schliessen

Filtern

 

Bibliotheken

Integrated genomic and molecular characterization of cervical cancer.

Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary cervical cancers, one of the largest comprehensive genomic studies of cervical cancer to date. We observed notable APOBEC mutagenesis patterns... Full description

Journal Title: Nature March 16, 2017, Vol.543(7645), pp.378-384
Main Author: Burk, Robert D
Other Authors: Chen, Zigui , Saller, Charles , Tarvin, Katherine , Carvalho, Andre L , Scapulatempo-Neto, Cristovam , Silveira, Henrique C , Fregnani, José H , Creighton, Chad J , Anderson, Matthew L , Castro, Patricia , Wang, Sophia S , Yau, Christina , Benz, Christopher , Robertson, A Gordon , Mungall, Karen , Lim, Lynette , Bowlby, Reanne , Sadeghi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1476-4687 ; DOI: 10.1038/nature21386
Link: http://search.proquest.com/docview/1861597110/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1861597110
title: Integrated genomic and molecular characterization of cervical cancer.
format: Article
creator:
  • Burk, Robert D
  • Chen, Zigui
  • Saller, Charles
  • Tarvin, Katherine
  • Carvalho, Andre L
  • Scapulatempo-Neto, Cristovam
  • Silveira, Henrique C
  • Fregnani, José H
  • Creighton, Chad J
  • Anderson, Matthew L
  • Castro, Patricia
  • Wang, Sophia S
  • Yau, Christina
  • Benz, Christopher
  • Robertson, A Gordon
  • Mungall, Karen
  • Lim, Lynette
  • Bowlby, Reanne
  • Sadeghi
subjects:
  • Apobec-1 Deaminase–Genetics
  • Adenocarcinoma–Genetics
  • B7-H1 Antigen–Genetics
  • Carcinoma, Squamous Cell–Genetics
  • Caspase 8–Genetics
  • Female–Genetics
  • Genomics–Genetics
  • HLA-A Antigens–Isolation & Purification
  • Human Papillomavirus 16–Genetics
  • Humans–Metabolism
  • Keratins–Genetics
  • Mitogen-Activated Protein Kinase Kinases–Genetics
  • Molecular Targeted Therapy–Metabolism
  • Mutation–Genetics
  • Nuclear Proteins–Genetics
  • Pten Phosphohydrolase–Metabolism
  • Phosphatidylinositol 3-Kinases–Genetics
  • Programmed Cell Death 1 Ligand 2 Protein–Genetics
  • Protein-Serine-Threonine Kinases
ispartof: Nature, March 16, 2017, Vol.543(7645), pp.378-384
description: Cervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary cervical cancers, one of the largest comprehensive genomic studies of cervical cancer to date. We observed notable APOBEC mutagenesis patterns and identified SHKBP1, ERBB3, CASP8, HLA-A and TGFBR2 as novel significantly mutated genes in cervical cancer. We also discovered amplifications in immune targets CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2), and the BCAR4 long non-coding RNA, which has been associated with response to lapatinib. Integration of human papilloma virus (HPV) was observed in all HPV18-related samples and 76% of HPV16-related samples, and was associated with structural aberrations and increased target-gene expression. We identified a unique set of endometrial-like cervical cancers, comprised predominantly of HPV-negative tumours with relatively high frequencies of KRAS, ARID1A and PTEN mutations. Integrative clustering of 178 samples identified keratin-low squamous, keratin-high squamous and adenocarcinoma-rich subgroups. These molecular analyses reveal new potential therapeutic targets for cervical cancers.
language: eng
source:
identifier: E-ISSN: 1476-4687 ; DOI: 10.1038/nature21386
fulltext: fulltext
issn:
  • 14764687
  • 1476-4687
url: Link


@attributes
ID285159329
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1861597110
sourceidproquest
recordidTN_proquest1861597110
sourcesystemPC
pqid1861597110
galeid485686504
display
typearticle
titleIntegrated genomic and molecular characterization of cervical cancer.
