever to achieve the desired release rate profile from a liposomal formulation by addition of surfactant and subsequent freeze-thaw, and thus may provide a personalized approach to treating patients.
doi10.1007/s11095-016-2002-5
urlhttp://search.proquest.com/docview/1825215900/
issn07248741
date2016-11-01