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Antigenotoxic Effect of Piperine in Broiler Chickens Intoxicated with Aflatoxin B1.

Piperine is an abundant amide extracted from black pepper seeds which has been shown to have protective effects against cytotoxic and genotoxic carcinogenesis induced by certain chemical carcinogens and aflatoxin B1 (AFB1) in vitro. The aim of this work was to study, in vivo, the antigenotoxic poten... Full description

Journal Title: Toxins October 31, 2016, Vol.8(11)
Main Author: Da Silva Cardoso, Verônica
Other Authors: Vermelho, Alane Beatriz , Ribeiro de Lima, Cristina Amorim , Mendes de Oliveira, Jéssica , Freire de Lima, Marco Edilson , Pinto Da Silva, Lúcia Helena , Direito, Glória Maria , Miranda Danelli, Maria Das Graças
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 2072-6651 ; DOI: 2072-6651
Link: http://search.proquest.com/docview/1836737088/?pq-origsite=primo
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title: Antigenotoxic Effect of Piperine in Broiler Chickens Intoxicated with Aflatoxin B1.
format: Article
creator:
  • Da Silva Cardoso, Verônica
  • Vermelho, Alane Beatriz
  • Ribeiro de Lima, Cristina Amorim
  • Mendes de Oliveira, Jéssica
  • Freire de Lima, Marco Edilson
  • Pinto Da Silva, Lúcia Helena
  • Direito, Glória Maria
  • Miranda Danelli, Maria Das Graças
subjects:
  • Aflatoxin B1–Toxicity
  • Alkaloids–Pharmacology
  • Animal Feed–Pharmacology
  • Animals–Pharmacology
  • Anticarcinogenic Agents–Toxicity
  • Benzodioxoles–Veterinary
  • Carcinogens–Drug Effects
  • Chickens–Pharmacology
  • Comet Assay–Pharmacology
  • DNA Damage–Drug Effects
  • Diet–Drug Effects
  • Eating–Drug Effects
  • Male–Drug Effects
  • Micronucleus Tests–Drug Effects
  • Piperidines–Drug Effects
  • Polyunsaturated Alkamides–Drug Effects
  • Weight Gain–Drug Effects
  • Alkaloids
  • Anticarcinogenic Agents
  • Benzodioxoles
  • Carcinogens
  • Piperidines
  • Polyunsaturated Alkamides
  • Aflatoxin B1
  • Piperine
  • Aspergillus
  • Aflatoxin B1
  • Broiler Chicken
  • Piperine
ispartof: Toxins, October 31, 2016, Vol.8(11)
description: Piperine is an abundant amide extracted from black pepper seeds which has been shown to have protective effects against cytotoxic and genotoxic carcinogenesis induced by certain chemical carcinogens and aflatoxin B1 (AFB1) in vitro. The aim of this work was to study, in vivo, the antigenotoxic potential of feed-added piperine on broiler chickens experimentally intoxicated with AFB1, using micronucleus and comet assays. The antigenotoxicity assessment of 9-day-old chicks was performed on a total of 60 chickens divided into four groups of 15 broilers each: (C) control, (P) 60 mg times piperine kg-1 feed, (A) 0.5 mg times AFB1 times kg-1 body weight, (daily by oral route), and (P + A) co-treatment with piperine and AFB1. The experiment was conducted for 26 days. Chicks intoxicated with AFB1 showed significant genotoxic effects in the first 24 h post intoxication, and the effects remained in the other periods analyzed (48, 72, and 96 h and 26 days of treatment). The DNA damage in peripheral blood cells, the number of erythrocytes with micronuclei, and polychromatic-to-normochromatic erythrocyte ratio were significantly reduced or absent in the piperine/AFB1 group. No significant differences were observed between the group piperine/AFB1 and the control and piperine-alone groups. The addition 60 mg times kg-1 of piperine to the diet of the broiler chicks was safe, promoting beneficial effects in poultry health with respect to the toxic effects 0.5 mg times AFB1 times kg-1 body weight.
language: eng
source:
identifier: E-ISSN: 2072-6651 ; DOI: 2072-6651
fulltext: fulltext
issn:
  • 20726651
  • 2072-6651
url: Link


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titleAntigenotoxic Effect of Piperine in Broiler Chickens Intoxicated with Aflatoxin B1.
creatorDa Silva Cardoso, Verônica ; Vermelho, Alane Beatriz ; Ribeiro de Lima, Cristina Amorim ; Mendes de Oliveira, Jéssica ; Freire de Lima, Marco Edilson ; Pinto Da Silva, Lúcia Helena ; Direito, Glória Maria ; Miranda Danelli, Maria Das Graças
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ispartofToxins, October 31, 2016, Vol.8(11)
identifierE-ISSN: 2072-6651 ; DOI: 2072-6651
subjectAflatoxin B1–Toxicity ; Alkaloids–Pharmacology ; Animal Feed–Pharmacology ; Animals–Pharmacology ; Anticarcinogenic Agents–Toxicity ; Benzodioxoles–Veterinary ; Carcinogens–Drug Effects ; Chickens–Pharmacology ; Comet Assay–Pharmacology ; DNA Damage–Drug Effects ; Diet–Drug Effects ; Eating–Drug Effects ; Male–Drug Effects ; Micronucleus Tests–Drug Effects ; Piperidines–Drug Effects ; Polyunsaturated Alkamides–Drug Effects ; Weight Gain–Drug Effects ; Alkaloids ; Anticarcinogenic Agents ; Benzodioxoles ; Carcinogens ; Piperidines ; Polyunsaturated Alkamides ; Aflatoxin B1 ; Piperine ; Aspergillus ; Aflatoxin B1 ; Broiler Chicken ; Piperine
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descriptionPiperine is an abundant amide extracted from black pepper seeds which has been shown to have protective effects against cytotoxic and genotoxic carcinogenesis induced by certain chemical carcinogens and aflatoxin B1 (AFB1) in vitro. The aim of this work was to study, in vivo, the antigenotoxic potential of feed-added piperine on broiler chickens experimentally intoxicated with AFB1, using micronucleus and comet assays. The antigenotoxicity assessment of 9-day-old chicks was performed on a total of 60 chickens divided into four groups of 15 broilers each: (C) control, (P) 60 mg times piperine kg-1 feed, (A) 0.5 mg times AFB1 times kg-1 body weight, (daily by oral route), and (P + A) co-treatment with piperine and AFB1. The experiment was conducted for 26 days. Chicks intoxicated with AFB1 showed significant genotoxic effects in the first 24 h post intoxication, and the effects remained in the other periods analyzed (48, 72, and 96 h and 26 days of treatment). The DNA damage in peripheral blood cells, the number of erythrocytes with micronuclei, and polychromatic-to-normochromatic erythrocyte ratio were significantly reduced or absent in the piperine/AFB1 group. No significant differences were observed between the group piperine/AFB1 and the control and piperine-alone groups. The addition 60 mg times kg-1 of piperine to the diet of the broiler chicks was safe, promoting beneficial effects in poultry health with respect to the toxic effects 0.5 mg times AFB1 times kg-1 body weight.
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titleAntigenotoxic Effect of Piperine in Broiler Chickens Intoxicated with Aflatoxin B1.
authorDa Silva Cardoso, Verônica ; Vermelho, Alane Beatriz ; Ribeiro de Lima, Cristina Amorim ; Mendes de Oliveira, Jéssica ; Freire de Lima, Marco Edilson ; Pinto Da Silva, Lúcia Helena ; Direito, Glória Maria ; Miranda Danelli, Maria Das Graças
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