creatorBurk, Robert D ; Chen, Zigui ; Saller, Charles ; Tarvin, Katherine ; Carvalho, Andre L ; Scapulatempo-Neto, Cristovam ; Silveira, Henrique C ; Fregnani, José H ; Creighton, Chad J ; Anderson, Matthew L ; Castro, Patricia ; Wang, Sophia S ; Yau, Christina ; Benz, Christopher ; Robertson, A Gordon ; Mungall, Karen ; Lim, Lynette ; Bowlby, Reanne ; Sadeghi
contributorIacocca, Mary (record owner) ; Petrelli, Nicholas ; Swanson, Patricia ; Ojesina, Akinyemi I ; Le, Xuan ; Sandusky, George ; Adebamowo, Sally N ; Akeredolu, Teniola ; Adebamowo, Clement ; Reynolds, Sheila M ; Shmulevich, Ilya ; Shelton, Candace ; Crain, Daniel ; Mallery, David ; Curley, Erin ; Gardner, Johanna ; Penny, Robert ; Morris, Scott ; Shelton, Troy ; Liu
ispartofNature, March 16, 2017, Vol.543(7645), pp.378-384
identifierE-ISSN: 1476-4687 ; DOI: 10.1038/nature21386
subjectApobec-1 Deaminase–Genetics ; Adenocarcinoma–Genetics ; B7-H1 Antigen–Genetics ; Carcinoma, Squamous Cell–Genetics ; Caspase 8–Genetics ; Female–Genetics ; Genomics–Genetics ; HLA-A Antigens–Isolation & Purification ; Human Papillomavirus 16–Genetics ; Humans–Metabolism ; Keratins–Genetics ; Mitogen-Activated Protein Kinase Kinases–Genetics ; Molecular Targeted Therapy–Metabolism ; Mutation–Genetics ; Nuclear Proteins–Genetics ; Pten Phosphohydrolase–Metabolism ; Phosphatidylinositol 3-Kinases–Genetics ; Programmed Cell Death 1 Ligand 2 Protein–Genetics ; Protein-Serine-Threonine Kinases
languageeng
source
descriptionCervical cancer remains one of the leading causes of cancer-related deaths worldwide. Here we report the extensive molecular characterization of 228 primary cervical cancers, one of the largest comprehensive genomic studies of cervical cancer to date. We observed notable APOBEC mutagenesis patterns and identified SHKBP1, ERBB3, CASP8, HLA-A and TGFBR2 as novel significantly mutated genes in cervical cancer. We also discovered amplifications in immune targets CD274 (also known as PD-L1) and PDCD1LG2 (also known as PD-L2), and the BCAR4 long non-coding RNA, which has been associated with response to lapatinib. Integration of human papilloma virus (HPV) was observed in all HPV18-related samples and 76% of HPV16-related samples, and was associated with structural aberrations and increased target-gene expression. We identified a unique set of endometrial-like cervical cancers, comprised predominantly of HPV-negative tumours with relatively high frequencies of KRAS, ARID1A and PTEN mutations. Integrative clustering of 178 samples identified keratin-low squamous, keratin-high squamous and adenocarcinoma-rich subgroups. These molecular analyses reveal new potential therapeutic targets for cervical cancers.
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1861597110/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Burk, Robert D
1Chen, Zigui
2Saller, Charles
3Tarvin, Katherine
4Carvalho, Andre L
5Scapulatempo-Neto, Cristovam
6Silveira, Henrique C
7Fregnani, José H
8Creighton, Chad J
9Anderson, Matthew L
10Castro, Patricia
11Wang, Sophia S
12Yau, Christina
13Benz, Christopher
14Robertson, A Gordon
15Mungall, Karen
16Lim, Lynette
17Bowlby, Reanne
18Sadeghi, Sara
19Brooks, Denise
20Sipahimalani, Payal
21Mar, Richard
22Ally, Adrian
23Clarke, Amanda
24Mungall, Andrew J
25Tam, Angela
26Lee, Darlene
27Chuah, Eric
28Schein, Jacqueline E
29Tse, Kane
30Kasaian, Katayoon
31Ma, Yussanne
32Marra, Marco A
33Mayo, Michael
34Balasundaram, Miruna
35Thiessen, Nina
36Dhalla, Noreen
37Carlsen, Rebecca
38Moore, Richard A
39Holt, Robert A
40Jones, Steven J M
41Wong, Tina
42Pantazi, Angeliki
43Parfenov, Michael
44Kucherlapati, Raju
45Hadjipanayis, Angela
46Seidman, Jonathan
47Kucherlapati, Melanie
48Ren, Xiaojia
49Xu, Andrew W
50Yang, Lixing
51Park, Peter J
52Lee, Semin
53Rabeno, Brenda
54Huelsenbeck-Dill, Lori
55Borowsky, Mark
56Cadungog, Mark
titleIntegrated genomic and molecular characterization of cervical cancer.
