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Glucocorticoid Induces Incoordination between Glutamatergic and GABAergic Neurons in the Amygdala.

BACKGROUNDStressful life leads to mood disorders. Chronic mild stress is presumably major etiology for depression, and acute severe stress leads to anxiety. These stressful situations may impair hypothalamus-pituitary-adrenal axis and in turn induce synapse dysfunction. However, it remains elusive h... Full description

Journal Title: PloS one 2016, Vol.11(11), p.e0166535
Main Author: Wang, Guang-Yan
Other Authors: Zhu, Zhao-Ming , Cui, Shan , Wang, Jin-Hui
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 1932-6203 ; DOI: 10.1371/journal.pone.0166535
Link: http://search.proquest.com/docview/1841801307/?pq-origsite=primo
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title: Glucocorticoid Induces Incoordination between Glutamatergic and GABAergic Neurons in the Amygdala.
format: Article
creator:
  • Wang, Guang-Yan
  • Zhu, Zhao-Ming
  • Cui, Shan
  • Wang, Jin-Hui
subjects:
  • Amygdala–Cytology
  • Animals–Drug Effects
  • Dexamethasone–Physiology
  • Gabaergic Neurons–Pharmacology
  • Glucocorticoids–Drug Effects
  • Glutamic Acid–Physiology
  • Membrane Potentials–Pharmacology
  • Mice–Metabolism
  • Neurons–Drug Effects
  • Receptors, Gaba–Drug Effects
  • Gamma-Aminobutyric Acid–Physiology
  • Gamma-Aminobutyric Acid–Metabolism
  • Gamma-Aminobutyric Acid–Metabolism
  • Glucocorticoids
  • Receptors, Gaba
  • Glutamic Acid
  • Gamma-Aminobutyric Acid
  • Dexamethasone
ispartof: PloS one, 2016, Vol.11(11), p.e0166535
description: BACKGROUNDStressful life leads to mood disorders. Chronic mild stress is presumably major etiology for depression, and acute severe stress leads to anxiety. These stressful situations may impair hypothalamus-pituitary-adrenal axis and in turn induce synapse dysfunction. However, it remains elusive how the stress hormones mess up subcellular compartments and interactions between excitatory and inhibitory neurons, which we have investigated in mouse amygdala, a structure related to emotional states. METHODS AND RESULTSDexamethasone was chronically given by intraperitoneal injection once a day for one week or was acutely washed into the brain slices. The neuronal spikes and synaptic transmission were recorded by whole-cell patching in amygdala neurons of brain slices. The chronic or acute administration of dexamethasone downregulates glutamate release as well as upregulates GABA release and GABAergic neuron spiking. The chronic administration of dexamethasone also enhances the responsiveness of GABA receptors. CONCLUSIONThe upregulation of GABAergic neurons and the downregulation of glutamatergic neurons by glucocorticoid impair their balance in the amygdala, which leads to emotional disorders during stress.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 1932-6203 ; DOI: 10.1371/journal.pone.0166535
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleGlucocorticoid Induces Incoordination between Glutamatergic and GABAergic Neurons in the Amygdala.
creatorWang, Guang-Yan ; Zhu, Zhao-Ming ; Cui, Shan ; Wang, Jin-Hui
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subjectAmygdala–Cytology ; Animals–Drug Effects ; Dexamethasone–Physiology ; Gabaergic Neurons–Pharmacology ; Glucocorticoids–Drug Effects ; Glutamic Acid–Physiology ; Membrane Potentials–Pharmacology ; Mice–Metabolism ; Neurons–Drug Effects ; Receptors, Gaba–Drug Effects ; Gamma-Aminobutyric Acid–Physiology ; Gamma-Aminobutyric Acid–Metabolism ; Gamma-Aminobutyric Acid–Metabolism ; Glucocorticoids ; Receptors, Gaba ; Glutamic Acid ; Gamma-Aminobutyric Acid ; Dexamethasone
descriptionBACKGROUNDStressful life leads to mood disorders. Chronic mild stress is presumably major etiology for depression, and acute severe stress leads to anxiety. These stressful situations may impair hypothalamus-pituitary-adrenal axis and in turn induce synapse dysfunction. However, it remains elusive how the stress hormones mess up subcellular compartments and interactions between excitatory and inhibitory neurons, which we have investigated in mouse amygdala, a structure related to emotional states. METHODS AND RESULTSDexamethasone was chronically given by intraperitoneal injection once a day for one week or was acutely washed into the brain slices. The neuronal spikes and synaptic transmission were recorded by whole-cell patching in amygdala neurons of brain slices. The chronic or acute administration of dexamethasone downregulates glutamate release as well as upregulates GABA release and GABAergic neuron spiking. The chronic administration of dexamethasone also enhances the responsiveness of GABA receptors. CONCLUSIONThe upregulation of GABAergic neurons and the downregulation of glutamatergic neurons by glucocorticoid impair their balance in the amygdala, which leads to emotional disorders during stress.
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titleGlucocorticoid Induces Incoordination between Glutamatergic and GABAergic Neurons in the Amygdala.
descriptionBACKGROUNDStressful life leads to mood disorders. Chronic mild stress is presumably major etiology for depression, and acute severe stress leads to anxiety. These stressful situations may impair hypothalamus-pituitary-adrenal axis and in turn induce synapse dysfunction. However, it remains elusive how the stress hormones mess up subcellular compartments and interactions between excitatory and inhibitory neurons, which we have investigated in mouse amygdala, a structure related to emotional states. METHODS AND RESULTSDexamethasone was chronically given by intraperitoneal injection once a day for one week or was acutely washed into the brain slices. The neuronal spikes and synaptic transmission were recorded by whole-cell patching in amygdala neurons of brain slices. The chronic or acute administration of dexamethasone downregulates glutamate release as well as upregulates GABA release and GABAergic neuron spiking. The chronic administration of dexamethasone also enhances the responsiveness of GABA receptors. CONCLUSIONThe upregulation of GABAergic neurons and the downregulation of glutamatergic neurons by glucocorticoid impair their balance in the amygdala, which leads to emotional disorders during stress.
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abstractBACKGROUNDStressful life leads to mood disorders. Chronic mild stress is presumably major etiology for depression, and acute severe stress leads to anxiety. These stressful situations may impair hypothalamus-pituitary-adrenal axis and in turn induce synapse dysfunction. However, it remains elusive how the stress hormones mess up subcellular compartments and interactions between excitatory and inhibitory neurons, which we have investigated in mouse amygdala, a structure related to emotional states. METHODS AND RESULTSDexamethasone was chronically given by intraperitoneal injection once a day for one week or was acutely washed into the brain slices. The neuronal spikes and synaptic transmission were recorded by whole-cell patching in amygdala neurons of brain slices. The chronic or acute administration of dexamethasone downregulates glutamate release as well as upregulates GABA release and GABAergic neuron spiking. The chronic administration of dexamethasone also enhances the responsiveness of GABA receptors. CONCLUSIONThe upregulation of GABAergic neurons and the downregulation of glutamatergic neurons by glucocorticoid impair their balance in the amygdala, which leads to emotional disorders during stress.
doi10.1371/journal.pone.0166535
urlhttp://search.proquest.com/docview/1841801307/
date2016-01-01