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Keratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis.

Backround: Steatohepatitis (SH)-associated liver carcinogenesis is an increasingly important issue in clinical medicine. SH is morphologically characterized by steatosis, hepatocyte injury, ballooning, hepatocytic cytoplasmic inclusions termed Mallory-Denk bodies (MDBs), inflammation and fibrosis. R... Full description

Journal Title: Oncotarget November 8, 2016, Vol.7(45), pp.73309-73322
Main Author: Bettermann, Kira
Other Authors: Mehta, Anita Kuldeep , Hofer, Eva M , Wohlrab, Christina , Golob-Schwarzl, Nicole , Svendova, Vendula , Schimek, Michael G , Stumptner, Cornelia , Thüringer, Andrea , Speicher, Michael R , Lackner, Carolin , Zatloukal, Kurt , Denk, Helmut , Haybaeck, Johannes
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.12325
Link: http://search.proquest.com/docview/1857378054/?pq-origsite=primo
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title: Keratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis.
format: Article
creator:
  • Bettermann, Kira
  • Mehta, Anita Kuldeep
  • Hofer, Eva M
  • Wohlrab, Christina
  • Golob-Schwarzl, Nicole
  • Svendova, Vendula
  • Schimek, Michael G
  • Stumptner, Cornelia
  • Thüringer, Andrea
  • Speicher, Michael R
  • Lackner, Carolin
  • Zatloukal, Kurt
  • Denk, Helmut
  • Haybaeck, Johannes
subjects:
  • Animals–Complications
  • Cell Transformation, Neoplastic–Genetics
  • Chromosome Aberrations–Methods
  • Comparative Genomic Hybridization–Deficiency
  • Disease Models, Animal–Genetics
  • Fatty Liver–Etiology
  • Genomics–Pathology
  • Immunohistochemistry–Pathology
  • Keratin-18–Pathology
  • Liver Neoplasms–Pathology
  • Male–Pathology
  • Mice–Pathology
  • Mice, Knockout–Pathology
  • Phenotype–Pathology
  • Keratin-18
  • Mallory-Denk Bodies
  • Keratin 18 Deficiency
  • Liver Tumors
  • Steatohepatitis
ispartof: Oncotarget, November 8, 2016, Vol.7(45), pp.73309-73322
description: Backround: Steatohepatitis (SH)-associated liver carcinogenesis is an increasingly important issue in clinical medicine. SH is morphologically characterized by steatosis, hepatocyte injury, ballooning, hepatocytic cytoplasmic inclusions termed Mallory-Denk bodies (MDBs), inflammation and fibrosis. RESULTS17-20-months-old Krt18-/- and Krt18+/- mice in contrast to wt mice spontaneously developed liver lesions closely resembling the morphological spectrum of human SH as well as liver tumors. The pathologic alterations were more pronounced in Krt18-/- than in Krt18+/- mice. The frequency of liver tumors with male predominance was significantly higher in Krt18-/- compared to age-matched Krt18+/- and wt mice. Krt18-deficient tumors in contrast to wt animals displayed SH features and often pleomorphic morphology. aCGH analysis of tumors revealed chromosomal aberrations in Krt18-/- liver tumors, affecting loci of oncogenes and tumor suppressor genes. MATERIALS AND METHODSLivers of 3-, 6-, 12- and...
language: eng
source:
identifier: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.12325
fulltext: fulltext
issn:
  • 19492553
  • 1949-2553
url: Link


