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Androgen Deprivation Therapy Can Change Proportion of Prostate Cancer Stem Cells

Objective To study the effect of androgen deprivation therapy on prostate cancer stem cells in prostate cancer tissues and to investigate the mechanisms of the formation of androgen independent prostate cancer. Methods Eighteen patients were divided into 2 groups, the ADT (androgen deprivation thera... Full description

Journal Title: Cancer Research on Prevention and Treatment / Zhongliu Fangzhi Yanjiu 0, 2014, Vol.41(2), pp.128-130
Main Author: Chen, Wei
Other Authors: Wang, Guomin
Format: Electronic Article Electronic Article
Language: chi
Subjects:
Quelle: © ProQuest LLC All rights reserved
ID: ISSN: 1000-8578 ; DOI: 10.3971/j.issn.1000-8578.2014.02.008
Link: http://search.proquest.com/docview/1832259534/?pq-origsite=primo
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title: Androgen Deprivation Therapy Can Change Proportion of Prostate Cancer Stem Cells
format: Article
creator:
  • Chen, Wei
  • Wang, Guomin
subjects:
  • Differentiation
  • Stem Cells
  • Prostate Cancer
  • Immunofluorescence
  • Carcinoma
  • Androgens
  • Methods
  • Cancer Stem Cells
  • Androgen Independent Prostate Cancer
  • Androgen Deprivation Therapy
ispartof: Cancer Research on Prevention and Treatment / Zhongliu Fangzhi Yanjiu, 0, 2014, Vol.41(2), pp.128-130
description: Objective To study the effect of androgen deprivation therapy on prostate cancer stem cells in prostate cancer tissues and to investigate the mechanisms of the formation of androgen independent prostate cancer. Methods Eighteen patients were divided into 2 groups, the ADT (androgen deprivation therapy) group and non-ADT group. The proportions of cancer stem cells in preoperative and postoperative prostate cancer tissues were compared with immunofluorescence. Results In the non-ADT group, the differences of cancer stem cell proportion between preoperative and postoperative specimens were not prominent[(3.56 + or -1.33)% vs. (3.78+ or -1.39)% ,n = 9, t =-0.686, P = 0.512]. But in the ADT group, compared with preoperative specimens, the proportion of prostate cancer stem cells was significantly increased after undergoing androgen deprivation therapy for 3 months [(3.44+ or -1.81)% vs. (9.22+ or -1.71)%, n = 9, t = -6.353, P = 0.000]. In the tissue adjacent to carcinoma, stem cell markers were also increased after ADT. Conclusion Androgen probably is involved in the differentiation of prostate stem cells or prostate cancer stem cells. The formation of androgen independent prostate cancer may be related to prostate cancer stem cells.
language: chi
source: © ProQuest LLC All rights reserved
identifier: ISSN: 1000-8578 ; DOI: 10.3971/j.issn.1000-8578.2014.02.008
fulltext: fulltext
issn:
  • 10008578
  • 1000-8578
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titleAndrogen Deprivation Therapy Can Change Proportion of Prostate Cancer Stem Cells
creatorChen, Wei ; Wang, Guomin
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ispartofCancer Research on Prevention and Treatment / Zhongliu Fangzhi Yanjiu, 0, 2014, Vol.41(2), pp.128-130
identifierISSN: 1000-8578 ; DOI: 10.3971/j.issn.1000-8578.2014.02.008
subjectDifferentiation ; Stem Cells ; Prostate Cancer ; Immunofluorescence ; Carcinoma ; Androgens ; Methods ; Cancer Stem Cells ; Androgen Independent Prostate Cancer ; Androgen Deprivation Therapy
descriptionObjective To study the effect of androgen deprivation therapy on prostate cancer stem cells in prostate cancer tissues and to investigate the mechanisms of the formation of androgen independent prostate cancer. Methods Eighteen patients were divided into 2 groups, the ADT (androgen deprivation therapy) group and non-ADT group. The proportions of cancer stem cells in preoperative and postoperative prostate cancer tissues were compared with immunofluorescence. Results In the non-ADT group, the differences of cancer stem cell proportion between preoperative and postoperative specimens were not prominent[(3.56 + or -1.33)% vs. (3.78+ or -1.39)% ,n = 9, t =-0.686, P = 0.512]. But in the ADT group, compared with preoperative specimens, the proportion of prostate cancer stem cells was significantly increased after undergoing androgen deprivation therapy for 3 months [(3.44+ or -1.81)% vs. (9.22+ or -1.71)%, n = 9, t = -6.353, P = 0.000]. In the tissue adjacent to carcinoma, stem cell markers were also increased after ADT. Conclusion Androgen probably is involved in the differentiation of prostate stem cells or prostate cancer stem cells. The formation of androgen independent prostate cancer may be related to prostate cancer stem cells.
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titleAndrogen Deprivation Therapy Can Change Proportion of Prostate Cancer Stem Cells
descriptionObjective To study the effect of androgen deprivation therapy on prostate cancer stem cells in prostate cancer tissues and to investigate the mechanisms of the formation of androgen independent prostate cancer. Methods Eighteen patients were divided into 2 groups, the ADT (androgen deprivation therapy) group and non-ADT group. The proportions of cancer stem cells in preoperative and postoperative prostate cancer tissues were compared with immunofluorescence. Results In the non-ADT group, the differences of cancer stem cell proportion between preoperative and postoperative specimens were not prominent[(3.56 + or -1.33)% vs. (3.78+ or -1.39)% ,n = 9, t =-0.686, P = 0.512]. But in the ADT group, compared with preoperative specimens, the proportion of prostate cancer stem cells was significantly increased after undergoing androgen deprivation therapy for 3 months [(3.44+ or -1.81)% vs. (9.22+ or -1.71)%, n = 9, t = -6.353, P = 0.000]. In the tissue adjacent to carcinoma, stem cell markers were also increased after ADT. Conclusion Androgen probably is involved in the differentiation of prostate stem cells or prostate cancer stem cells. The formation of androgen independent prostate cancer may be related to prostate cancer stem cells.
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abstractObjective To study the effect of androgen deprivation therapy on prostate cancer stem cells in prostate cancer tissues and to investigate the mechanisms of the formation of androgen independent prostate cancer. Methods Eighteen patients were divided into 2 groups, the ADT (androgen deprivation therapy) group and non-ADT group. The proportions of cancer stem cells in preoperative and postoperative prostate cancer tissues were compared with immunofluorescence. Results In the non-ADT group, the differences of cancer stem cell proportion between preoperative and postoperative specimens were not prominent[(3.56 + or -1.33)% vs. (3.78+ or -1.39)% ,n = 9, t =-0.686, P = 0.512]. But in the ADT group, compared with preoperative specimens, the proportion of prostate cancer stem cells was significantly increased after undergoing androgen deprivation therapy for 3 months [(3.44+ or -1.81)% vs. (9.22+ or -1.71)%, n = 9, t = -6.353, P = 0.000]. In the tissue adjacent to carcinoma, stem cell markers were also increased after ADT. Conclusion Androgen probably is involved in the differentiation of prostate stem cells or prostate cancer stem cells. The formation of androgen independent prostate cancer may be related to prostate cancer stem cells.
doi10.3971/j.issn.1000-8578.2014.02.008
urlhttp://search.proquest.com/docview/1832259534/
date2014-01-01