schliessen

Filtern

 

Bibliotheken

Intercalation-mediated nucleic acid nanoparticles for siRNA delivery

Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydr... Full description

Journal Title: Chemical Communications: Chem Comm October 2016, Vol.52(82), pp.12155-12158
Main Author: Zhou, Kejin
Other Authors: Kos, Petra , Yan, Yunfeng , Xiong, Hu , Min, Yi-Li , Kinghorn, Karina , Minnig, Jonathan , Miller, Jason , Siegwart, Daniel
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c6cc06024b
Link: http://search.proquest.com/docview/1845805140/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1845805140
title: Intercalation-mediated nucleic acid nanoparticles for siRNA delivery
format: Article
creator:
  • Zhou, Kejin
  • Kos, Petra
  • Yan, Yunfeng
  • Xiong, Hu
  • Min, Yi-Li
  • Kinghorn, Karina
  • Minnig, Jonathan
  • Miller, Jason
  • Siegwart, Daniel
subjects:
  • Carriers
  • Ribonucleic Acids
  • Current Carriers
  • Stability
  • Nanoparticles
  • Nucleic Acids
  • Nanostructure
  • Interaction Parameters
  • Miscellaneous Sciences (So)
  • Chemical and Electrochemical Properties (MD)
  • Chemical and Electrochemical Properties (Ep)
  • Chemical and Electrochemical Properties (Ed)
  • Chemical and Electrochemical Properties (EC)
ispartof: Chemical Communications: Chem Comm, October 2016, Vol.52(82), pp.12155-12158
description: Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.
language: eng
source:
identifier: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c6cc06024b
fulltext: fulltext
issn:
  • 13597345
  • 1359-7345
  • 1364548X
  • 1364-548X
url: Link