subject
0Apobec-1 Deaminase–Genetics
1Adenocarcinoma–Genetics
2B7-H1 Antigen–Genetics
3Carcinoma, Squamous Cell–Genetics
4Caspase 8–Genetics
5Female–Genetics
6Genomics–Genetics
7HLA-A Antigens–Isolation & Purification
8Human Papillomavirus 16–Genetics
9Humans–Metabolism
10Keratins–Genetics
11Mitogen-Activated Protein Kinase Kinases–Genetics
12Molecular Targeted Therapy–Metabolism
13Mutation–Genetics
14Nuclear Proteins–Genetics
15Pten Phosphohydrolase–Metabolism
16Phosphatidylinositol 3-Kinases–Genetics
17Programmed Cell Death 1 Ligand 2 Protein–Genetics
18Protein-Serine-Threonine Kinases
general
0English
110.1038/nature21386
2MEDLINE (ProQuest)
3ProQuest Biological Science Collection
4ProQuest Environmental Science Collection
5ProQuest Natural Science Collection
6ProQuest SciTech Collection
7Agricultural & Environmental Science Database
8Biological Science Database
9Natural Science Collection
10SciTech Premium Collection
11Health Research Premium Collection
12Health Research Premium Collection (Alumni edition)
13Environmental Science Index (ProQuest)
14Biological Science Index (ProQuest)
15Environmental Science Collection (ProQuest)
sourceidproquest
recordidproquest1861597110
issn
014764687
11476-4687
rsrctypearticle
creationdate2017
addtitleNature
searchscope
01007489
11007527
21007944
31009130
410000004
510000006
610000038
710000043
810000050
910000120
1010000159
1110000198
1210000200
1310000209
1410000217
1510000234
1610000238
1710000253
1810000260
1910000270
2010000271
2110000302
2210000349
2310000350
2410000354
25proquest
scope
01007489
11007527
21007944
31009130
410000004
510000006
610000038
710000043
810000050
910000120
1010000159
1110000198
1210000200
1310000209
1410000217
1510000234
1610000238
1710000253
1810000260
1910000270
2010000271
2110000302
2210000349
2310000350
2410000354
25proquest
lsr43
01007489false
11007527false
21007944false
31009130false
410000004false
510000006false
610000038false
710000043false
810000050false
910000120false
1010000159false
1110000198false
1210000200false
1310000209false
1410000217false
1510000234false
1610000238false
1710000253false
1810000260false
1910000270false
2010000271false
2110000302false
2210000349false
2310000350false
2410000354false
contributor
0Iacocca, Mary
1Petrelli, Nicholas
2Swanson, Patricia
3Ojesina, Akinyemi I
4Le, Xuan
5Sandusky, George
6Adebamowo, Sally N
7Akeredolu, Teniola
8Adebamowo, Clement
9Reynolds, Sheila M
10Shmulevich, Ilya
11Shelton, Candace
12Crain, Daniel
13Mallery, David
14Curley, Erin
15Gardner, Johanna
16Penny, Robert
17Morris, Scott
18Shelton, Troy
19Liu, Jia
20Lolla, Laxmi
21Chudamani, Sudha
22Wu, Ye
23Birrer, Michael
24Mclellan, Michael D
25Bailey, Matthew H
26Miller, Christopher A
27Wyczalkowski, Matthew A
28Fulton, Robert S
29Fronick, Catrina C
30Lu, Charles
31Mardis, Elaine R
32Appelbaum, Elizabeth L
33Schmidt, Heather K
34Fulton, Lucinda A
35Cordes, Matthew G
36Li, Tiandao
37Ding, Li
38Wilson, Richard K
39Rader, Janet S
