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Dietary Tryptophan Enhanced the Expression of Tight Junction Protein ZO-1 in Intestine.

Dietary amino acids provide various beneficial effects for our health. The aim of the present study was to assess the effects of tryptophan (Trp) supplementation on barrier function. Ninety‐six healthy finishing pigs (initial body weight 51.49 ± 1.12 kg) were randomly allocated into 2 treatment grou... Full description

Journal Title: Journal of food science February 2017, Vol.82(2), pp.562-567
Main Author: Liu, Wenhui
Other Authors: Mi, Shumei , Ruan, Zheng , Li, Jing , Shu, Xugang , Yao, Kang , Jiang, Min , Deng, Zeyuan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1750-3841 ; DOI: 10.1111/1750-3841.13603
Link: http://search.proquest.com/docview/1866289445/?pq-origsite=primo
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recordid: proquest1866289445
title: Dietary Tryptophan Enhanced the Expression of Tight Junction Protein ZO-1 in Intestine.
format: Article
creator:
  • Liu, Wenhui
  • Mi, Shumei
  • Ruan, Zheng
  • Li, Jing
  • Shu, Xugang
  • Yao, Kang
  • Jiang, Min
  • Deng, Zeyuan
subjects:
  • Animal Feed–Metabolism
  • Animals–Chemistry
  • Body Weight–Metabolism
  • Claudin-3–Metabolism
  • Diet–Drug Effects
  • Dietary Supplements–Metabolism
  • Endotoxins–Chemistry
  • Intestinal Mucosa–Metabolism
  • Permeability–Metabolism
  • RNA, Messenger–Metabolism
  • Random Allocation–Metabolism
  • Signal Transduction–Metabolism
  • Swine–Metabolism
  • Tight Junctions–Metabolism
  • Tryptophan–Metabolism
  • Zonula Occludens-1 Protein–Metabolism
  • Claudin-3
  • Endotoxins
  • RNA, Messenger
  • Zonula Occludens-1 Protein
ispartof: Journal of food science, February 2017, Vol.82(2), pp.562-567
description: Dietary amino acids provide various beneficial effects for our health. The aim of the present study was to assess the effects of tryptophan (Trp) supplementation on barrier function. Ninety‐six healthy finishing pigs (initial body weight 51.49 ± 1.12 kg) were randomly allocated into 2 treatment groups, control group, and 0.2% Trp group. The control group was fed the basal diet, and 0.2% Trp group was fed basal diet plus 0.2% Trp. The trial period is 60 d. Compared with control group, the mRNA abundance of claudin‐3 and zonula occluden‐1 (ZO‐1) in the jejunum in 0.2% Trp group ( < 0.05) was increased. According to immunohistochemistry and immunoblotting test, the expression of ZO‐1 in jejunum in 0.2% Trp group was also significantly increased compared with the control group ( < 0.05). These results revealed that Trp enhanced the expression of tight junction protein ZO‐1 in the intestine of pig model. Trp may be potential and beneficial dietary functional factor for regulating the intestinal development and inhibiting intestinal aging. The work has beneficial for intestinal health, such as promoting the gut development and inhibiting intestinal aging for the aged. The research has direct commercial application for amino acids supplementation or prebiotics.
language: eng
source:
identifier: E-ISSN: 1750-3841 ; DOI: 10.1111/1750-3841.13603
fulltext: fulltext
issn:
  • 17503841
  • 1750-3841
url: Link


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titleDietary Tryptophan Enhanced the Expression of Tight Junction Protein ZO-1 in Intestine.
creatorLiu, Wenhui ; Mi, Shumei ; Ruan, Zheng ; Li, Jing ; Shu, Xugang ; Yao, Kang ; Jiang, Min ; Deng, Zeyuan
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ispartofJournal of food science, February 2017, Vol.82(2), pp.562-567
identifierE-ISSN: 1750-3841 ; DOI: 10.1111/1750-3841.13603
subjectAnimal Feed–Metabolism ; Animals–Chemistry ; Body Weight–Metabolism ; Claudin-3–Metabolism ; Diet–Drug Effects ; Dietary Supplements–Metabolism ; Endotoxins–Chemistry ; Intestinal Mucosa–Metabolism ; Permeability–Metabolism ; RNA, Messenger–Metabolism ; Random Allocation–Metabolism ; Signal Transduction–Metabolism ; Swine–Metabolism ; Tight Junctions–Metabolism ; Tryptophan–Metabolism ; Zonula Occludens-1 Protein–Metabolism ; Claudin-3 ; Endotoxins ; RNA, Messenger ; Zonula Occludens-1 Protein
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descriptionDietary amino acids provide various beneficial effects for our health. The aim of the present study was to assess the effects of tryptophan (Trp) supplementation on barrier function. Ninety‐six healthy finishing pigs (initial body weight 51.49 ± 1.12 kg) were randomly allocated into 2 treatment groups, control group, and 0.2% Trp group. The control group was fed the basal diet, and 0.2% Trp group was fed basal diet plus 0.2% Trp. The trial period is 60 d. Compared with control group, the mRNA abundance of claudin‐3 and zonula occluden‐1 (ZO‐1) in the jejunum in 0.2% Trp group ( < 0.05) was increased. According to immunohistochemistry and immunoblotting test, the expression of ZO‐1 in jejunum in 0.2% Trp group was also significantly increased compared with the control group ( < 0.05). These results revealed that Trp enhanced the expression of tight junction protein ZO‐1 in the intestine of pig model. Trp may be potential and beneficial dietary functional factor for regulating the intestinal development and inhibiting intestinal aging. The work has beneficial for intestinal health, such as promoting the gut development and inhibiting intestinal aging for the aged. The research has direct commercial application for amino acids supplementation or prebiotics.
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authorLiu, Wenhui ; Mi, Shumei ; Ruan, Zheng ; Li, Jing ; Shu, Xugang ; Yao, Kang ; Jiang, Min ; Deng, Zeyuan
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