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titleKeratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis.
creatorBettermann, Kira ; Mehta, Anita Kuldeep ; Hofer, Eva M ; Wohlrab, Christina ; Golob-Schwarzl, Nicole ; Svendova, Vendula ; Schimek, Michael G ; Stumptner, Cornelia ; Thüringer, Andrea ; Speicher, Michael R ; Lackner, Carolin ; Zatloukal, Kurt ; Denk, Helmut ; Haybaeck, Johannes
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ispartofOncotarget, November 8, 2016, Vol.7(45), pp.73309-73322
identifierE-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.12325
subjectAnimals–Complications ; Cell Transformation, Neoplastic–Genetics ; Chromosome Aberrations–Methods ; Comparative Genomic Hybridization–Deficiency ; Disease Models, Animal–Genetics ; Fatty Liver–Etiology ; Genomics–Pathology ; Immunohistochemistry–Pathology ; Keratin-18–Pathology ; Liver Neoplasms–Pathology ; Male–Pathology ; Mice–Pathology ; Mice, Knockout–Pathology ; Phenotype–Pathology ; Keratin-18 ; Mallory-Denk Bodies ; Keratin 18 Deficiency ; Liver Tumors ; Steatohepatitis
descriptionBackround: Steatohepatitis (SH)-associated liver carcinogenesis is an increasingly important issue in clinical medicine. SH is morphologically characterized by steatosis, hepatocyte injury, ballooning, hepatocytic cytoplasmic inclusions termed Mallory-Denk bodies (MDBs), inflammation and fibrosis. RESULTS17-20-months-old Krt18-/- and Krt18+/- mice in contrast to wt mice spontaneously developed liver lesions closely resembling the morphological spectrum of human SH as well as liver tumors. The pathologic alterations were more pronounced in Krt18-/- than in Krt18+/- mice. The frequency of liver tumors with male predominance was significantly higher in Krt18-/- compared to age-matched Krt18+/- and wt mice. Krt18-deficient tumors in contrast to wt animals displayed SH features and often pleomorphic morphology. aCGH analysis of tumors revealed chromosomal aberrations in Krt18-/- liver tumors, affecting loci of oncogenes and tumor suppressor genes. MATERIALS AND METHODSLivers of 3-, 6-, 12- and...
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titleKeratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis.
descriptionBackround: Steatohepatitis (SH)-associated liver carcinogenesis is an increasingly important issue in clinical medicine. SH is morphologically characterized by steatosis, hepatocyte injury, ballooning, hepatocytic cytoplasmic inclusions termed Mallory-Denk bodies (MDBs), inflammation and fibrosis. RESULTS17-20-months-old Krt18-/- and Krt18+/- mice in contrast to wt mice spontaneously developed liver lesions closely resembling the morphological spectrum of human SH as well as liver tumors. The pathologic alterations were more pronounced in Krt18-/- than in Krt18+/- mice. The frequency of liver tumors with male predominance was significantly higher in Krt18-/- compared to age-matched Krt18+/- and wt mice. Krt18-deficient tumors in contrast to wt animals displayed SH features and often pleomorphic morphology. aCGH analysis of tumors revealed chromosomal aberrations in Krt18-/- liver tumors, affecting loci of oncogenes and tumor suppressor genes. MATERIALS AND METHODSLivers of 3-, 6-, 12- and...
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titleKeratin 18-deficiency results in steatohepatitis and liver tumors in old mice: A model of steatohepatitis-associated liver carcinogenesis.
authorBettermann, Kira ; Mehta, Anita Kuldeep ; Hofer, Eva M ; Wohlrab, Christina ; Golob-Schwarzl, Nicole ; Svendova, Vendula ; Schimek, Michael G ; Stumptner, Cornelia ; Thüringer, Andrea ; Speicher, Michael R ; Lackner, Carolin ; Zatloukal, Kurt ; Denk, Helmut ; Haybaeck, Johannes
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abstractBackround: Steatohepatitis (SH)-associated liver carcinogenesis is an increasingly important issue in clinical medicine. SH is morphologically characterized by steatosis, hepatocyte injury, ballooning, hepatocytic cytoplasmic inclusions termed Mallory-Denk bodies (MDBs), inflammation and fibrosis. RESULTS17-20-months-old Krt18-/- and Krt18+/- mice in contrast to wt mice spontaneously developed liver lesions closely resembling the morphological spectrum of human SH as well as liver tumors. The pathologic alterations were more pronounced in Krt18-/- than in Krt18+/- mice. The frequency of liver tumors with male predominance was significantly higher in Krt18-/- compared to age-matched Krt18+/- and wt mice. Krt18-deficient tumors in contrast to wt animals displayed SH features and often pleomorphic morphology. aCGH analysis of tumors revealed chromosomal aberrations in Krt18-/- liver tumors, affecting loci of oncogenes and tumor suppressor genes. MATERIALS AND METHODSLivers of 3-, 6-, 12- and...
doi10.18632/oncotarget.12325
urlhttp://search.proquest.com/docview/1857378054/
date2016-11-08