40Behmaram, Behnaz
41Uyar, Denise
42Bradley, William
43Wrangle, John
44Pastore, Alessandro
45Levine, Douglas A
46Dao, Fanny
47Gao, Jianjiong
48Schultz, Nikolaus
49Sander, Chris
50Ladanyi, Marc
51Einstein, Mark
52Teeter, Randall
53Benz, Stephen
54Wentzensen, Nicolas
55Felau, Ina
56Zenklusen, Jean C
57Bodelon, Clara
58Demchok, John A
59Yang, Liming
60Sheth, Margi
61Ferguson, Martin L
62Tarnuzzer, Roy
63Yang, Hannah
64Schiffman, Mark
65Zhang, Jiashan
66Wang, Zhining
67Davidsen, Tanja
68Olaniyan, Olayinka
69Hutter, Carolyn M
70Sofia, Heidi J
71Gordenin, Dmitry A
72Chan, Kin
73Roberts, Steven A
74Klimczak, Leszek J
75Van Waes, Carter
76Chen, Zhong
77Saleh, Anthony D
78Cheng, Hui
79Parfitt, Jeremy
80Bartlett, John
81Albert, Monique
82Arnaout, Angel
83Sekhon, Harman
84Gilbert, Sebastien
85Peto, Myron
86Myers, Jerome
87Harr, Jodi
88Eckman, John
89Bergsten, Julie
90Tucker, Kelinda
91Zach, Leigh Anne
92Karlan, Beth Y
93Lester, Jenny
94Orsulic, Sandra
95Sun, Qiang
96Naresh, Rashi
97Pihl, Todd
98Wan, Yunhu
99Zaren, Howard
100...
startdate20170316
enddate20170316
citationpf 378 pt 384 vol 543 issue 7645
lsr30VSR-Enriched:[pqid, issn, galeid, description]
sort
titleIntegrated genomic and molecular characterization of cervical cancer.
authorBurk, Robert D ; Chen, Zigui ; Saller, Charles ; Tarvin, Katherine ; Carvalho, Andre L ; Scapulatempo-Neto, Cristovam ; Silveira, Henrique C ; Fregnani, José H ; Creighton, Chad J ; Anderson, Matthew L ; Castro, Patricia ; Wang, Sophia S ; Yau, Christina ; Benz, Christopher ; Robertson, A Gordon ; Mungall, Karen ; Lim, Lynette ; Bowlby, Reanne ; Sadeghi
creationdate20170316
lso0120170316
facets
frbrgroupid6149089471199921079
frbrtype5
newrecords20181218
languageeng
creationdate2017
topic
0Apobec-1 Deaminase–Genetics
1Adenocarcinoma–Genetics
2B7-H1 Antigen–Genetics
3Carcinoma, Squamous Cell–Genetics
4Caspase 8–Genetics
5Female–Genetics
6Genomics–Genetics
7HLA-A Antigens–Isolation & Purification
8Human Papillomavirus 16–Genetics
9Humans–Metabolism
10Keratins–Genetics
11Mitogen-Activated Protein Kinase Kinases–Genetics
12Molecular Targeted Therapy–Metabolism
13Mutation–Genetics
14Nuclear Proteins–Genetics
15Pten Phosphohydrolase–Metabolism
16Phosphatidylinositol 3-Kinases–Genetics
17Programmed Cell Death 1 Ligand 2 Protein–Genetics
18Protein-Serine-Threonine Kinases
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Environmental Science Collection
3ProQuest Natural Science Collection
4ProQuest SciTech Collection
5Agricultural & Environmental Science Database
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
11Environmental Science Index (ProQuest)
12Biological Science Index (ProQuest)
13Environmental Science Collection (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0Burk, Robert D
1Chen, Zigui
2Saller, Charles
3Tarvin, Katherine
4Carvalho, Andre L
5Scapulatempo-Neto, Cristovam
6Silveira, Henrique C
7Fregnani, José H
8Creighton, Chad J
9Anderson, Matthew L
