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Cyr61 participates in the pathogenesis of acute lymphoblastic leukemia by enhancing cellular survival via the AKT/NF-κB signaling pathway.

Cyr61 (CCN1) is the product of a growth factor-inducible immediate early gene and is involved in cell adhesion, survival, proliferation, and differentiation. Cyr61 is overexpressed in human tumors and is involved in the development of tumors. However, the role that Cyr61 plays in acute lymphoblastic... Full description

Journal Title: Scientific reports October 11, 2016, Vol.6, p.34018
Main Author: Zhu, Xianjin
Other Authors: Song, Yanfang , Wu, Conglian , Pan, Chuxi , Lu, Pingxia , Wang, Meihua , Zheng, Peizheng , Huo, Rongfen , Zhang, Chenqing , Li, Wanting , Lin, Yulin , Cao, Yingping , Li, Ningli
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 2045-2322 ; DOI: 10.1038/srep34018
Link: http://search.proquest.com/docview/1835369435/?pq-origsite=primo
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title: Cyr61 participates in the pathogenesis of acute lymphoblastic leukemia by enhancing cellular survival via the AKT/NF-κB signaling pathway.
format: Article
creator:
  • Zhu, Xianjin
  • Song, Yanfang
  • Wu, Conglian
  • Pan, Chuxi
  • Lu, Pingxia
  • Wang, Meihua
  • Zheng, Peizheng
  • Huo, Rongfen
  • Zhang, Chenqing
  • Li, Wanting
  • Lin, Yulin
  • Cao, Yingping
  • Li, Ningli
subjects:
  • Adolescent–Genetics
  • Adult–Genetics
  • Cell Survival–Metabolism
  • Child–Genetics
  • Child, Preschool–Metabolism
  • Cysteine-Rich Protein 61–Genetics
  • Female–Metabolism
  • Humans–Pathology
  • Jurkat Cells–Genetics
  • Male–Metabolism
  • Nf-Kappa B–Genetics
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma–Metabolism
  • Proto-Oncogene Proteins C-Akt–Metabolism
  • Proto-Oncogene Proteins C-Bcl-2–Metabolism
  • Signal Transduction–Metabolism
  • Bcl2 Protein, Human
  • Ccn1 Protein, Human
  • Cysteine-Rich Protein 61
  • Nf-Kappa B
  • Proto-Oncogene Proteins C-Bcl-2
ispartof: Scientific reports, October 11, 2016, Vol.6, p.34018
description: Cyr61 (CCN1) is the product of a growth factor-inducible immediate early gene and is involved in cell adhesion, survival, proliferation, and differentiation. Cyr61 is overexpressed in human tumors and is involved in the development of tumors. However, the role that Cyr61 plays in acute lymphoblastic leukemia (ALL) cells remains undetermined. The aim of this study was to identify the role of Cyr61 in regulating ALL cell survival. Here, we found that the level of Cyr61 was increased in the plasma and bone marrow (BM) from ALL patients compared with samples from normal control patients. Furthermore, we observed that Cyr61 could effectively stimulate Jurkat (T ALL cell lines), Nalm-6 (B ALL cell lines), and primary ALL cell survival. Mechanistically, we showed that Cyr61 stimulated ALL cell survival via the AKT/NF-κB signaling pathways and the consequent up-regulation of Bcl-2. Taken together, our study is the first to reveal that Cyr61 is elevated in ALL and promotes cell survival through the AKT/NF-κB pathway by up-regulating Bcl-2. Our findings suggest that Cyr61 plays an important role in the pathogenesis of ALL.
language: eng
source:
identifier: E-ISSN: 2045-2322 ; DOI: 10.1038/srep34018
fulltext: fulltext
issn:
  • 20452322
  • 2045-2322
url: Link


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titleCyr61 participates in the pathogenesis of acute lymphoblastic leukemia by enhancing cellular survival via the AKT/NF-κB signaling pathway.
creatorZhu, Xianjin ; Song, Yanfang ; Wu, Conglian ; Pan, Chuxi ; Lu, Pingxia ; Wang, Meihua ; Zheng, Peizheng ; Huo, Rongfen ; Zhang, Chenqing ; Li, Wanting ; Lin, Yulin ; Cao, Yingping ; Li, Ningli
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ispartofScientific reports, October 11, 2016, Vol.6, p.34018
identifierE-ISSN: 2045-2322 ; DOI: 10.1038/srep34018
subjectAdolescent–Genetics ; Adult–Genetics ; Cell Survival–Metabolism ; Child–Genetics ; Child, Preschool–Metabolism ; Cysteine-Rich Protein 61–Genetics ; Female–Metabolism ; Humans–Pathology ; Jurkat Cells–Genetics ; Male–Metabolism ; Nf-Kappa B–Genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma–Metabolism ; Proto-Oncogene Proteins C-Akt–Metabolism ; Proto-Oncogene Proteins C-Bcl-2–Metabolism ; Signal Transduction–Metabolism ; Bcl2 Protein, Human ; Ccn1 Protein, Human ; Cysteine-Rich Protein 61 ; Nf-Kappa B ; Proto-Oncogene Proteins C-Bcl-2
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descriptionCyr61 (CCN1) is the product of a growth factor-inducible immediate early gene and is involved in cell adhesion, survival, proliferation, and differentiation. Cyr61 is overexpressed in human tumors and is involved in the development of tumors. However, the role that Cyr61 plays in acute lymphoblastic leukemia (ALL) cells remains undetermined. The aim of this study was to identify the role of Cyr61 in regulating ALL cell survival. Here, we found that the level of Cyr61 was increased in the plasma and bone marrow (BM) from ALL patients compared with samples from normal control patients. Furthermore, we observed that Cyr61 could effectively stimulate Jurkat (T ALL cell lines), Nalm-6 (B ALL cell lines), and primary ALL cell survival. Mechanistically, we showed that Cyr61 stimulated ALL cell survival via the AKT/NF-κB signaling pathways and the consequent up-regulation of Bcl-2. Taken together, our study is the first to reveal that Cyr61 is elevated in ALL and promotes cell survival through the AKT/NF-κB pathway by up-regulating Bcl-2. Our findings suggest that Cyr61 plays an important role in the pathogenesis of ALL.
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titleCyr61 participates in the pathogenesis of acute lymphoblastic leukemia by enhancing cellular survival via the AKT/NF-κB signaling pathway.
authorZhu, Xianjin ; Song, Yanfang ; Wu, Conglian ; Pan, Chuxi ; Lu, Pingxia ; Wang, Meihua ; Zheng, Peizheng ; Huo, Rongfen ; Zhang, Chenqing ; Li, Wanting ; Lin, Yulin ; Cao, Yingping ; Li, Ningli
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