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Genetic Moderation of Intervention Efficacy: Dopaminergic Genes, The Incredible Years, and Externalizing Behavior in Children.

This study investigated whether children scoring higher on a polygenic plasticity index based on five dopaminergic genes (DRD4, DRD2, DAT1, MAOA, and COMT) benefited the most from the Incredible Years (IY) parent program. Data were used from a randomized controlled trial including 341 Dutch families... Full description

Journal Title: Child development May 2017, Vol.88(3), pp.796-811
Main Author: Chhangur, Rabia R
Other Authors: Weeland, Joyce , Overbeek, Geertjan , Matthys, Walter , Orobio de Castro, Bram , van Der Giessen, Danielle , Belsky, Jay
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1467-8624 ; DOI: 10.1111/cdev.12612
Link: http://search.proquest.com/docview/1835362546/?pq-origsite=primo
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title: Genetic Moderation of Intervention Efficacy: Dopaminergic Genes, The Incredible Years, and Externalizing Behavior in Children.
format: Article
creator:
  • Chhangur, Rabia R
  • Weeland, Joyce
  • Overbeek, Geertjan
  • Matthys, Walter
  • Orobio de Castro, Bram
  • van Der Giessen, Danielle
  • Belsky, Jay
subjects:
  • Adult–Physiology
  • Child–Genetics
  • Child Behavior–Methods
  • Child, Preschool–Methods
  • Dopamine–Methods
  • Education, Nonprofessional–Methods
  • Female–Methods
  • Gene-Environment Interaction–Methods
  • Humans–Methods
  • Male–Methods
  • Outcome Assessment (Health Care)–Methods
  • Parenting–Methods
  • Problem Behavior–Methods
  • Dopamine
ispartof: Child development, May 2017, Vol.88(3), pp.796-811
description: This study investigated whether children scoring higher on a polygenic plasticity index based on five dopaminergic genes (DRD4, DRD2, DAT1, MAOA, and COMT) benefited the most from the Incredible Years (IY) parent program. Data were used from a randomized controlled trial including 341 Dutch families with 4- to 8-year-old children (55.7% boys) showing moderate to high levels of problem behavior. IY proved to be most effective in decreasing parent-reported (but not observed) externalizing behavior in boys (but not girls) carrying more rather than fewer dopaminergic plasticity alleles; this Gene × Intervention effect was most pronounced in the case of boys whose parents' manifested the most positive change in parenting in response to the intervention. These results proved robust across a variety of sampling specifications (e.g., intention to treat, ethnicity).
language: eng
source:
identifier: E-ISSN: 1467-8624 ; DOI: 10.1111/cdev.12612
fulltext: fulltext
issn:
  • 14678624
  • 1467-8624
url: Link


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titleGenetic Moderation of Intervention Efficacy: Dopaminergic Genes, The Incredible Years, and Externalizing Behavior in Children.
creatorChhangur, Rabia R ; Weeland, Joyce ; Overbeek, Geertjan ; Matthys, Walter ; Orobio de Castro, Bram ; van Der Giessen, Danielle ; Belsky, Jay
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identifierE-ISSN: 1467-8624 ; DOI: 10.1111/cdev.12612
subjectAdult–Physiology ; Child–Genetics ; Child Behavior–Methods ; Child, Preschool–Methods ; Dopamine–Methods ; Education, Nonprofessional–Methods ; Female–Methods ; Gene-Environment Interaction–Methods ; Humans–Methods ; Male–Methods ; Outcome Assessment (Health Care)–Methods ; Parenting–Methods ; Problem Behavior–Methods ; Dopamine
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descriptionThis study investigated whether children scoring higher on a polygenic plasticity index based on five dopaminergic genes (DRD4, DRD2, DAT1, MAOA, and COMT) benefited the most from the Incredible Years (IY) parent program. Data were used from a randomized controlled trial including 341 Dutch families with 4- to 8-year-old children (55.7% boys) showing moderate to high levels of problem behavior. IY proved to be most effective in decreasing parent-reported (but not observed) externalizing behavior in boys (but not girls) carrying more rather than fewer dopaminergic plasticity alleles; this Gene × Intervention effect was most pronounced in the case of boys whose parents' manifested the most positive change in parenting in response to the intervention. These results proved robust across a variety of sampling specifications (e.g., intention to treat, ethnicity).
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