10Castro, Patricia
11Wang, Sophia S
12Yau, Christina
13Benz, Christopher
14Robertson, A Gordon
15Mungall, Karen
16Lim, Lynette
17Bowlby, Reanne
18Sadeghi, Sara
19Brooks, Denise
20Sipahimalani, Payal
21Mar, Richard
22Ally, Adrian
23Clarke, Amanda
24Mungall, Andrew J
25Tam, Angela
26Lee, Darlene
27Chuah, Eric
28Schein, Jacqueline E
29Tse, Kane
30Kasaian, Katayoon
31Ma, Yussanne
32Marra, Marco A
33Mayo, Michael
34Balasundaram, Miruna
35Thiessen, Nina
36Dhalla, Noreen
37Carlsen, Rebecca
38Moore, Richard A
39Holt, Robert A
40Jones, Steven J M
41Wong, Tina
42Pantazi, Angeliki
43Parfenov, Michael
44Kucherlapati, Raju
45Hadjipanayis, Angela
46Seidman, Jonathan
47Kucherlapati, Melanie
48Ren, Xiaojia
49Xu, Andrew W
50Yang, Lixing
51Park, Peter J
52Lee, Semin
53Rabeno, Brenda
54Huelsenbeck-Dill, Lori
55Borowsky, Mark
56Cadungog, Mark
57Iacocca, Mary
58Petrelli, Nicholas
59Swanson, Patricia
60Ojesina, Akinyemi I
61Le, Xuan
62Sandusky, George
63Adebamowo, Sally N
64Akeredolu, Teniola
65Adebamowo, Clement
66Reynolds, Sheila M
67Shmulevich, Ilya
68Shelton, Candace
69Crain, Daniel
70Mallery, David
71Curley, Erin
72Gardner, Johanna
73Penny, Robert
74Morris, Scott
75Shelton, Troy
76Liu, Jia
77Lolla, Laxmi
78Chudamani, Sudha
79Wu, Ye
80Birrer, Michael
81Mclellan, Michael D
82Bailey, Matthew H
83Miller, Christopher A
84Wyczalkowski, Matthew A
85Fulton, Robert S
86Fronick, Catrina C
87Lu, Charles
88Mardis, Elaine R
89Appelbaum, Elizabeth L
90Schmidt, Heather K
91Fulton, Lucinda A
92Cordes, Matthew G
93Li, Tiandao
94Ding, Li
95Wilson, Richard K
96Rader, Janet S
97Behmaram, Behnaz
98Uyar, Denise
99Bradley, William
100...
jtitleNature
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Burk
1Chen
2Saller
3Tarvin
4Carvalho
5Scapulatempo-Neto
6Silveira
7Fregnani
8Creighton
9Anderson
10Castro
11Wang
12Yau
13Benz
14Robertson
15Mungall
16Lim
17Bowlby
18Sadeghi
19Brooks
20Sipahimalani
21Mar
22Ally
23Clarke
24Tam
25Lee
26Chuah
27Schein
28Tse
29Kasaian
30Ma
31Marra
32Mayo
33Balasundaram
34Thiessen
35Dhalla
36Carlsen
37Moore
38Holt
39Jones
40Wong
41Pantazi
42Parfenov
43Kucherlapati
44Hadjipanayis
45Seidman
46Ren
47Xu
48Yang
49Park
50Rabeno
51Huelsenbeck-Dill
52Borowsky
53Cadungog
aufirst
0Robert D
1Zigui
2Charles
3Katherine
4Andre L
5Cristovam
6Henrique C
7José H
8Chad J
9Matthew L
10Patricia
11Sophia S
12Christina
13Christopher
14A Gordon
15Karen
16Lynette
17Reanne
18Sara
19Denise
20Payal
21Richard
22Adrian
23Amanda
24Andrew J
25Angela
26Darlene
27Eric
28Jacqueline E
29Kane
30Katayoon
31Yussanne
32Marco A
33Michael
34Miruna
35Nina
36Noreen
37Rebecca
38Richard A
39Robert A
40Steven J M
41Tina
42Angeliki
43Raju
44Jonathan
45Melanie
46Xiaojia
47Andrew W
48Lixing
49Peter J
50Semin
51Brenda
52Lori
53Mark
au
0Burk, Robert D
1Chen, Zigui
2Saller, Charles
3Tarvin, Katherine
4Carvalho, Andre L
5Scapulatempo-Neto, Cristovam
6Silveira, Henrique C
7Fregnani, José H
8Creighton, Chad J
9Anderson, Matthew L
10Castro, Patricia
11Wang, Sophia S