@attributes
ID874730587
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1845805140
sourceidproquest
recordidTN_proquest1845805140
sourcesystemPC
pqid1845805140
display
typearticle
titleIntercalation-mediated nucleic acid nanoparticles for siRNA delivery
creatorZhou, Kejin ; Kos, Petra ; Yan, Yunfeng ; Xiong, Hu ; Min, Yi-Li ; Kinghorn, Karina ; Minnig, Jonathan ; Miller, Jason ; Siegwart, Daniel
contributorZhou, Kejin (correspondence author)
ispartofChemical Communications: Chem Comm, October 2016, Vol.52(82), pp.12155-12158
identifier
subjectCarriers ; Ribonucleic Acids ; Current Carriers ; Stability ; Nanoparticles ; Nucleic Acids ; Nanostructure ; Interaction Parameters ; Miscellaneous Sciences (So) ; Chemical and Electrochemical Properties (MD) ; Chemical and Electrochemical Properties (Ep) ; Chemical and Electrochemical Properties (Ed) ; Chemical and Electrochemical Properties (EC)
descriptionTremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.
languageeng
source
version6
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1845805140/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Zhou, Kejin
1Kos, Petra
2Yan, Yunfeng
3Xiong, Hu
4Min, Yi-Li
5Kinghorn, Karina
6Minnig, Jonathan
7Miller, Jason
8Siegwart, Daniel
titleIntercalation-mediated nucleic acid nanoparticles for siRNA delivery
descriptionTremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.
subject
0Carriers
1Ribonucleic Acids
2Current Carriers
3Stability
4Nanoparticles
5Nucleic Acids
6Nanostructure
7Interaction Parameters
8Miscellaneous Sciences (So)
9Chemical and Electrochemical Properties (MD)
10Chemical and Electrochemical Properties (Ep)
11Chemical and Electrochemical Properties (Ed)
12Chemical and Electrochemical Properties (EC)
1316
1434
15C4
general
0English
110.1039/c6cc06024b
2Engineered Materials Abstracts
3Solid State and Superconductivity Abstracts
4METADEX
5Advanced Technologies Database with Aerospace
6Materials Research Database
7Technology Research Database
8ProQuest Advanced Technologies & Aerospace Collection
9ProQuest Materials Science Collection
10ProQuest Technology Collection
11ProQuest SciTech Collection
12Advanced Technologies & Aerospace Database
13Materials Science & Engineering Database
14SciTech Premium Collection
15Technology Collection
sourceidproquest
recordidproquest1845805140
issn
013597345
11359-7345
21364548X
31364-548X
rsrctypearticle
creationdate2016
addtitleChemical Communications: Chem Comm
searchscope
01007393
11007481
21007528
31007944
410000012
510000014
610000015
710000022
810000045
910000049
1010000053
1110000120
1210000195
1310000201
1410000203
1510000209
1610000233
1710000250
1810000260
1910000265
20proquest
scope
01007393
11007481
21007528
31007944
410000012
510000014
610000015
710000022
810000045
910000049
1010000053
1110000120
1210000195
1310000201
1410000203
1510000209
1610000233
1710000250
1810000260
1910000265
20proquest
lsr43
01007393false
11007481false
21007528false
31007944false
410000012false
510000014false
610000015false
710000022false
810000045false
910000049false
1010000053false
1110000120false
1210000195false
1310000201false
1410000203false
1510000209false
1610000233false
1710000250false
1810000260false
1910000265false
contributorZhou, Kejin
startdate20161001
enddate20161001
citationpf 12155 pt 12158 vol 52 issue 82
lsr30VSR-Enriched:[pqid]
sort
titleIntercalation-mediated nucleic acid nanoparticles for siRNA delivery
authorZhou, Kejin ; Kos, Petra ; Yan, Yunfeng ; Xiong, Hu ; Min, Yi-Li ; Kinghorn, Karina ; Minnig, Jonathan ; Miller, Jason ; Siegwart, Daniel
creationdate20161001
lso0120161001
facets
frbrgroupid8780426120026651311
frbrtype5
newrecords20170309
languageeng
creationdate2016
topic
0Carriers
1Ribonucleic Acids
2Current Carriers
3Stability
4Nanoparticles
5Nucleic Acids
6Nanostructure
7Interaction Parameters
8Miscellaneous Sciences (So)
9Chemical and Electrochemical Properties (MD)
10Chemical and Electrochemical Properties (Ep)
11Chemical and Electrochemical Properties (Ed)
12Chemical and Electrochemical Properties (EC)
collection
0Engineered Materials Abstracts
1Solid State and Superconductivity Abstracts
2METADEX
3Advanced Technologies Database with Aerospace
4Materials Research Database
5Technology Research Database
6ProQuest Advanced Technologies & Aerospace Collection
7ProQuest Materials Science Collection
8ProQuest Technology Collection
9ProQuest SciTech Collection
10Advanced Technologies & Aerospace Database
11Materials Science & Engineering Database
12SciTech Premium Collection
13Technology Collection
prefilterarticles
rsrctypearticles
creatorcontrib
0Zhou, Kejin
1Kos, Petra
2Yan, Yunfeng
3Xiong, Hu
4Min, Yi-Li
5Kinghorn, Karina
6Minnig, Jonathan
7Miller, Jason
8Siegwart, Daniel
jtitleChemical Communications: Chem Comm
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Zhou
1Kos
2Yan
3Xiong
4Min
5Kinghorn
6Minnig
7Miller
8Siegwart
aufirst
0Kejin
1Petra
2Yunfeng
3Hu
4Yi-Li
5Karina
6Jonathan
7Jason
8Daniel
au
0Zhou, Kejin
1Kos, Petra
2Yan, Yunfeng
3Xiong, Hu
4Min, Yi-Li
5Kinghorn, Karina
6Minnig, Jonathan
7Miller, Jason
8Siegwart, Daniel
addauZhou, Kejin
atitleIntercalation-mediated nucleic acid nanoparticles for siRNA delivery
jtitleChemical Communications: Chem Comm
risdate20161001
volume52
issue82
spage12155
epage12158
pages12155-12158
issn1359-7345
eissn1364-548X
formatjournal
genrearticle
ristypeJOUR
abstractTremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery. This toolbox expansion of interaction parameters may inspire the use of additional forces in nanoparticle drug carriers to increase potency and stability.
doi10.1039/c6cc06024b
urlhttp://search.proquest.com/docview/1845805140/
date2016-10-01