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No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs.

To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s12402-017-0219-8 Byline: Julia M. Geissler (1), Marcel Romanos (1), Manfred Gerlach (1), Daniela Berg (2,3,4), Claudia Schulte (2,3) Keywords: ADHD; Parkinson's diseas... Full description

Journal Title: Attention deficit and hyperactivity disorders June 2017, Vol.9(2), pp.121-127
Main Author: Geissler, Julia M
Other Authors: Romanos, Marcel , Gerlach, Manfred , Berg, Daniela , Schulte, Claudia , Geissler, Julia M
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1866-6647 ; DOI: 10.1007/s12402-017-0219-8
Link: http://search.proquest.com/docview/1866294692/?pq-origsite=primo
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title: No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs.
format: Article
creator:
  • Geissler, Julia M
  • Romanos, Marcel
  • Gerlach, Manfred
  • Berg, Daniela
  • Schulte, Claudia
  • Geissler, Julia M
subjects:
  • Attention Deficit Disorder With Hyperactivity–Genetics
  • Genetic Association Studies–Genetics
  • Genetic Predisposition to Disease–Genetics
  • Humans–Genetics
  • Parkinson Disease–Genetics
  • Polymorphism, Single Nucleotide–Genetics
  • ADHD
  • Cdh13
  • Dopamine Transporter
  • Gwas
  • Parkinson’s Disease
  • Snps
ispartof: Attention deficit and hyperactivity disorders, June 2017, Vol.9(2), pp.121-127
description: To access, purchase, authenticate, or subscribe to the full-text of this article, please visit this link: http://dx.doi.org/10.1007/s12402-017-0219-8 Byline: Julia M. Geissler (1), Marcel Romanos (1), Manfred Gerlach (1), Daniela Berg (2,3,4), Claudia Schulte (2,3) Keywords: ADHD; Parkinson's disease; GWAS; SNPs; CDH13; Dopamine transporter Abstract: Attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease (PD) involve pathological changes in brain structures such as the basal ganglia, which are essential for the control of motor and cognitive behavior and impulsivity. The cause of ADHD and PD remains unknown, but there is increasing evidence that both seem to result from a complicated interplay of genetic and environmental factors affecting numerous cellular processes and brain regions. To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal-associated protein 25 k (SNAP25), the dopamine (DA) transporter (SLC6A3 DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13). Information was extracted from a recent meta-analysis of five genome-wide association studies, in which 7,689,524 SNPs in European samples were successfully imputed. No significant association was observed after correction for multiple testing. Therefore, it is reasonable to conclude that candidate variants implicated in the pathogenesis of ADHD do not play a substantial role in PD. Author Affiliation: (1) Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Center of Mental Health, University Hospital of Wurzburg, Margarete-Hoppel-Platz 1, 97080, Wurzburg, Germany (2) Department of Neurodegeneration, Hertie-Institute of Clinical Brain Research, University of Tubingen, Tubingen, Germany (3) DZNE--German Center for Neurodegenerative Diseases, University of Tubingen, Tubingen, Germany (4) Department of Neurology, Christian-Albrechts-University, Kiel, Germany Article History: Registration Date: 18/01/2017 Received Date: 01/04/2016 Accepted Date: 18/01/2017 Online Date: 07/02/2017
language: eng
source:
identifier: E-ISSN: 1866-6647 ; DOI: 10.1007/s12402-017-0219-8
fulltext: fulltext
issn:
  • 18666647
  • 1866-6647
url: Link


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titleNo genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs.
creatorGeissler, Julia M ; Romanos, Marcel ; Gerlach, Manfred ; Berg, Daniela ; Schulte, Claudia ; Geissler, Julia M
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ispartofAttention deficit and hyperactivity disorders, June 2017, Vol.9(2), pp.121-127
identifierE-ISSN: 1866-6647 ; DOI: 10.1007/s12402-017-0219-8
subjectAttention Deficit Disorder With Hyperactivity–Genetics ; Genetic Association Studies–Genetics ; Genetic Predisposition to Disease–Genetics ; Humans–Genetics ; Parkinson Disease–Genetics ; Polymorphism, Single Nucleotide–Genetics ; ADHD ; Cdh13 ; Dopamine Transporter ; Gwas ; Parkinson’s Disease ; Snps
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titleNo genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs.
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11Simón-Sánchez, Javier
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14Arepalli, Sampath
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18Bhatia, Kailash
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20Biffi, Alessandro
21Bloem, Bas
22Bochdanovits, Zoltan
23Bonin, Michael
24Bras, Jose M
25Brockmann, Kathrin
26Brooks, Janet
27Burn, David J
28Charlesworth, Gavin
29Chen, Honglei
30Chinnery, Patrick F
31Chong, Sean
32Clarke, Carl E
33Cookson, Mark R
34Cooper, J Mark
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36Counsell, Carl
37Damier, Philippe
38Dartigues, Jean-François
39Deloukas, Panos
40Deuschl, Günther
41Dexter, David T
42van Dijk, Karin D
43Dillman, Allissa
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45Dürr, Alexandra
46Edkins, Sarah
47Evans, Jonathan R
48Foltynie, Thomas
49Gao, Jianjun
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51Gibbs, J Raphael
52Goate, Alison
53Gray, Emma
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55Gústafsson, Ómar
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57van Hilten, Jacobus J
58Hofman, Albert
59Hollenbeck, Albert
60Holton, Janice
61Hu, Michele
62Huang, Xuemei
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70Limousin, Patricia
71Lopez, Grisel
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79O'Sullivan, Sean S
80Pearson, Justin
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83Pollak, Pierre
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atitleNo genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs.
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