12Yau, Christina
13Benz, Christopher
14Robertson, A Gordon
15Mungall, Karen
16Lim, Lynette
17Bowlby, Reanne
18Sadeghi, Sara
19Brooks, Denise
20Sipahimalani, Payal
21Mar, Richard
22Ally, Adrian
23Clarke, Amanda
24Mungall, Andrew J
25Tam, Angela
26Lee, Darlene
27Chuah, Eric
28Schein, Jacqueline E
29Tse, Kane
30Kasaian, Katayoon
31Ma, Yussanne
32Marra, Marco A
33Mayo, Michael
34Balasundaram, Miruna
35Thiessen, Nina
36Dhalla, Noreen
37Carlsen, Rebecca
38Moore, Richard A
39Holt, Robert A
40Jones, Steven J M
41Wong, Tina
42Pantazi, Angeliki
43Parfenov, Michael
44Kucherlapati, Raju
45Hadjipanayis, Angela
46Seidman, Jonathan
47Kucherlapati, Melanie
48Ren, Xiaojia
49Xu, Andrew W
50Yang, Lixing
51Park, Peter J
52Lee, Semin
53Rabeno, Brenda
54Huelsenbeck-Dill, Lori
55Borowsky, Mark
56Cadungog, Mark
addau
0Iacocca, Mary
1Petrelli, Nicholas
2Swanson, Patricia
3Ojesina, Akinyemi I
4Le, Xuan
5Sandusky, George
6Adebamowo, Sally N
7Akeredolu, Teniola
8Adebamowo, Clement
9Reynolds, Sheila M
10Shmulevich, Ilya
11Shelton, Candace
12Crain, Daniel
13Mallery, David
14Curley, Erin
15Gardner, Johanna
16Penny, Robert
17Morris, Scott
18Shelton, Troy
19Liu, Jia
20Lolla, Laxmi
21Chudamani, Sudha
22Wu, Ye
23Birrer, Michael
24McLellan, Michael D
25Bailey, Matthew H
26Miller, Christopher A
27Wyczalkowski, Matthew A
28Fulton, Robert S
29Fronick, Catrina C
30Lu, Charles
31Mardis, Elaine R
32Appelbaum, Elizabeth L
33Schmidt, Heather K
34Fulton, Lucinda A
35Cordes, Matthew G
36Li, Tiandao
37Ding, Li
38Wilson, Richard K
39Rader, Janet S
40Behmaram, Behnaz
41Uyar, Denise
42Bradley, William
43Wrangle, John
44Pastore, Alessandro
45Levine, Douglas A
46Dao, Fanny
47Gao, Jianjiong
48Schultz, Nikolaus
49Sander, Chris
50Ladanyi, Marc
51Einstein, Mark
52Teeter, Randall
53Benz, Stephen
54Wentzensen, Nicolas
55Felau, Ina
56Zenklusen, Jean C
57Bodelon, Clara
58Demchok, John A
59Yang, Liming
60Sheth, Margi
61Ferguson, Martin L
62Tarnuzzer, Roy
63Yang, Hannah
64Schiffman, Mark
65Zhang, Jiashan
66Wang, Zhining
67Davidsen, Tanja
68Olaniyan, Olayinka
69Hutter, Carolyn M
70Sofia, Heidi J
71Gordenin, Dmitry A
72Chan, Kin
73Roberts, Steven A
74Klimczak, Leszek J
75Van Waes, Carter
76Chen, Zhong
77Saleh, Anthony D
78Cheng, Hui
79Parfitt, Jeremy
80Bartlett, John
81Albert, Monique
82Arnaout, Angel
83Sekhon, Harman
84Gilbert, Sebastien
85Peto, Myron
86Myers, Jerome
87Harr, Jodi
88Eckman, John
89Bergsten, Julie
90Tucker, Kelinda
91Zach, Leigh Anne
92Karlan, Beth Y
93Lester, Jenny
94Orsulic, Sandra
95Sun, Qiang
96Naresh, Rashi
97Pihl, Todd
98Wan, Yunhu
99Zaren, Howard
100...
atitleIntegrated genomic and molecular characterization of cervical cancer.
jtitleNature
risdate20170316
volume543
issue7645
spage378
epage384
pages378-384
eissn1476-4687
formatjournal
genrearticle
ristypeJOUR
doi10.1038/nature21386
urlhttp://search.proquest.com/docview/1861597110/
issn00280836
date2017-03-16
Cannot write session to /tmp/vufind_sessions/sess_205hk6v2v6limocjjhksr9ufc6