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Urine gamma-synuclein as a biomarker for the diagnosis of bladder cancer.

Gamma-synuclein (SNCG) is secreted from tumor cells and elevated in the urine of bladder cancer (BCa) patients, however, the diagnostic and prognostic values of urine SNCG for BCa remain unknown. Here, we used enzyme immunoassay and western blotting to measure urine SNCG levels. Patients with BCa or... Full description

Journal Title: Oncotarget July 12, 2016, Vol.7(28), pp.43432-43441
Main Author: Liu, Caiyun
Other Authors: Shi, Bingbing , Hao, Chonghua , Wang, Qinghai , Lv, Qiang , Xing, Nianzeng , Shou, Jianzhong , Qu, Like , Gao, Yanning , Qin, Chao , Zhao, Jiyu , Shou, Chengchao
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.9468
Link: http://search.proquest.com/docview/1826689298/?pq-origsite=primo
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title: Urine gamma-synuclein as a biomarker for the diagnosis of bladder cancer.
format: Article
creator:
  • Liu, Caiyun
  • Shi, Bingbing
  • Hao, Chonghua
  • Wang, Qinghai
  • Lv, Qiang
  • Xing, Nianzeng
  • Shou, Jianzhong
  • Qu, Like
  • Gao, Yanning
  • Qin, Chao
  • Zhao, Jiyu
  • Shou, Chengchao
subjects:
  • Area Under Curve–Urine
  • Biomarkers, Tumor–Urine
  • Blotting, Western–Urine
  • Cystoscopy–Epidemiology
  • Enzyme-Linked Immunosorbent Assay–Pathology
  • Hematuria–Urine
  • Humans–Urine
  • Neoplasm Grading–Pathology
  • Neoplasm Proteins–Surgery
  • Neoplasm Recurrence, Local–Urine
  • Neoplasm Staging–Urine
  • Nuclear Proteins–Urine
  • Prognosis–Urine
  • Prospective Studies–Urine
  • ROC Curve–Urine
  • Urinary Bladder Neoplasms–Urine
  • Gamma-Synuclein–Urine
  • Biomarkers, Tumor
  • Neoplasm Proteins
  • Nuclear Proteins
  • Sncg Protein, Human
  • Gamma-Synuclein
  • Nuclear Matrix Protein 22
  • Bladder Cancer
  • Diagnosis
  • Gamma-Synuclein
  • Prognosis
  • Urine
ispartof: Oncotarget, July 12, 2016, Vol.7(28), pp.43432-43441
description: Gamma-synuclein (SNCG) is secreted from tumor cells and elevated in the urine of bladder cancer (BCa) patients, however, the diagnostic and prognostic values of urine SNCG for BCa remain unknown. Here, we used enzyme immunoassay and western blotting to measure urine SNCG levels. Patients with BCa or other urological diseases and healthy controls were enrolled at four Chinese hospitals from April 2010 to November 2014. Diagnostic performance was evaluated by analyzing the area under receiver operating characteristic curves (AUROCs). The AUROC was 0.903 ± 0.019 (95% confidence interval [CI], 0.867 - 0.940) for the test and 0.929 ± 0.015 (95% CI, 0.901 - 0.958) for the validation cohort. The optimal cutoff value yielded sensitivities of 68.4%, 62.4% and specificities of 97.4%, 97.8% for the test and validation cohort, respectively. Urine SNCG levels were decreased after tumor resection, but were higher in BCa patients with recurrence than those without (P = 0.001). The urine SNCG levels in...
language: eng
source:
identifier: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.9468
fulltext: fulltext
issn:
  • 19492553
  • 1949-2553
url: Link


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titleUrine gamma-synuclein as a biomarker for the diagnosis of bladder cancer.
creatorLiu, Caiyun ; Shi, Bingbing ; Hao, Chonghua ; Wang, Qinghai ; Lv, Qiang ; Xing, Nianzeng ; Shou, Jianzhong ; Qu, Like ; Gao, Yanning ; Qin, Chao ; Zhao, Jiyu ; Shou, Chengchao
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ispartofOncotarget, July 12, 2016, Vol.7(28), pp.43432-43441
identifierE-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.9468
subjectArea Under Curve–Urine ; Biomarkers, Tumor–Urine ; Blotting, Western–Urine ; Cystoscopy–Epidemiology ; Enzyme-Linked Immunosorbent Assay–Pathology ; Hematuria–Urine ; Humans–Urine ; Neoplasm Grading–Pathology ; Neoplasm Proteins–Surgery ; Neoplasm Recurrence, Local–Urine ; Neoplasm Staging–Urine ; Nuclear Proteins–Urine ; Prognosis–Urine ; Prospective Studies–Urine ; ROC Curve–Urine ; Urinary Bladder Neoplasms–Urine ; Gamma-Synuclein–Urine ; Biomarkers, Tumor ; Neoplasm Proteins ; Nuclear Proteins ; Sncg Protein, Human ; Gamma-Synuclein ; Nuclear Matrix Protein 22 ; Bladder Cancer ; Diagnosis ; Gamma-Synuclein ; Prognosis ; Urine
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descriptionGamma-synuclein (SNCG) is secreted from tumor cells and elevated in the urine of bladder cancer (BCa) patients, however, the diagnostic and prognostic values of urine SNCG for BCa remain unknown. Here, we used enzyme immunoassay and western blotting to measure urine SNCG levels. Patients with BCa or other urological diseases and healthy controls were enrolled at four Chinese hospitals from April 2010 to November 2014. Diagnostic performance was evaluated by analyzing the area under receiver operating characteristic curves (AUROCs). The AUROC was 0.903 ± 0.019 (95% confidence interval [CI], 0.867 - 0.940) for the test and 0.929 ± 0.015 (95% CI, 0.901 - 0.958) for the validation cohort. The optimal cutoff value yielded sensitivities of 68.4%, 62.4% and specificities of 97.4%, 97.8% for the test and validation cohort, respectively. Urine SNCG levels were decreased after tumor resection, but were higher in BCa patients with recurrence than those without (P = 0.001). The urine SNCG levels in...
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authorLiu, Caiyun ; Shi, Bingbing ; Hao, Chonghua ; Wang, Qinghai ; Lv, Qiang ; Xing, Nianzeng ; Shou, Jianzhong ; Qu, Like ; Gao, Yanning ; Qin, Chao ; Zhao, Jiyu ; Shou, Chengchao
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